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Sökning: onr:"swepub:oai:lup.lub.lu.se:d9c3dc21-75af-4a6c-b7c7-53bc492d03dc" > The Parkinson's Dis...

The Parkinson's Disease Genome-Wide Association Study Locus Browser

Grenn, Francis P. (författare)
National Institutes of Health, United States
Kim, Jonggeol J. (författare)
National Institutes of Health, United States
Makarious, Mary B. (författare)
National Institutes of Health, United States
visa fler...
Iwaki, Hirotaka (författare)
National Institutes of Health, United States,Data Tecnica International
Illarionova, Anastasia (författare)
German Center for Neurodegenerative Diseases (DZNE), Bonn
Brolin, Kajsa (författare)
Lund University,Lunds universitet,Translationell Neurogenetik,Forskargrupper vid Lunds universitet,Translational Neurogenetics,Lund University Research Groups
Kluss, Jillian H. (författare)
National Institutes of Health, United States
Schumacher-Schuh, Artur F. (författare)
Hospital de Clinicas de Porto Alegre
Leonard, Hampton (författare)
Data Tecnica International,National Institutes of Health, United States
Faghri, Faraz (författare)
Data Tecnica International,National Institutes of Health, United States
Billingsley, Kimberley (författare)
National Institutes of Health, United States
Krohn, Lynne (författare)
McGill University
Hall, Ashley (författare)
University of Liverpool
Diez-Fairen, Monica (författare)
Mutua De Terrassa Hospital
Periñán, Maria Teresa (författare)
University Hospital Virgen del Rocío
Sandor, Cynthia (författare)
Cardiff University
Webber, Caleb (författare)
Cardiff University
Fiske, Brian K. (författare)
The Michael J. Fox Foundation for Parkinson’s Research
Gibbs, J. Raphael (författare)
National Institutes of Health, United States
Nalls, Mike A. (författare)
Data Tecnica International,National Institutes of Health, United States
Singleton, Andrew B. (författare)
National Institutes of Health, United States
Bandres-Ciga, Sara (författare)
National Institutes of Health, United States
Reed, Xylena (författare)
National Institutes of Health, United States
Blauwendraat, Cornelis (författare)
National Institutes of Health, United States
visa färre...
 (creator_code:org_t)
John Wiley and Sons, 2020
2020
Engelska.
Ingår i: Movement Disorders. - : John Wiley and Sons. - 0885-3185.
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Parkinson's disease (PD) is a neurodegenerative disease with an often complex component identifiable by genome-wide association studies. The most recent large-scale PD genome-wide association studies have identified more than 90 independent risk variants for PD risk and progression across more than 80 genomic regions. One major challenge in current genomics is the identification of the causal gene(s) and variant(s) at each genome-wide association study locus. The objective of the current study was to create a tool that would display data for relevant PD risk loci and provide guidance with the prioritization of causal genes and potential mechanisms at each locus. Methods: We included all significant genome-wide signals from multiple recent PD genome-wide association studies including themost recent PD risk genome-wide association study, age-at-onset genome-wide association study, progression genome-wide association study, and Asian population PD risk genome-wide association study. We gathered data for all genes 1 Mb up and downstream of each variant to allow users to assess which gene(s) are most associated with the variant of interest based on a set of self-ranked criteria. Multiple databases were queried for each gene to collect additional causal data. Results: We created a PD genome-wide association study browser tool (https://pdgenetics.shinyapps.io/GWASBrowser/) to assist the PD research community with the prioritization of genes for follow-up functional studies to identify potential therapeutic targets. Conclusions: Our PD genome-wide association study browser tool provides users with a useful method of identifying potential causal genes at all known PD risk loci from large-scale PD genome-wide association studies. We plan to update this tool with new relevant data as sample sizes increase and new PD risk loci are discovered.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

Nyckelord

GWAS
Parkinson's disease
prioritization

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ref (ämneskategori)
art (ämneskategori)

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