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| 2. |
- Mårtensson, Frida, et al.
(författare)
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Modeling the meaning of words : Neural correlates of abstract and concrete noun processing
- 2011
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Ingår i: Acta Neurobiologiae Experimentalis. - 0065-1400 .- 1689-0035. ; 71:4, s. 455-478
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Tidskriftsartikel (refereegranskat)abstract
- We present a model relating analysis of abstract and concrete word meaning in terms of semantic features and contextual frames within a general framework of neurocognitive information processing. The approach taken here assumes concrete noun meanings to be intimately related to sensory feature constellations. These features are processed by posterior sensory regions of the brain, e.g. the occipital lobe, which handles visual information. The interpretation of abstract nouns, however, is likely to be more dependent on semantic frames and linguistic context. A greater involvement of more anteriorly located, perisylvian brain areas has previously been found for the processing of abstract words. In the present study, a word association test was carried out in order to compare semantic processing in healthy subjects (n=12) with subjects with aphasia due to perisylvian lesions (n=3) and occipital lesions (n=1). The word associations were coded into different categories depending on their semantic content. A double dissociation was found, where, compared to the controls, the perisylvian aphasic subjects had problems associating to abstract nouns and produced fewer semantic frame-based associations, whereas the occipital aphasic subject showed disturbances in concrete noun processing and made fewer semantic feature based associations.
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| 3. |
- Nersisyan, Syune, et al.
(författare)
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Cholinergic modulation of synaptic properties of cortical layer VI input to posteromedial thalamic nucleus of the rat investigated in vitro
- 2012
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Ingår i: Acta Neurobiologiae Experimentalis. - 0065-1400 .- 1689-0035. ; 72:4, s. 461-467
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Tidskriftsartikel (refereegranskat)abstract
- The second order somatosensory thalamic nucleus (posteromedial nucleus, PoM) receives excitatory projection from layer VI of somatosensory cortex. While it is known that layer VI cortical input to first order, ventrobasal nucleus (VB) is modulated by cholinergic projections from the brainstem, no such data exists concerning the PoM nucleus. In order to study if layer VI corticothalamic transmission to PoM is also modulated we used patch-clamp recording in thalamocortical slices from the rat's brain. Excitatory postsynaptic potentials (EPSPs) were evoked in PoM cells by trains of 5 electrical pulses at 20 Hz frequency applied to corticothalamic fibers. After carbachol was applied to mimic activation of the cholinergic neuromodulatory system corticothalamic EPSP amplitudes were reduced, while facilitation of EPSP amplitudes was enhanced for each next pulse in the series. Such cholinergic control of layer VI corticothalamic synapses in PoM may be used as gain modulator for the transfer of the peripheral sensory information to the cortex.
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| 4. |
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| 5. |
- Gut, M, et al.
(författare)
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Brain correlates of right-handedness
- 2007
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Ingår i: Acta neurobiologiae experimentalis. - 0065-1400. ; 67:1, s. 43-51
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Tidskriftsartikel (refereegranskat)
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| 9. |
- Addario, Barbara, et al.
(författare)
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The domain structure of Entamoeba α-actinin2
- 2010
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Ingår i: Cellular & Molecular Biology Letters (Druk). - : Springer. - 1425-8153 .- 1689-1392. ; 15:4, s. 665-78
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Tidskriftsartikel (refereegranskat)abstract
- Entamoeba histolytica, a major agent of human amoebiasis, expresses two distinct forms of α-actinin, a ubiquitous actin-binding protein that is present in most eukaryotic organisms. In contrast to all metazoan α-actinins, in both isoforms the intervening rod domain that connects the N-terminal actin-binding domain with the C-terminal EF-hands is much shorter. It is suggested that these α-actinins may be involved in amoeboid motility and phagocytosis, so we cloned and characterised each domain of one of these α-actinins to better understand their functional role. The results clearly showed that the domains have properties very similar to those of conventional α-actinins.
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| 10. |
- Wienberg, Jes, et al.
(författare)
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Europeanisation at the Baltic Sea : a Counterfactual Perspective
- 2009
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Ingår i: The Reception of Medieval Europe in the Baltic Sea Region : Papers of the XIIth Visby Symposium held at Gotland University, Visby - Papers of the XIIth Visby Symposium held at Gotland University, Visby. - 0065-1702. - 9197365351 ; 12, s. 421-429
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- A counterfactual perspective on the development at the Europeanisation at the Baltic Sea between 1100 and 1400.
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