| 1. |
- Björklund, Erland, et al.
(författare)
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Pressurised liquid extraction of persistent organic pollutants in environmental analysis
- 2000
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Ingår i: TrAC - Trends in Analytical Chemistry. - 0165-9936. ; 19:7, s. 434-445
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Forskningsöversikt (refereegranskat)abstract
- This review updates our knowledge on pressurised liquid extraction, PLE (also known as accelerated solvent extraction and pressurised fluid extraction) of persistent organic pollutants such as polynuclear aromatic hydrocarbons and polychlorinated biphenyls from environmental matrices. The basic experimental set-up is presented, and parameters influencing the extraction process are discussed. PLE can be used for a broad range of applications, and clearly has the potential for replacing tedious classic extraction methods such as Soxhlet extraction. Copyright (C) 2000 Elsevier Science B.V.
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| 2. |
- Laurell, Thomas, et al.
(författare)
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Proteomics-protein profiling technology: the trend towards a microfabricated toolbox concept
- 2001
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Ingår i: Trac. Trends in Analytical Chemistry. - : Elsevier BV. - 0165-9936. ; 20:5, s. 225-231
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Tidskriftsartikel (refereegranskat)abstract
- The use of mono-crystalline silicon microstructures for high-speed and high sensitivity protein mapping and protein identification is presented as an important contribution within the field of proteomics. The various approaches for handling minute amounts of protein sample are described. Piezoelectric dispensing units developed in-house are being used for sample-handling and the generation of 60-pl droplets, interfacing with high-density microchip MALDI-TOF MS target plates having an array density of 4000 nanovials/square inch. Examples of applications to microtechnology, and future trends in our research are outlined. (C) 2001 Elsevier Science B.V. All rights reserved.
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| 3. |
- Xie, Bin, et al.
(författare)
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Mini/micro thermal biosensors and other related devices for biochemical/clinical analysis and monitoring
- 2000
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Ingår i: TrAC - Trends in Analytical Chemistry. - 0165-9936. ; 19:5, s. 340-349
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Tidskriftsartikel (refereegranskat)abstract
- The present review discusses the recent developments in the design, fabrication and implementation of mini/micro thermal biosensors for biochemical/clinical analysis and monitoring. The principle of thermometric sensing and recent developments in microfabrication technology are introduced, followed by their adaptation to thermometric devices. The instrumentation of the mini, micro and multisensing thermometric devices are described followed by their application to a variety of biochemical/clinical analyses. Other developments in material design and hybrid devices for thermometric sensing are also mentioned.
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| 4. |
- Owens, Paul K., et al.
(författare)
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Molecular imprinting for bio- and pharmaceutical analysis
- 1999
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Ingår i: TrAC. Trends in analytical chemistry. - Amsterdam : Elsevier. - 0165-9936 .- 1879-3142. ; 18:3, s. 146-154
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Tidskriftsartikel (refereegranskat)abstract
- The potential of analytical techniques based on molecular imprinting is reviewed from the viewpoint of bio- and pharmaceutical analysis. A literature study shows that molecularly imprinted polymers (MIPs) have been implemented predominantly in three areas of interest to pharmaceutical industry laboratories. First, in sample preparation, imprinted polymers are used as the sorbent for solid phase extraction purposes. Secondly, MIPs serve as the stationary phase for analytical chromatographic and electrophoretic separations. Thirdly, imprinted polymers are utilised as analyte recognition materials in affinity assays. The advantages of MIPs, e.g., physical robustness, high strength, resistance to elevated temperatures and pressures, and inertness towards acids, bases, metal ions and organic solvents, have been well exploited in a large number of applications. This article focuses on how these benefits may be used for improving the quality of analytical procedures. Some key MIP disadvantages are also highlighted, especially in relation to other analytical techniques. (C) 1999 Published by Elsevier Science B.V. All rights reserved.
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| 5. |
- Abalos, M., et al.
(författare)
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Results for PCDD/PCDF and dl-PCBs in the first round of UNEPs biennial global interlaboratory assessment on persistent organic pollutants
- 2013
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Ingår i: TrAC. Trends in analytical chemistry. - : Elsevier BV. - 0165-9936 .- 1879-3142. ; 46, s. 98-109
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Tidskriftsartikel (refereegranskat)abstract
- The first worldwide interlaboratory assesment on persistent organic pollutants (POPs) under the Stockholm Convention was organized in the Asian/Pacific, Latin American and African regions during 2009-11.A relatively large number of laboratories reported data for the PCDDs/PCDFs and dioxin-like PCBs, especially in the Asian region. Within the Asian region, several participants used high-resolution GC/high-resolution MS systems optimized for dioxin analysis. The availibility of High-resolution mass spectrometer instrumentation is limited in the Latin America and African regions, although recently several new laboratories for dioxins have started in the Latin American region.
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| 6. |
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| 7. |
- Ahlström, Lars-Henric, et al.
(författare)
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Determination of banned azo dyes in consumer goods
- 2005
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Ingår i: Trac. Trends in Analytical Chemistry. - : Elsevier BV. - 0165-9936. ; 24:1, s. 49-56
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Tidskriftsartikel (refereegranskat)abstract
- Azo dyes, extensively used for coloring a variety of consumer goods, such as leather, clothes, food, and toys, can under certain conditions be reduced to form confirmed or suspected carcinogenic aromatic amines. This article gives an overview of the state of development of analytical procedures for the determination of such azo dyes, which are banned by the European Commission. (C) 2004 Elsevier Ltd. All rights reserved.
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| 8. |
- Ahrens, Lutz
(författare)
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Harmonized quality assurance/quality control provisions to assess completeness and robustness of MS1 data preprocessing for LC-HRMS-based suspect screening and non-targeted analysis
- 2024
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Ingår i: Trends in Analytical Chemistry. - 0165-9936. ; 174
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Forskningsöversikt (refereegranskat)abstract
- Non-targeted and suspect screening analysis using liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) holds great promise to comprehensively characterize complex chemical mixtures. Data preprocessing is a crucial part of the process, however, some limitations are observed: (i) peak-picking and feature extraction might be incomplete, especially for low abundant compounds, and (ii) limited reproducibility has been observed between laboratories and software for detected features and their relative quantification. We first conducted a critical review of existing solutions that could improve the reproducibility of preprocessing for LC-HRMS. Solutions include providing repositories and reporting guidelines, open and modular processing workflows, public benchmark datasets, tools to optimize the data preprocessing and to filter out false positive detections. We then propose harmonized quality assurance/quality control guidelines that would allow to assess the sensitivity of feature detection, reproducibility, integration accuracy, precision, accuracy, and consistency of data preprocessing for human biomonitoring, food and environmental communities.
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| 9. |
- Allan, Ian J., et al.
(författare)
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Strategic monitoring for the European Water Framework Directive
- 2006
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Ingår i: TrAC - Trends in Analytical Chemistry. - : Elsevier BV. - 0165-9936. ; 25:7, s. 704-715
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Tidskriftsartikel (refereegranskat)abstract
- This article first reviews the principal monitoring requirements of the Water Framework Directive (WFD) of the European Union (EU) and assesses how contaminant monitoring may fit into a risk-assessment approach. In this context, we show the limited ability of conventional trace-contaminant-monitoring methods to fulfil all of the WFD requirements. We then clearly define and exemplify the roles and the functions of a new set of monitoring tools, using three case studies based on datasets that we obtained during a field trial in the River Meuse as part of the Screening methods for Water data InFormaTion (SWIFT-WFD) project in support of implementing the WFD.
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| 10. |
- Andersson, Anna, et al.
(författare)
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Extending the potential of Fourier transform ion cyclotron resonance massspectrometry for the analysis of disinfection by-products
- 2023
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Ingår i: TrAC. Trends in analytical chemistry. - : ELSEVIER SCI LTD. - 0165-9936 .- 1879-3142. ; 167
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Forskningsöversikt (refereegranskat)abstract
- Potentially harmful disinfection by-products (DBPs) are formed upon drinking water treatment when disinfectantsreact with organic matter in the water. Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) provides information on the compositions of individual DBPs in the unknown, toxicologically relevantfraction, comprising non-volatile, high-molecular weight DBPs. This review evaluates current applications of FTICR-MS for DBP analysis to assist improved analysis with this technique. Four methodological aspects are infocus, 1) The use of quenching agents, 2) The choice of extraction method 3) The choice of ionization techniques/modes, and 4) Data processing including DBP formula verification and interpretation. Quenching can lead todecomposition or adduct formation and needs to be further evaluated or avoided. There is a large potential toexpand FT-ICR-MS DBP analysis by applying different SPE sorbents and ionization techniques, and improvedsystematic verification procedures are important to ensure reliable non-target analysis.
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