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| 2. |
- Ahmetov, II, et al.
(författare)
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Current Progress in Sports Genomics
- 2015
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Ingår i: Advances in clinical chemistry. - : Elsevier. - 0065-2423. ; 70, s. 247-314
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Tidskriftsartikel (refereegranskat)
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| 4. |
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| 5. |
- Glasdam, Sidsel-Marie, et al.
(författare)
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The Importance of Magnesium in the Human Body: A Systematic Literature review
- 2016
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Ingår i: Advances in Clinical Chemistry. - : Elsevier. - 0065-2423. - 9780128046906 ; 73, s. 169-193
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Bokkapitel (refereegranskat)abstract
- Magnesium, the second and fourth most abundant cation in the intracellular compartment and whole body, respectively, is of great physiologic importance. Magnesium exists as bound and free ionized forms depending on temperature, pH, ionic strength, and competing ions. Free magnesium participates in many biochemical processes and is most commonly measured by ion-selective electrode. This analytical approach is problematic because complete selectivity is not possible due to competition with other ions, i.e., calcium, and pH interference. Unfortunately, many studies have focused on measurement of total magnesium rather than its free bioactive form making it difficult to correlate to disease states. This systematic literature review presents current analytical challenges in obtaining accurate and reproducible test results for magnesium. © 2016 Elsevier Inc.
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| 6. |
- Philippou, Anastassios, et al.
(författare)
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Cytokines in muscle damage
- 2012
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Ingår i: Advances in Clinical Chemistry. - 0065-2423 .- 2162-9471. ; 58, s. 49-87
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Tidskriftsartikel (refereegranskat)abstract
- Multiple cellular and molecular processes are rapidly activated following skeletal muscle damage to restore normal muscle structure and function. These processes typically involve an inflammatory response and potentially the consequent occurrence of secondary damage before their resolution and the completion of muscle repair or regeneration. The overall outcome of the inflammatory process is potentially divergent, with the induction of prolonged inflammation and further muscle damage, or its active termination and the promotion of muscle repair and regeneration. The final, detrimental, or beneficial effect of the inflammatory response on muscle repair is influenced by specific interactions between inflammatory and muscle cell-derived cytokines that act as positive and/or negative regulators to coordinate local and systemic inflammatory-related events and modulate muscle repair process. A crucial balance between proinflammatory and anti-inflammatory cytokines appears to attenuate an excessive inflammatory reaction, prevent the development of muscle fibrosis, and adequately promote the regenerative process. In this review, we address the interactive cytokine responses following muscle damage, in the context of induction and progression, or resolution of muscle inflammation and the promotion of muscle repair.
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| 7. |
- Simrén, Joel, 1996, et al.
(författare)
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Fluid biomarkers in Alzheimer's disease
- 2022
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Ingår i: Advances in Clinical Chemistry. - : Elsevier. - 0065-2423. ; , s. 249-281
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Bokkapitel (refereegranskat)abstract
- Alzheimer's disease (AD) characterization has progressed from being indexed using clinical symptomatology followed by neuropathological examination at autopsy to in vivo signatures using cerebrospinal fluid (CSF) biomarkers and positron emission tomography. The core AD biomarkers reflect amyloid-β plaques (A), tau pathology (T) and neurodegeneration (N), following the ATN schedule, and are now being introduced into clinical routine practice. This is an important development, as disease-modifying treatments are now emerging. Further, there are now reproducible data on CSF biomarkers which reflect synaptic pathology, neuroinflammation and common co-pathologies. In addition, the development of ultrasensitive techniques has enabled the core CSF biomarkers of AD pathophysiology to be translated to blood (e.g., phosphorylated tau, amyloid-β and neurofilament light). In this chapter, we review where we stand with both core and novel CSF biomarkers, as well as the explosion of data on blood biomarkers. Also, we discuss potential applications in research aiming to better understand the disease, as well as possible use in routine clinical practice and therapeutic trials.
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| 8. |
- Zetterberg, Henrik, 1973, et al.
(författare)
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CSF in Alzheimer's Disease
- 2014
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Ingår i: Advances in Clinical Chemistry. - San Diego : Elsevier Academic Press Inc. - 0065-2423. ; 65, s. 143-172
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Forskningsöversikt (refereegranskat)abstract
- Alzheimer's disease (AD) is a progressive brain amyloidosis that injures brain regions involved in memory consolidation and other cognitive functions. Neuropathologically, the disease is characterized by accumulation of a 42-amino acid protein called amyloid beta, and N-terminally truncated fragments thereof, in extracellular senile plaques together with intraneuronal inclusions of hyperphosphorylated tau protein in neurofibrillary tangles, and neuronal and axonal degeneration and loss. Clinical chemistry tests for these pathologies have been developed for use on cerebrospinal fluid samples. Here, we review what these markers have taught us on the disease process in AD and how they can be implemented in routine clinical chemistry. We also provide an update on new marker development and ongoing analytical standardization effort.
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