The immune response against hapten-autologous protein conjugates in the mouse. II. Carrier specificity in the secondary anti-hapten response and evidence of the existence of specific helper cells.

• The carrier specificity of secondary anti‐hapten responses using different haptenic densities on autologous or heterologous carrier proteins was studied. In addition, the T cell requirements for anti‐hapten antibody synthesis were investigated. The results demonstrated a clearcut decrease in carrier specificity as hapten density goes up. Also, memory against autologous hapten carrier conjugates at the T cell level waned with time in contrast to the memory against heterologous hapten‐carrier conjugates. Specific helper cells against autologous conjugates were demonstrated by filtration through anti‐immunoglobulin coated columns.

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