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Sökning: onr:"swepub:oai:lup.lub.lu.se:ffe21406-c27e-42dc-9810-fa6aa7c64d15" > Outcome of patients...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003756naa a2200577 4500
001oai:lup.lub.lu.se:ffe21406-c27e-42dc-9810-fa6aa7c64d15
003SwePub
008160401s2010 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:120141445
0247 a https://lup.lub.lu.se/record/15891532 URI
0247 a https://doi.org/10.1038/bmt.2009.1772 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1201414452 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Chalandon, Y.4 aut
2451 0a Outcome of patients developing GVHD after DLI given to treat CML relapse: a study by the chronic leukemia working party of the EBMT
264 c 2009-07-27
264 1b Springer Science and Business Media LLC,c 2010
520 a We studied GVHD after donor lymphocyte infusion (DLI) in 328 patients with relapsed CML between 1991 and 2004. A total of 122 patients (38%) developed some form of GVHD. We analyzed GVHD by clinical presentation (acute or chronic GVHD) and onset time after the first DLI (early (<= 45 days) or late (>45 days)). There was a significant overlap between onset time and clinical presentation. Some form of GVHD occurred at a median of 104 days, acute GVHD at 45 days and chronic GVHD at 181 days after DLI. The clinical presentation was acute GVHD in 71 patients, of whom 31 subsequently developed chronic GVHD subsequently. De novo chronic GVHD was seen in 51 patients. OS for all patients was 69% (95% confidence interval (CI) 63-75) at 5 years, DLI-related mortality was 11% (95% CI 8-15) and disease-related mortality was 20% (95% CI 16-25). Risk factors for developing GVHD after DLI were T-cell dose at first DLI, the time interval from transplant to DLI and donor type. In time-dependent multivariate analysis, GVHD after DLI was associated with a risk of death of 2.3-fold compared with patients without GVHD. Clinical presentation as acute GVHD and early onset GVHD were associated with increased mortality.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
653 a allo-SCT
653 a GVHD
653 a CML
653 a DLI
653 a relapse
7001 a Passweg, J. R.4 aut
7001 a Schmid, C.4 aut
7001 a Olavarria, E.4 aut
7001 a Dazzi, F.4 aut
7001 a Simula, M. P.4 aut
7001 a Ljungman, P.u Karolinska Institutet4 aut
7001 a Schattenberg, A.4 aut
7001 a de Witte, T.4 aut
7001 a Lenhoff, Stigu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-slf
7001 a Jacobs, P.4 aut
7001 a Volin, L.4 aut
7001 a Iacobelli, S.4 aut
7001 a Finke, J.4 aut
7001 a Niederwieser, D.4 aut
7001 a Guglielmi, C.4 aut
7102 a Karolinska Institutetb Avdelningen för hematologi och transfusionsmedicin4 org
7730 t Bone Marrow Transplantationd : Springer Science and Business Media LLCg 45:3, s. 558-564q 45:3<558-564x 1476-5365x 0268-3369
8564 u http://dx.doi.org/10.1038/bmt.2009.177y FULLTEXT
8564 u https://www.nature.com/articles/bmt2009177.pdf
8564 8u https://lup.lub.lu.se/record/1589153
8564 8u https://doi.org/10.1038/bmt.2009.177
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:120141445

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