onr:"swepub:oai:portal.research.lu.se:publications/364311c0-c0ee-4e4f-88ea-0b002dc47d56"
Sökning: onr:"swepub:oai:portal.research.lu.se:publications/364311c0-c0ee-4e4f-88ea-0b002dc47d56" > Investigating Ras h...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Kristiansson, AmandaNeonatology,Neonatologi,Skåne University Hospital (författare)
Investigating Ras homolog gene family member C (RhoC) and Ki67 expression following external beam radiation therapy show increased RhoC expression in relapsing prostate cancer xenografts
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
- Elsevier,2024
Nummerbeteckningar
- LIBRIS-ID:oai:portal.research.lu.se:publications/364311c0-c0ee-4e4f-88ea-0b002dc47d56
- oai:portal.research.lu.se:publications/364311c0-c0ee-4e4f-88ea-0b002dc47d56URI
- https://doi.org/10.1016/j.bbrc.2024.150324DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Ras homolog gene family member C (RhoC) is a GTPase involved in cell migration, implicated in epithelial-mesenchymal transition and treatment resistance and metastasis of cancer. For example, RhoC has been shown to be involved in resistance to radiation in cervical carcinoma. Here, the effect of X-ray irradiation on RhoC expression in prostate cancer (PCa) xenografts was investigated in both xenografts in regression and relapse. Male BALB/cAnNRj-Foxn1nu/nu mice were inoculated with 4–6 million LNCaP-FGC cells and established xenografts were irradiated with X-rays (200 kV, 1 Gymin-1), 5, 10 or 15 Gy using a Gulmay Medical X-ray system. Expression of RhoC and Ki67, a known proliferation marker, was investigated in xenografts, given 15 Gy, 7 days (midst response as measured by size) or 3 weeks (relapse) post irradiation. Staining was quantified using the Halo software (v2.3.2089.34) with the Indica Labs – cytonuclear v1.6 algorithm. RhoC and Ki67 staining was divided into weak, medium, and strong staining and the percentage of cells stained, single and dual staining, was quantified. The HALO software was further used to classify the tissue in each section so that analysis of RhoC and Ki67 expression in cancer cells, stroma and necrotic areas could be done separately. The results showed that RhoC expression in cancer and stroma cells was significantly higher in relapsed xenografts than in those in regression. This was not seen for Ki67 staining, where the percentage of stained cells were the same in regressing and relapsing tumors. RhoC could be a useful biomarker to confirm relapse following external beam radiation therapy.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Ceberg, CristerMedical Radiation Physics, Lund,Radiotherapy Physics,LU Profile Area: Light and Materials,Medicinsk strålningsfysik, Lund,LU profilområde: Ljus och material(Swepub:lu)6a27555e-50fa-49d7-b5a1-47d4bd21dda2 (författare)
- Bjartell, AndersUrological cancer, Malmö,eSSENCE: The e-Science Collaboration,EpiHealth: Epidemiology for Health,LUCC: Lund University Cancer Centre,Division of Translational Cancer Research,Urologisk cancerforskning, Malmö,LUCC: Lunds universitets cancercentrum,Avdelningen för translationell cancerforskning(Swepub:lu)962bdf27-ab40-43e9-bf03-0e7a9b20080f (författare)
- Ceder, JensSystemic Radiation Therapy Group,Radiation therapy,LUCC: Lund University Cancer Centre,Forskningsgruppen för Systemisk strålterapi,Strålterapi,LUCC: Lunds universitets cancercentrum(Swepub:lu)2f839662-2b0b-4c86-9132-deb0347d0e59 (författare)
- Timmermand, Oskar VilhelmssonSystemic Radiation Therapy Group,LUCC: Lund University Cancer Centre,Radiation therapy,Forskningsgruppen för Systemisk strålterapi,LUCC: Lunds universitets cancercentrum,Strålterapi(Swepub:lu)0faa3c6b-6da6-41f5-a51b-70ccccddd1f6 (författare)
- NeonatologyNeonatologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Biochemical and Biophysical Research Communications: Elsevier7280006-291X
Internetlänk
- https://doi.org/10.1016/j.bbrc.2024.150324FULLTEXT
- oai:portal.research.lu.se:publications/364311c0-c0ee-4e4f-88ea-0b002dc47d56
- https://doi.org/10.1016/j.bbrc.2024.150324
Hitta via bibliotek
- Biochemical and Biophysical Research Communications (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Kristiansson, Am ...
- Ceberg, Crister
- Bjartell, Anders
- Ceder, Jens
- Timmermand, Oska ...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Cancer och onkol ...
- Artiklar i publikationen
- Biochemical and ...
- Av lärosätet
- Lunds universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst. Hantera kakor
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
