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Global analysis of ...
Global analysis of A-to-I RNA editing reveals association with common disease variants
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Franzen, Oscar (författare)
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Ermel, Raili (författare)
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Sukhavasi, Katyayani (författare)
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visa fler...
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Jain, Rajeev (författare)
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Jain, Anamika (författare)
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Betsholtz, Christer (författare)
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Giannarelli, Chiara (författare)
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Kovacic, Jason C. (författare)
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Ruusalepp, Arno (författare)
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Skogsberg, Josefin (författare)
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Hao, Ke (författare)
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Schadt, Eric E. (författare)
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Bjoerkegren, Johan L. M. (författare)
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(utgivare)
- 2018
- 2018
- Engelska.
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Ingår i: PeerJ. - 2167-8359. ; 6
Abstract
Ämnesord
Stäng
- RNA editing modifies transcripts and may alter their regulation or function. In humans, the most common modification is adenosine to inosine (A-to-I). We examined the global characteristics of RNA editing in 4,301 human tissue samples. More than 1.6 million A-to-I edits were identified in 62% of all protein-coding transcripts. mRNA recoding was extremely rare; only 11 novel recoding sites were uncovered. Thirty single nucleotide polymorphisms from genome-wide association studies were associated with RNA editing; one that influences type 2 diabetes (rs2028299) was associated with editing in ARPIN. Twenty-five genes, including LRP11 and PLIN5, had editing sites that were associated with plasma lipid levels. Our findings provide new insights into the genetic regulation of RNA editing and establish a rich catalogue for further exploration of this process.
Ämnesord
- Medical and Health Sciences (hsv)
- Basic Medicine (hsv)
- Cell and Molecular Biology (hsv)
- Medicin och hälsovetenskap (hsv)
- Medicinska och farmaceutiska grundvetenskaper (hsv)
- Cell- och molekylärbiologi (hsv)
Nyckelord
- RNA editing
- Gene expression
- Quantitative trait loci
- RNA-seq
- Bioinformatics
- Biostatistics
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Franzen, Oscar
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Ermel, Raili
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Sukhavasi, Katya ...
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Jain, Rajeev
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Jain, Anamika
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Betsholtz, Chris ...
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visa fler...
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Giannarelli, Chi ...
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Kovacic, Jason C ...
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Ruusalepp, Arno
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Skogsberg, Josef ...
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Hao, Ke
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Schadt, Eric E.
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Bjoerkegren, Joh ...
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visa färre...
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