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- Hedman, Katarina, et al.
(author)
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The Effect of Latanoprost on Intraocular Pressure During 2 Years of Treatment
- 2002
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In: Survey of ophthalmology. - 0039-6257 .- 1879-3304. ; 47:S1, s. 65-76
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Journal article (peer-reviewed)abstract
- Our objective was to study the intraocular pressure (IOP) in open-angle glaucoma or ocular hypertensive patients during long-term treatment with latanoprost. A total of 532 patients treated with 0.005% latanoprost were enrolled, including 493 and 113 patients treated for 6 and 24 months, respectively. Mean IOP was analyzed with the analysis of variance technique. The risk of treatment failure was analyzed with survival analysis technique. After 2 weeks of latanoprost treatment, the mean IOP was reduced 8.2 (32%) and 8.9 (34%) mm Hg in the subgroups of patients treated for 6 and 24 months, respectively. The change in mean IOP during 2 years of latanoprost treatment was not statistically significant (p = 0.15). Patients with primary open-angle glaucoma or ocular hypertension showed an 86% and 97% chance of receiving a sufficient IOP reduction with latanoprost (p < 0.01), repectively. The initial mean IOP reduction was maintained throughout the 2 years of treatment.
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- Schuster, V, et al.
(author)
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Ligneous conjunctivitis
- 2003
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In: Survey of ophthalmology. - : Elsevier BV. - 0039-6257. ; 48:4, s. 369-388
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Journal article (peer-reviewed)
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- Seregard, S
(author)
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Conjunctival melanoma
- 1998
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In: Survey of ophthalmology. - 0039-6257. ; 42:4, s. 321-350
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Journal article (peer-reviewed)
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- Alm, Albert, et al.
(author)
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Side effects associated with prostaglandin analog therapy
- 2008
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In: Survey of ophthalmology. - : Elsevier BV. - 0039-6257 .- 1879-3304. ; 53:Suppl. 1, s. S93-S105
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Research review (peer-reviewed)abstract
- Topical prostaglandin analogs, which have become first-line therapy in the medical management of glaucoma, have an excellent safety profile with regard to systemic side effects, but are associated with several ocular side effects. Some of these are common, with no apparent serious consequences other than cosmetic, whereas others are much less common but represent potentially sight-threatening side effects. The former group includes conjunctival hyperemia, elongation and darkening of eyelashes, induced iris darkening, and periocular skin pigmentation. The latter group of side effects, which are relatively rare and lack definitive causal relationship to prostaglandin analog therapy, includes iris cysts, cystoid macular edema, anterior uveitis, and reactivation of herpes simplex keratitis. Most of the literature regarding side effects associated with prostaglandin analogs involves the use of latanoprost, probably because it was the first to be studied. There is no evidence, however, aside from less conjunctival hyperemia with latanoprost, that the commercially available prostaglandin analogs differ significantly with regard to side effects.
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- Chiquet, Christophe, et al.
(author)
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Acute postoperative endophthalmitis : Microbiology from the laboratory to the bedside
- 2022
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In: Survey of Ophthalmology. - : Elsevier BV. - 0039-6257. ; 67:6, s. 1698-1710
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Research review (peer-reviewed)abstract
- Postoperative endophthalmitis is a dreaded complication of intraocular surgery. Acute presentations need prompt management and good knowledge of differential diagnoses. In the last 10 years, progress in direct microbial detection and identification from intraocular samples included the use of blood culture systems and, more recently, matrix-assisted laser desorption ionization time-of-flight mass spectrometry, improving the rate of bacterial identification. Whatever the method used, diagnostic sensitivity is better for vitreous samples than for aqueous humor samples. Besides, molecular biology techniques have further improved the identification rate of infectious agents in intraocular samples. They also provide faster results compared to culture-based techniques. Quantitative real-time PCR (qPCR) can also determine the bacterial load in intraocular samples. Several studies have shown that intraocular bacterial loads in endophthalmitis patients are usually high, which helps differentiating infection from contamination. The prognostic value of qPCR remains to be validated. Whole genome DNA sequencing technologies facilitate direct and sequencing of single DNA molecules. They have the potential to increase the rate of microbiological identification. Some antibiotic resistance markers (e.g., methicillin resistance in staphylococci and vancomycin resistance in enterococci) may be detected earlier using molecular techniques (usually real-time PCR tests). Early determination of the involved microorganism and their antibiotic resistances can help establishing an earlier therapeutic strategy.
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- Hedman, Katarina, et al.
(author)
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The effect of latanoprost compared with timolol in African-American, Asian, European, Mexican and US glaucoma or ocular hypertensive patients
- 2002
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In: Survey of ophthalmology. - 0039-6257 .- 1879-3304. ; 47:4S1, s. 77-89
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Journal article (peer-reviewed)abstract
- OBJECTIVE:To study the intraocular pressure (IOP) reduction of latanoprost or timolol in a heterogeneous global population.METHODS:A total of 1,389 glaucoma or ocular hypertensive patients treated with 0.005% latanoprost once daily (n = 737) or 0.5% timolol twice daily (n = 652) from eight clinical trials were included. After 3-6 months of treatment, the IOP was analyzed with use of analysis of covariance.RESULTS:Latanoprost or timolol gave statistically significant mean diurnal IOP reduction in the African-American, Asian, Caucasian, and Mexican patients, latanoprost with 7.9 mm Hg and timolol with 6.4 mm Hg. The Asian and Mexican patients showed a larger difference in mean diurnal IOP reduction with use of the two drugs (range 1.8-3.1 mm Hg) than the European and U.S. patients (range 0.6-1.7 mm Hg, p = 0.030). Latanoprost produced similar mean diurnal IOP reduction in patients with and without previous glaucoma treatment other than prostaglandins.CONCLUSION:Latanoprost or timolol statistically significantly reduced the mean diurnal IOP in a heterogenous global population in eight clinical trials. The degree of reduction appeared to be clinically useful. The greatest difference in the mean diurnal IOP-lowering effect of latanoprost or timolol was observed in Mexican and Asian clinical trials.
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