| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Saeed, Sahrai, et al.
(författare)
-
Ventricular-arterial coupling as a potential therapeutic target in diabetes
- 2021
-
Ingår i: Journal of the Pakistan Medical Association. - 0030-9982. ; 71:11, s. 2637-2640
-
Forskningsöversikt (refereegranskat)abstract
- Patients with type 2 diabetes (T2D) are at high risk of cardiovascular complications. Novel anti-diabetic medications such as sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and Glucagon-like peptide-1 receptor agonists (GLP-1RA) have been shown to possess cardiac and renal protective effects beyond their ability to lower plasma glucose. Use of SGLT-2i and GLP-1RA in patients with T2D and heart failure reduce cardiovascular risk and heart failure-related hospitalisations. SGLT-2i treatment has been shown to improve the long-term prognosis of patients with heart failure. Both drugs also have the potential to normalise ventricular-arterial coupling (VAC). VAC is the crosstalk between the left ventricular function and arterial system, and is an indicator of the global cardiovascular performance. In this overview, we will describe the concept of VAC and the features of diabetic cardiomyopathy, as well as VAC as a potential therapeutic target in diabetes by the use of novel anti-diabetic drugs, primarily SGLT-2i and GLP-1RA.
|
|
| 6. |
|
|
| 7. |
- Urooj, Faiza, et al.
(författare)
-
Socio-demographic characteristics of children and young people with primary brain tumours : comparison between a public and private sector tertiary hospital in Karachi, Pakistan
- 2024
-
Ingår i: JOURNAL OF PAKISTAN MEDICAL ASSOCIATION. - : Pakistan Medical Association. - 0030-9982. ; 74:2, s. 366-369
-
Tidskriftsartikel (refereegranskat)abstract
- Primary brain tumours (PBTs) are the commonest solid tumours in children and young people (CYP). A study was conducted at a private and a public sector hospital in Karachi, Pakistan, to determine the socio-demographic and tumour -related characteristics of CYP with PBTs between those presenting to the public and private hospitals. A total of 49 patients were included. The commonest PBT was pilocytic astrocytoma (29%). There were no differences in tumour -related characteristics between the two groups. However, parents of CYP with PBTs presenting to the public sector hospital were significantly less educated and had lower household incomes. No significant differences in age, gender, educational status, and ethnicity of CYP with PBTs were observed. Since CYP with PBTs presenting at the public sector hospital were from significantly lower socioeconomic backgrounds and their parents were less educated, it suggests socio-economic disparities in PBT care for CYPs in Karachi, Pakistan.
|
|
