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Sökning: onr:"swepub:oai:research.chalmers.se:c519a19c-00f7-49a6-83ed-d36127ea1fb5" > The effect of alend...

  • Karlsson, Johan,1984Chalmers University of Technology,Chalmers tekniska högskola,Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden. (författare)

The effect of alendronate on biomineralization at the bone/implant interface

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016

Nummerbeteckningar

  • LIBRIS-ID:oai:research.chalmers.se:c519a19c-00f7-49a6-83ed-d36127ea1fb5
  • https://research.chalmers.se/publication/230078URI
  • https://doi.org/10.1002/jbm.a.35602DOI
  • urn:nbn:se:uu:diva-277970urn

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • A recent approach to improve osseointegration of implants is to utilize local drug administration. The presence of an osteoporosis drug may influence both bone quantity and quality at the bone/implant interface. Despite this, the performance of bone-anchoring implants is traditionally evaluated only by quantitative measurements. In the present study, the osteoporosis drug alendronate (ALN) was administrated from mesoporous titania thin films that were coated onto titanium implants. The effect that the drug had on biomineralization was explored both in vitro using simulated body fluid (SBF) and in vivo in a rat tibia model. The SBF study showed that the apatite formation was completely hindered at a high concentration of ALN (0.1 mg/ml). However, when ALN was administrated from the mesoporous coating the surface became completely covered with apatite. Ex vivo characterization of the bone/implant interface using Raman spectroscopy demonstrated that the presence of ALN enhanced the bone mineralization, and that the chemical signature of newly formed bone in the presence of ALN had a higher resemblance to the pre-existing mature bone than to the bone formed without drug. Taken together, this study demonstrates the importance of evaluating the quality of the formed bone to better understand the performance of implants.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Martinelli, Anna,1978Chalmers University of Technology,Chalmers tekniska högskola,Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.(Swepub:cth)annamart (författare)
  • Mashadi Fathali, Hoda,1983Chalmers University of Technology,Chalmers tekniska högskola(Swepub:cth)mashadi (författare)
  • Bielecki, Johan,1982Uppsala University,Uppsala universitet,Molekylär biofysik(Swepub:cth)bieljoha (författare)
  • Andersson, Martin,1974Chalmers University of Technology,Chalmers tekniska högskola,Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.(Swepub:cth)martina (författare)
  • Fathali, Hoda M.Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden. (författare)
  • Chalmers University of TechnologyChalmers tekniska högskola (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Biomedical Materials Research - Part A104:3, s. 620-6291549-32961552-4965

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