| 1. |
- Chen, Han, 1986-
(författare)
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Characterization and Optimization of Silicon-strip Detectors for Mammography and Computed Tomography
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The goal in medical x-ray imaging is to obtain the image quality requiredfor a given detection task, while ensuring that the patient dose is kept as lowas reasonably achievable. The two most common strategies for dose reductionare: optimizing incident x-ray beams and utilizing energy informationof transmitted beams with new detector techniques (spectral imaging). Inthis thesis, dose optimization schemes were investigated in two x-ray imagingsystems: digital mammography and computed tomography (CT).In digital mammography, the usefulness of anti-scatter grids was investigatedas a function of breast thickness with varying geometries and experimentalconditions. The general conclusion is that keeping the grid is optimalfor breasts thicker than 5 cm, whereas the dose can be reduced without a gridfor thinner breasts.A photon-counting silicon-strip detector developed for spectral mammographywas characterized using synchrotron radiation. Energy resolution, ΔE/Ein, was measured to vary between 0.11-0.23 in the energy range 15-40 keV, which is better than the energy resolution of 0.12-0.35 measured inthe state-of-the-art photon-counting mammography system. Pulse pileup hasshown little effect on energy resolution.In CT, the performance of a segmented silicon-strip detector developedfor spectral CT was evaluated and a theoretical comparison was made withthe state-of-the-art CT detector for some clinically relevant imaging tasks.The results indicate that the proposed photon-counting silicon CT detector issuperior to the state-of-the-art CT detector, especially for high-contrast andhigh-resolution imaging tasks.The beam quality was optimized for the proposed photon-counting spectralCT detector in two head imaging cases: non-enhanced imaging and Kedgeimaging. For non-enhanced imaging, a 120-kVp spectrum filtered by 2half value layer (HVL) copper (Z = 29) provides the best performance. Wheniodine is used in K-edge imaging, the optimal filter is 2 HVL iodine (Z = 53)and the optimal kVps are 60-75 kVp. In the case of gadolinium imaging, theradiation dose can be minimized at 120 kVp filtered by 2 HVL thulium (Z =69).
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| 2. |
- Adamsson, Carl, 1976-
(författare)
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Dryout and Power Distribution Effects in Boiling Water Reactors
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Film flow measurements at several axial positions in round pipes with variousaxial power distributions are presented for conditions corresponding to normaloperation of a BWR. It is confirmed that the film flow rate approaches zero atthe onset of dryout. Selected phenomenological models of annular two-phaseflow are shown to reasonably reproduce the measurements. It is concluded thatmodels are in better agreement with measurements if terms corresponding topossible boiling induced entrainment are excluded. A method to perform film flow analysis in subchannels as a post-processto a standard two-field subchannel code is suggested. It is shown that thisapproach may yield accurate prediction of dryout power in rod bundles to alow computational cost and that the influence of the power distribution is wellpredicted by the model.
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| 4. |
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| 5. |
- Akpe, Victor
(författare)
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Photophysical and Chemical Approaches to Cellular Biophysics
- 2008
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The central theme in this thesis is reversibility. Two main attempts has been made to approach reversibility in cellular systems from both chemical and physical points of view. Reversibility of immunolabeling of proteins on the cell surface has been adressed by development of new fluorescent substances optimized for CALI (Chromophore-Assisted Laser Inactivation of protein). Aluminum phthalocyanine (AlPc) is here identified to be a good candidate for a new generation of fluorophores for efficient hydroxyl radical generation. It is shown that cells can be reversibly labeled with antibody-AlPc conjugates. In experiments on living cells the AlPcs were not only active as classic fluorophores but also as photocatalytic substances with destaining properties. Reversibility of cell immobilization is also reported, where cells cultured in microstructures were immobilized and 3D supported using hydrogels. Hydrogel formulation and application was optimized to achieve a system where both viability and ease of use was satisfied. Gel reversibility was actualized with pH and enzyme treatment. The developped method offers the possibility of stop flow culturing cells in controlled and reusable 3D environments.
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| 6. |
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| 7. |
- Almlöf, Jonas
(författare)
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Quantum error correction
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Quantum error correction is the art of protecting quantum states from the detrimental influence from the environment. To master this art, one must understand how the system interacts with the environment and gives rise to a full set of quantum phenomena, many of which have no correspondence in classical information theory. Such phenomena include decoherence, an effect that in general destroys superpositions of pure states as a consequence of entanglement with the environment. But decoherence can also be understood as “information leakage”, i.e., when knowledge of an encoded code block is transferred to the environment. In this event, the block’s information or entanglement content is typically lost.In a typical scenario, however, not all types of destructive events are likely to occur, but only those allowed by the information carrier, the type of interaction with the environment, and how the environment “picks up” information of the error events. These characteristics can be incorporated into a code, i.e., a channel-adapted quantum error-correcting code.Often, it is assumed that the environment’s ability to distinguish between error events is small, and I will denote such environments “memory-less”. But this assumption is not always valid, since the ability to distinguish error events is related to the temperature of the environment, and in the particular case of information coded onto photons, kBTR «ℏω typically holds, and one must then assume that the environment has a “memory”. In the thesis I describe a short quantum error-correction code adapted for photons interacting with a “cold” reservoir, i.e., a reservoir which continuously probes what error occurred in the coded state.I also study other types of environments, and show how to distill meaningful figures of merit from codes adapted for these channels, as it turns out that resource-based figures reflecting both information and entanglement can be calculated exactly for a well-studied class of channels: the Pauli channels. Starting from these resource-based figures, I establish the notion of efficiency and quality and show that there will be a trade-off between efficiency and quality for short codes. Finally I show how to incorporate, into these calculations, the choices one has to make when handling quantum states that have been detected as incorrect, but where no prospect of correcting them exists, i.e., so-called detection errors.
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| 8. |
- Almlöf, Jonas, 1973-
(författare)
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Quantum error correction
- 2012
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis intends to familiarise the reader with quantum error correction, and also show some relations to the well known concept of information - and the lesser known quantum information. Quantum information describes how information can be carried by quantum states, and how interaction with other systems give rise to a full set of quantum phenomena, many of which have no correspondence in classical information theory. These phenomena include decoherence, as a consequence of entanglement. Decoherence can also be understood as "information leakage", i.e., knowledge of an event is transferred to the reservoir - an effect that in general destroys superpositions of pure states.It is possible to protect quantum states (e.g., qubits) from interaction with the environment - but not by amplification or duplication, due to the "no-cloning" theorem. Instead, this is done using coding, non-demolition measurements, and recovery operations. In a typical scenario, however, not all types of destructive events are likely to occur, but only those allowed by the information carrier, the type of interaction with the environment, and how the environment "picks up" information of the error events. These characteristics can be incorporated into a code, i.e., a channel-adapted quantum error-correcting code. Often, it is assumed that the environment's ability to distinguish between error events is small, and I will denote such environments "memory-less". This assumption is not always valid, since the ability to distinguish error events is related to the \emph{temperature} of the environment, and in the particular case of information coded onto photons, typically holds, and one must then assume that the environment has a "memory". In this thesis, I describe a short quantum error-correcting code (QECC), adapted for photons interacting with a cold environment, i.e., this code protects from an environment that continuously records which error occurred in the coded quantum state.Also, it is of interest to compare the performance of different QECCs - But which yardstick should one use? We compare two such figures of merit, namely the quantum mutual information and the quantum fidelity, and show that they can not, in general, be simultaneously maximised in an error correcting procedure. To show this, we have used a five-qubit perfect code, but assumed a channel that only cause bit-flip errors. It appears that quantum mutual information is the better suited yardstick of the two, however more tedious to calculate than quantum fidelity - which is more commonly used.
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| 9. |
- Álvarez Ruiz, Jesús
(författare)
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Photon induced fluorescence studies of molecules using synchrotron radiation
- 2003
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This Licentiate thesis presents research accomplished at theSection of Atomic and Molecular Physics at the Royal Instituteof Technology in Stockholm using photon induced fluorescencespectroscopy (PIFS) during the last two years.The main results presented are summarized:- Neutral photodissociation in CO was observed aftersynchrotron photon excitation in the range 19-26 eV bycollecting dispersed fluorescence from excited neutral C atoms.Follow-up ab initio calculations point out CO Rydberg seriesconverging to the CO+ C and D states as precursors.- The branching ratio between N2 + (B-X)(v’=1,v’’=2) and (v’=0,v’’=1)transitions in the 20-46 eV energy range reveals strongnon-Franck-Condon effects. Ab initio calculations indicate thatthe autoionization of certain superexcited states areresponsible for some of the structures present in the branchingratio curve, confirming the important role of non-Rydbergdoubly excited resonant states (NRDERS) in de-excitationprocesses above the ionization potential.- Photon induced neutral dissociation processes in NO arereported. Neither Rydberg series nor other molecular states inNO known so far can account for the collected data. From abinitio calculations more information regarding the NO precursorstates and the mechanism behind the observed neutraldissociation were obtained.- The details of a new experimental set-up for gas phasefluorescence measurements using synchrotron radiation aredescribed. It is able to perform simultaneous measurements ofdispersed and total fluorescence in the visible range. Thefirst results obtained with this set-up are presented,concerning fluorescence after excitation of the N2 molecules inthe N 1s edge.These four studies conform the set of papers enclosed in theLicentiate thesis.Finally a pre-study to further apply PIFS to speciespreviously excited by microwave discharge is included as futureplans.
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| 10. |
- Álvarez Ruiz, Jesús, 1975-
(författare)
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Synchrotron radiation induced fluorescence spectroscopy of gas phase molecules
- 2004
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- A new experimental set-up for gas phase fluorescence studies using synchrotron radiation has been designed and constructed to perform simultaneously total and dispersed fluorescence measurements. Neutral photodissociation of CO has been investigated after excitation with 19-26 eV photons. Fluorescence from 3p 3P, 3p 3S and 3p 1D excited states in carbon was recorded and interpreted by ab initio calculations. The population and dissociation of states belonging to the C and D Rydberg series in CO seem to explain the production of the observed triplet states but not the 3p 1D state. Neutral photodissociation of NO is reported in the 17-26 eV energy range. No known molecular states can account for the collected data. New information regarding the precursor states of the observed neutral dissociation is provided by ab initio calculations. Autoionization of superexcited states in molecular nitrogen is evidenced by strong deviations of the Franck-Condon ratio in the fluorescence of the N2+ B state. Ab initio calculations predict the existence of autoionizing-excited states that may account for some of the observed structures in the 20-46 eV energy range. Selective molecular fluorescence from the npó1Óu+ and npð 1Ðu (n=3-7) Rydberg levels to the E,F 1Óg+ state in H2 was recorded and rotationally analyzed. Vibrational levels of the E,F 1Óg+ state (vEF =0,1,3,6-10) are determined. The predissociation of npð 1Ð+ levels is observed in agreement with the literature. Fragmentation of SF6 was investigated after excitation with 25–80 eV photons. Dispersed fluorescence measurements reveal the emission of S, S+, F and F+ excited atoms. These fragments are produced after single, double and triple excitations as well as direct ionizations and shake-ups in SF6. Photoabsorption and fluorescence yield have been measured in SF5CF3 using 10-30eV photons. The photoabsorption spectrum can be explained in terms of its similarities to those of the SF6 and CF4 molecules. The dispersed and un-dispersed fluorescence resemble those of the CF3X family. Several features suggest the migration of an F atom across the S-C bond that fragments the molecule producing excited CF4. Doubly excited states of H2 have been investigated in the range of 26-60 eV by monitoring Balmer á emission. The experimental data show the already known emission correlated with the fragmentation of the Q1 and Q2 states, and new features which could be attributed to dissociative photoionization and higher lying doubly excited states Qn (n>2) of the hydrogen molecule
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