Sökning: WFRF:(Rohrmann Sabine)
> (2014) >
Obesity and cancer
Obesity and cancer the role of vitamin D
-
Shanmugalingam, Thurkaa (författare)
-
Crawley, Danielle (författare)
-
Bosco, Cecilia (författare)
-
visa fler...
-
Melvin, Jennifer (författare)
-
Rohrmann, Sabine (författare)
-
Chowdhury, Simon (författare)
-
Holmberg, Lars (författare)
-
Van Hemelrijck, Mieke (författare)
-
visa färre...
-
(utgivare)
- 2014
- 2014
- Engelska.
-
Ingår i: BMC Cancer. - 1471-2407. ; 14, 712
Abstract
Ämnesord
Stäng
- Background: It is estimated that 20% of all cancer cases are caused by obesity. Vitamin D is thought to be one of the mechanisms underlying this association. This review aims to summarise the evidence for the mediating effect of vitamin D on the link between obesity and cancer. Methods: Three literature searches using PubMed and Embase were conducted to assess whether vitamin D plays an important role in the pathway between obesity and cancer: (1) obesity and cancer; (2) obesity and vitamin D; and (3) vitamin D and cancer. A systematic review was performed for (1) and (3), whereas a meta-analysis including random effects analyses was performed for (2). Results: (1) 32 meta-analyses on obesity and cancer were identified; the majority reported a positive association between obesity and risk of cancer. (2) Our meta-analysis included 12 original studies showing a pooled relative risk of 1.52 (95% CI: 1.33-1.73) for risk of vitamin D deficiency (<50 nmol/L) in obese people (body mass index >30 kg/m(2)). (3) 21 meta-analyses on circulating vitamin D levels and cancer risk were identified with different results for different types of cancer. Conclusion: There is consistent evidence for a link between obesity and cancer as well as obesity and low vitamin D. However, it seems like the significance of the mediating role of vitamin D in the biological pathways linking obesity and cancer is low. There is a need for a study including all three components while dealing with bias related to dietary supplements and vitamin D receptor polymorphisms.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Cancer and Oncology (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Cancer och onkologi (hsv)
Nyckelord
- Cancer
- Obesity
- Vitamin D
Hitta via bibliotek
Till lärosätets databas