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Sökning: onr:"swepub:oai:lup.lub.lu.se:eaf36acf-e433-4c17-a1f2-eb6e669d292c" > National Incidence ...

  • Onnestam, LisaUniversity of Gothenburg, Sweden (författare)

National Incidence and Prevalence of TSH-Secreting Pituitary Adenomas in Sweden.

  • Artikel/kapitelEngelska2013

Förlag, utgivningsår, omfång ...

  • Oxford University Press,2013

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:eaf36acf-e433-4c17-a1f2-eb6e669d292c
  • https://lup.lub.lu.se/record/3438959URI
  • https://doi.org/10.1210/jc.2012-3362DOI
  • https://gup.ub.gu.se/publication/171358URI
  • urn:nbn:se:liu:diva-91021urn
  • urn:nbn:se:umu:diva-66843urn
  • urn:nbn:se:uu:diva-198424urn
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:126376720URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Sahlgrens Academy at Gothenburg University||Swedish Society for Medical Research, Sweden||LUA/Alf agreement of Sahlgrenska University Hospital, Gothenburg||Swedish Pituitary Registry||
  • gratis
  • Context:TSH-secreting pituitary adenomas (TSHomas) are rare. Epidemiological data are scant and there are no reports on national incidence.Objective:The objective of the study was to estimate the national Swedish incidence and prevalence of TSHomas.Design:This was an observational study.Setting:The study was conducted at tertiary referral centers.Patients:The Swedish Pituitary Registry and World Health Organization International Statistical Classification of Diseases and Related Health Problems coding at all university hospitals were used to identify patients diagnosed with TSHomas 1990-2010. The identified patients' medical records were studied until the latest follow-up [median 5.0 years (range < 1-20 years)].Main Outcome Measurements:Incidence, prevalence, demographics, tumor characteristics, treatment outcome, and thyroid hormone level at diagnosis were measured.Results:The age-standardized national incidence of 28 TSHoma patients was 0.15 per 1 million inhabitants per year, with an increasing incidence over time (0.05 per 1 million per year in 1990-1994 to 0.26 per 1 million per year in 2005-2009). The national prevalence in 2010 was 2.8 per 1 million inhabitants, in which 0.85 per 1 million had active disease. Most patients (n = 22) underwent pituitary surgery, 5 had radiotherapy, and 6 had somatostatin analogues. Eighteen patients were considered cured at the latest follow-up; 25% remained uncontrolled. Subjects treated for putative primary hyperthyroidism prior to diagnosis had TSH levels more than double those with intact thyroid at diagnosis (P = .013). The median time to diagnosis was longer for women than men (4 vs < 1 year, P = .026). More women than men were treated surgically (94.1% vs 54.5%, P = .022).Conclusion:This is the first estimate of a national incidence of TSHoma. Additional epidemiological studies are needed to compare these results with other geographical areas. This study suggests an increased incidence of TSHomas, in agreement with reports on other pituitary adenomas.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Berinder, KatarinaKarolinska University Hospital Solna, Sweden (författare)
  • Burman, PiaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital, Sweden(Swepub:lu)med-bap (författare)
  • Dahlqvist, PerUmeå universitet,Medicin (författare)
  • Engström, Britt EdénUppsala universitet,Endokrin diabetes och metabolism (författare)
  • Wahlberg, Jeanette (författare)
  • Nyström, Helena FilipssonGothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine (författare)
  • Önnestam, LisaGothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)192801 (författare)
  • Filipsson Nystrom, HelenaUniversity of Gothenburg, Sweden (författare)
  • Wahlberg Topp, JeanetteÖstergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Endokrinmedicinska kliniken(Swepub:liu)jeawa98 (författare)
  • Eden Engstrom, BrittUniversity of Uppsala Hospital, Sweden (författare)
  • Nystrom, Helena Filipsson (författare)
  • Berinder, KKarolinska Institutet(Swepub:ki)104b2708541c92c5e0161f433f168e4d (författare)
  • Nystrom, HF (författare)
  • Burman, P (författare)
  • Wahlberg, J (författare)
  • Dahlqvist, P (författare)
  • Engstrom, BE (författare)
  • Onnestam, L (författare)
  • University of Gothenburg, SwedenKarolinska University Hospital Solna, Sweden (creator_code:org_t)
  • Gothenburg University
  • Göteborgs universitet

Sammanhörande titlar

  • Ingår i:Journal of Clinical Endocrinology and Metabolism: Oxford University Press98:2, s. 626-6351945-71970021-972X

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