| 1. |
- Bisgin, Atil, et al.
(författare)
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Serum soluble tumour necrosis factor related apoptosis-inducing ligand level and peripheral eosinophil count in patients with nasal polyposis
- 2015
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Ingår i: Journal of Laryngology and Otology. - : Cambridge University Press (CUP): STM Journals. - 0022-2151 .- 1748-5460. ; 129:3, s. 250-253
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Tidskriftsartikel (refereegranskat)abstract
- Background: Nasal polyposis is one of the most common inflammatory pathologies of the nasal cavity. Eosinophilic inflammation plays an important role in the pathogenesis. This study aimed to investigate soluble tumour necrosis factor related apoptosis-inducing ligand levels and eosinophil count in nasal polyposis patients. Methods: The study was performed on 24 adult nasal polyposis patients and 24 age-matched healthy individuals. The patients had not received any medical or surgical treatment. Pre-operative computed tomography scans were assessed using the Lund-MacKay grading system, and soluble tumour necrosis factor related apoptosis-inducing ligand levels were measured with a sandwich enzyme-linked immunosorbent assay. Results: Compared with controls, eosinophil levels in nasal polyposis patients were increased (p = 0.024), but there was no significant difference in soluble tumour necrosis factor related apoptosis-inducing ligand levels (p = 0.529). The Lund-Mackay mean grading was 12.43 +/- 6.9. There was no correlation between soluble tumour necrosis factor related apoptosis-inducing ligand level and Lund-Mackay grading and eosinophil count. Conclusion: There was no relationship between soluble tumour necrosis factor related apoptosis-inducing ligand level and blood eosinophil or clinical markers; however, soluble tumour necrosis factor related apoptosis-inducing ligand level remains of interest for future studies.
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| 2. |
- Blomstedt, Patric
(författare)
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Tracheostomy in ancient Egypt
- 2014
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Ingår i: Journal of Laryngology and Otology. - 0022-2151 .- 1748-5460. ; 128:8, s. 665-668
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Forskningsöversikt (refereegranskat)abstract
- It has often been reported that the ancient Egyptians performed tracheostomies. An analysis of this claim demonstrates it to be founded on only two depictions from the Protodynastic period (thirty-first century BC). These depictions are difficult to reconcile with tracheostomy from an anatomical point of view and can more easily be explained as human sacrifices. Considering that Egyptian surgery included only minor procedures even at its zenith during later dynastic periods, it is difficult to imagine that they would have developed such an advanced procedure at such an early date.
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| 3. |
- Dawson, Blake, et al.
(författare)
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The effects of nasal lavage with betamethasone cream post-endoscopic sinus surgery : clinical trial
- 2018
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Ingår i: Journal of Laryngology and Otology. - 0022-2151. ; 132:2, s. 143-149
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Tidskriftsartikel (refereegranskat)abstract
- Background: Steroid nasal irrigation for chronic rhinosinusitis patients following endoscopic sinus surgery reduces symptom recurrence. There are minimal safety data to recommend this treatment. This study evaluated the safety of betamethasone nasal irrigation by measuring its impact on endogenous cortisol levels. Methods: Participants performed daily betamethasone nasal irrigation for six weeks. The impact on pre- and post-intervention serum and 24-hour urinary free cortisol was assessed. Efficacy was evaluated using the 22-item Sino-Nasal Outcome Test. Results: Thirty participants completed the study (16 females and 14 males; mean age = 53.9 ± 15.6 years). Serum cortisol levels were unchanged (p = 0.28). However, 24-hour urinary free cortisol levels decreased (47.5 vs 41.5 nmol per 24 hours; p = 0.025). Sino-Nasal Outcome Test scores improved (41.13 ± 21.94 vs 23.4 ± 18.17; p < 0.001). The minimal clinical important difference was reached in 63 per cent of participants. Conclusion: Daily betamethasone nasal irrigation is an efficacious treatment modality not associated with changes in morning serum cortisol levels. The changes in 24-hour urinary free cortisol levels are considered clinically negligible. Hence, continued use of betamethasone nasal irrigation remains a viable and safe treatment option for chronic rhinosinusitis patients following functional endoscopic sinus surgery.
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| 4. |
- Diamant, H, et al.
(författare)
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Swedish otorhinolaryngology (ORL) 1880-1920
- 2005
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Ingår i: The Journal of laryngology and otology. Supplement. - : Cambridge University Press (CUP). - 0144-2945 .- 0022-2151 .- 1748-5460. ; 119:30, s. 104-106
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Tidskriftsartikel (refereegranskat)
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| 5. |
- Emgård, Per, et al.
(författare)
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A group III steroid solution without antibiotic components : an effective cure for external otitis.
- 2005
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Ingår i: Journal of Laryngology and Otology. - : Cambridge University Press (CUP). - 0022-2151 .- 1748-5460. ; 119:5, s. 342-7
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Tidskriftsartikel (refereegranskat)abstract
- The present study was undertaken to compare the clinical benefits of prescribing ear drops containing 0.05% solution of betamethasone dipropionate (BD), and ear drops containing hydrocortisone with oxytetracycline hydrochloride and polymyxin B (HCPB), for topical treatment of external otitis. Fifty-one patients were enrolled in this open randomized, parallel-group, multicentre study, performed in eight different ENT departments. The patients were randomly assigned to one of the two treatment groups: BD (n = 26) and HCPB (n = 25). Only ENT specialists investigated the patients. Bacterial and fungal cultures were raised on days 1 and 11, using swabbed material from ear canals. Twice daily the patients recorded their symptoms during the acute phase, using special diary cards.BD proved a significantly more effective cure than HCPB during the acute phase of external otitis and afforded a lower relapse frequency during a six-month follow-up period. The patients of the BD group were significantly less troubled by itching (p < 0.01) than those in the HCPB group. On day 11, at the end of the acute phase, growth of bacteria (p = 0.03) and fungi (p < 0.01) was less frequent in the BD group than in the HCPB group. No serious adverse events occurred, and those minor events observed were comparable between the two groups.Our conclusion is that the group III steroid solution, BD, cured the external otitis more effectively than did the HCPB solution, whether infected by bacteria or by fungi. No difference was evident regarding adverse effects. Furthermore, price favours a solution without any antibiotic component. In view of these observations, a group III steroid solution ought to be the preferred remedy for external otitis, whether infected or not.
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| 6. |
- Geneid, A., et al.
(författare)
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Union of the European Phoniatricians position statement on the exit strategy of phoniatric and laryngological services: staying safe and getting back to normal after the peak of coronavirus disease 2019 (issued on 25th May 2020)
- 2020
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Ingår i: Journal of Laryngology and Otology. - : CAMBRIDGE UNIV PRESS. - 0022-2151 .- 1748-5460. ; 134:8, s. 661-664
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Tidskriftsartikel (refereegranskat)abstract
- Background The following position statement from the Union of the European Phoniatricians, updated on 25th May 2020 (superseding the previous statement issued on 21st April 2020), contains a series of recommendations for phoniatricians and ENT surgeons who provide and/or run voice, swallowing, speech and language, or paediatric audiology services. Objectives This material specifically aims to inform clinical practices in countries where clinics and operating theatres are reopening for elective work. It endeavours to present a current European view in relation to common procedures, many of which fall under the aegis of aerosol generating procedures. Conclusion As evidence continues to build, some of the recommended practices will undoubtedly evolve, but it is hoped that the updated position statement will offer clinicians precepts on safe clinical practice.
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| 7. |
- Hallgren, Frida, et al.
(författare)
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Antibiotics in treatment of peritonsillar infection: clindamycin versus penicillin
- 2021
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Ingår i: Journal of Laryngology and Otology. - : Cambridge University Press (CUP). - 0022-2151. ; 135:1, s. 64-69
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Tidskriftsartikel (refereegranskat)abstract
- Objective This study aimed to compare antibiotic treatment with clindamycin versus penicillin V or G in terms of time to recovery and recurrence in patients with peritonsillar infection, including both peritonsillar cellulitis and peritonsillar abscess. Method This retrospective cohort study examined the records of 296 patients diagnosed with peritonsillar infection. Based on the ENT doctor's choice of antibiotics, patients were divided into clindamycin and penicillin groups. Results Mean number of days in follow up was 3.5 days in the clindamycin group and 3.4 days in the penicillin group. The recurrence rate within 2 months was 7 per cent in the clindamycin group and 4 per cent in the penicillin group. Conclusion This study found no significant differences in either recovery or recurrence between the groups. This supports the use of penicillin as a first-line treatment, considering the greater frequency of adverse effects of clindamycin shown in previous studies, as well as its profound collateral damage on the intestinal microbiota, resulting in antibiotic resistance.
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| 8. |
- Heo, S J, et al.
(författare)
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Stability measurements of craniofacial implants by means of resonance frequency analysis. A clinical pilot study.
- 1998
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Ingår i: The Journal of laryngology and otology. - : Cambridge University Press (CUP). - 0022-2151 .- 1748-5460. ; 112:6, s. 537-42
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Tidskriftsartikel (refereegranskat)abstract
- Nineteen patients previously treated with 52 implants for anchorage of craniofacial prostheses were subjected to implant stability measurements by means of resonance frequency analysis (RFA), six months to 15 years after implant placement. The resonance frequency (RF) of a transducer attached to the implant abutment was measured by using a frequency response analyser, a personal computer (PC) and dedicated software. Statistically significant higher RF values were seen for implants in the temporal bone as compared to implants in the nose and periorbital regions. There was a positive correlation with time since implant placement for the period from six months up to seven years. It was concluded that the preliminary results suggest that implant stability increases with time and that implants in temporal bone are more stable than implants in the bone in the nose and periorbital regions, probably reflecting differences in bone density.
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| 9. |
- Hydén, Dag, 1945-, et al.
(författare)
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Ear involvement in ligneous conjunctivitis : A rarity or an under-diagnosed condition?
- 2002
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Ingår i: Journal of Laryngology and Otology. - : Cambridge University Press (CUP). - 0022-2151 .- 1748-5460. ; 116:6, s. 482-487
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Tidskriftsartikel (refereegranskat)abstract
- Conjunctivitis lignosa, a rare affliction of the conjunctiva, is sometimes associated with other disturbances. We present two children with concurrent conjunctivitis lignosa and ear involvement. In these two cases, there were histopathologically verified ligneous changes of the middle ears. Routine haematoxylin and eosin, van Gieson, periodic acid-Schiff (PAS) and alcian blue staining of specimens from the eyes and middle ears revealed findings typical for ligneous conjunctivitis. In addition, new histochemical and immunohistochemical studies for glycosaminoglycans on specimens from the eyes and middle ears showed that the accumulations of the amorphous, cell-deficient material stained strongly but heterogeneously for hyaluronic acid and weakly but uniformly for keratin sulphate. The staining for other glycosaminoglycans, e.g. chondroitin-4-sulphate and dermatan sulphate was confined to vessels and areas rich in collagen fibres and fibroblasts. In patients with conjunctivitis lignosa, the ear involvement may remain undiagnosed due to its resemblance to secretory otitis media with effusion. Since isolated ear involvement may occur, we advocate biopsies for routine haematoxylin and eosin, and specific staining for hyaluronic acid and keratin sulphate, also in children with protracted, refractory otitis media with atypical effusion.
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| 10. |
- Karlsson, A., et al.
(författare)
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Total nasal airway resistance while sitting predicts airway collapse when lying down
- 2020
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Ingår i: Journal of Laryngology and Otology. - 0022-2151. ; 134:10, s. 917-924
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Tidskriftsartikel (refereegranskat)abstract
- Background Nasal obstruction when lying down is a common complaint in patients with chronic nasal obstruction, but rhinomanometry is typically performed in the sitting position. This study aimed to analyse whether adding rhinomanometry in a supine position is a useful examination. Method A total of 41 patients with chronic nasal obstruction underwent rhinomanometry and acoustic rhinometry, sitting and supine, before and after decongestion, as well as an over-night polygraphy. Results Total airway resistance was measurable in a supine position in 48 per cent (14 of 29) of the patients with total airway resistance of equal to or less than 0.3 Pa/cm3/second when sitting and in none (0 of 12) of the patients with total nasal airway resistance of more than 0.3 Pa/cm3/second when sitting. After decongestion, this increased to 83 per cent and 58 per cent, respectively. Conclusion Increased nasal resistance when sitting predicts nasal breathing problems when supine. Rhinomanometry in a supine position should be performed to diagnose upper airway collapse when supine. Copyright © JLO (1984) Limited, 2020.
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