Autophagic cell death / Eric H. Baehrecke.

• Contents: Morphological forms of cell death -- Why is autophagy of interest to cell death researchers? -- What is autophagy? -- Discovery of autophagy genes -- How is autophagy regulated? -- Class I PI3K signalling and Class III PI3K signalling -- Ubiquitin-like conjugation systems -- Where has autophagic cell death been observed? -- What are the possible roles of autophagy in dying cells? -- Evidence in support of autophagy prolonging cell survival -- Studies in flies and mammals suggest that both autophagy and caspases can be involved in cell death of the same cell -- Evidence in support of autophagy promoting cell death -- Inhibition of caspase-8 promotes autophagic cell death of L929 cells by autophagic degradation of catalase.

Ämnesord

Apoptosis.  (MeSH)

Autophagy.  (MeSH)