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Genome and physiolo...
Genome and physiology of the ascomycete filamentous fungus Xeromyces bisporus, the most xerophilic organism isolated to date
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Leong, Su-lin L. (författare)
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Lantz, Henrik (författare)
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Pettersson, Olga Vinnere (författare)
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Frisvad, Jens C. (författare)
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Thrane, Ulf (författare)
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Heipieper, Hermann J. (författare)
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Dijksterhuis, Jan (författare)
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Grabherr, Manfred (författare)
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Pettersson, Mats (författare)
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Tellgren-Roth, Christian (författare)
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Schnurer, Johan (författare)
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- 2015
- 2015
- Engelska.
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Ingår i: Environmental Microbiology. - 1462-2912. ; 17:2, 496-513
Abstract
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- Xeromyces bisporus can grow on sugary substrates down to 0.61, an extremely low water activity. Its genome size is approximately 22Mb. Gene clusters encoding for secondary metabolites were conspicuously absent; secondary metabolites were not detected experimentally. Thus, in its dry' but nutrient-rich environment, X.bisporus appears to have relinquished abilities for combative interactions. Elements to sense/signal osmotic stress, e.g. HogA pathway, were present in X.bisporus. However, transcriptomes at optimal (approximate to 0.89) versus low a(w) (0.68) revealed differential expression of only a few stress-related genes; among these, certain (not all) steps for glycerol synthesis were upregulated. Xeromyces bisporus increased glycerol production during hypo- and hyper-osmotic stress, and much of its wet weight comprised water and rinsable solutes; leaked solutes may form a protective slime. Xeromyces bisporus and other food-borne moulds increased membrane fatty acid saturation as water activity decreased. Such modifications did not appear to be transcriptionally regulated in X.bisporus; however, genes modulating sterols, phospholipids and the cell wall were differentially expressed. Xeromyces bisporus was previously proposed to be a chaophile', preferring solutes that disorder biomolecular structures. Both X.bisporus and the closely related xerophile, Xerochrysium xerophilum, with low membrane unsaturation indices, could represent a phylogenetic cluster of chaophiles'.
Ämnesord
- Medical and Health Sciences (hsv)
- Basic Medicine (hsv)
- Microbiology in the medical area (hsv)
- Medicin och hälsovetenskap (hsv)
- Medicinska grundvetenskaper (hsv)
- Mikrobiologi inom det medicinska området (hsv)
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Leong, Su-lin L.
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Lantz, Henrik
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Pettersson, Olga ...
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Frisvad, Jens C.
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Thrane, Ulf
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Heipieper, Herma ...
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visa fler...
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Dijksterhuis, Ja ...
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Grabherr, Manfre ...
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Pettersson, Mats
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Tellgren-Roth, C ...
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Schnurer, Johan
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