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| 2. |
- Ghosh, Tanushree, et al.
(författare)
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Disposable uric acid biosensor by bacterial crude uricase enzyme modified screen printed electrode
- 2015
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Ingår i: Journal of the Indian Chemical Society. - : SCIENTIFIC PUBL-INDIA. - 0019-4522. ; 92:1, s. 127-133
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Tidskriftsartikel (refereegranskat)abstract
- Uric acid is the primary end product from purine derivatives in human metabolism. Excessive production of uric acid may lead to gout, hyperuricemia and kidney disorder: Different analytical methods for uric acid such as Colorimetry, commercial enzyme electrode and commercially available uric acid kit are used widely. The main purpose of this research was to develop,a screen printed electrode based uric acid biosensor using gelatin immobilized uricase enzyme extracted from Comamonas sp. BTUA. The enzyme catalyzed oxidation of uric acid in presence of oxygen, producing allantoin and hydrogen peroxide. The linearity of the standard curve in the concentration ranges from 5.94 x 10(-6) to 4.75 x 10(-4) molar was satisfactory and could be used for the quantitative determination of uric acid in human serum samples. The limit of detection (LOD) was 2.26 mu M and sensitivity was evaluated as 3.31 nA mu M-1 of uric acid. One Modified electrode could be used for six measurements with 95%. accuracy up to 25 days. The developed biosensor was easy to use, inexpensive, sensitive and reliable.
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| 3. |
- Hossain, Md Kamal, et al.
(författare)
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Dioxomolybdenum(VI) complexes of hydrazone phenolate ligands - syntheses and activities in catalytic oxidation reactions
- 2021
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Ingår i: Journal of the Indian Chemical Society. - : Elsevier BV. - 0019-4522. ; 98:2
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Tidskriftsartikel (refereegranskat)abstract
- The new cis-dioxomolybdenum (VI) complexes [MoO2(L2)(H2O)] (2) and [MoO2(L3)(H2O)] (3) containing the tridentate hydrazone-based ligands (H2L2 = N'-(3,5-di-tert-butyl-2-hydroxybenzylidene)-4-methylbenzohydrazide and H2L3 = N'-(2-hydroxybenzylidene)-2-(hydroxyimino)propanehydrazide) have been synthesized and characterized via IR, 1H and 13C NMR spectroscopy, mass spectrometry, and single crystal X-ray diffraction analysis. The catalytic activities of complexes 2 and 3, and the analogous known complex [MoO2(L1)(H2O)] (1) (H2L1 = N'-(2-hydroxybenzylidene)-4-methylbenzohydrazide) have been evaluated for various oxidation reactions, viz. oxygen atom transfer from dimethyl sulfoxide to triphenylphosphine, sulfoxidation of methyl-p-tolylsulfide or epoxidation of different alkenes using tert-butyl hydroperoxide as terminal oxidant. The catalytic activities were found to be comparable for all three complexes, but complexes 1 and 3 showed better catalytic performances than complex 2, which contains a more sterically demanding ligand than the other two complexes.
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| 4. |
- Mishra, Abhishek, et al.
(författare)
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Sustainable chemical preventive models in COVID-19 : Understanding, innovation, adaptations, and impact
- 2021
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Ingår i: Journal of the Indian Chemical Society. - : Elsevier BV. - 0019-4522. ; 98:10
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Tidskriftsartikel (refereegranskat)abstract
- COVID-19 is considered as a major public health problem caused by the SARS CoV-2. This Viral infection is known to induce worldwide pandemic in short period of time. Emerging evidence suggested that the transmission control and drug therapy may influence the preventive measures extensively as the host surrounding environment and pathogenic mechanism may contribute to the pandemic condition earlier in COVID-19 disease. Although, several animals identified as reservoir to date, however human-to-human transmission is well documented. Human beings are sustaining the virus in the communities and act as an amplifier of the virus. Human activities i.e., living with the patient, touching patient waste etc. in the surrounding of active patients or asymptomatic persons cause significant risk factors for transmission. On the other hand, drug target and mechanism to destroy the virus or virus inhibition depends on diversified approaches of drugs and different target for virus life cycle. This article describes the sustainable chemical preventive models understanding, requirements, technology adaptation and the implementation strategies in these pandemic-like situations. As the outbreak progresses, healthcare models focused on transmission control through disinfections and sanitization based on risk calculations. Identification of the most suitable target of drugs and regional control model of transmission are of high priority. In the early stages of an outbreak, availability of epidemiological information is important to encourage preventive measures efforts by public health authorities and provide robust evidence to guide interventions. Here, we have discussed the level of adaptations in technology that research professionals display toward their public health preventive models. We should compile a representative data set of adaptations that humans can consider for transmission control and adopt for viruses and their hosts. Overall, there are many aspects of the chemical science and technology in virus preventive measures. Herein, the most recent advances in this context are discussed, and the possible reasons behind the sustainable preventive model are presented. This kind of sustainable preventive model having adaptation and implementation with green chemistry system will reduce the shedding of the virus into the community by eco-friendly methods, and thus the risk of transmission and infection progression can be mitigated.
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| 5. |
- Pandey, Annu, et al.
(författare)
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Mesoporous carbon-based sensor for quantification of prasugrel in solubilized system
- 2023
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Ingår i: Journal of the Indian Chemical Society. - : Elsevier BV. - 0019-4522. ; 100:9
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Tidskriftsartikel (refereegranskat)abstract
- In this study, a mesoporous carbon-based electrochemical sensor has been made up, possessing the novelty for ultra-sensitive detecting Prasugrel in pharmaceutical formulation and biological samples. Mesoporous carbon has even and tunable pore size, greater surface area, with excellent, electrical conductivity, wide availability and also have unique surface functionalization properties which make them significant sensing material now a days. Determination of prasugrel was accomplished with mesoporous carbon/GCE sensor on square-wave and cyclic voltammetry. Effects of various environmental and instrumental parameters like effect of buffer, casting volume, solvent, and pH on peak signal have been optimized. The best results were obtained in 0.1% cetyltrimethylammonium bromide - aqueous 0.1 M potassium chloride–phosphate buffer (pH 5.3). The limit of detection and quantification of the pure drug was found to be 37.0 ng mL−1 and 110.0 ng mL−1 (with the correlation coefficient, r = 0.988 and the standard deviation, (S.D.) = 0.6 (n = 6), respectively. The fabricated sensor was efficaciously validated by the determination of the drug in pharmaceutical formulation. Recoveries obtained were 97.84–99.37%.
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