| 1. |
- Bachinger, Th, et al.
(författare)
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Searching for process information in the aroma of cell cultures
- 2000
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Ingår i: Trends in Biotechnology. - 0167-7799 .- 1879-3096. ; 18:12, s. 494-500
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Tidskriftsartikel (refereegranskat)abstract
- Aroma emissions from living cells can provide valuable information about the metabolic and physiological condition of those cells. Electronic noses are chemical gas-sensor arrays that use artificial neural network models to evaluate aromas. They can interpret the complex aroma information emitted from cultures of bacteria, yeast cells and animal cells. Potential applications for electronic noses range from medical diagnosis to industrial bioprocessing. Copyright (C) 2000 Elsevier Science Ltd.
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| 2. |
- Brodelius, Peter
(författare)
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The Potential Role of Immobilization in Plant Cell Biotechnology
- 1985
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Ingår i: Trends in Biotechnology. - : Elsevier BV. - 0167-7799 .- 1879-3096. ; 3:11, s. 280-285
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Tidskriftsartikel (refereegranskat)abstract
- It has long been hoped that the unique biosynthetic capacity of plants could be exploited in vitro using culture systems analogous to microbial fermentations. However, the characteristics of both the growth and metabolism of plant cells in vitro differ considerably from those of microbial cells and plant cell suspension culture systems have met with limited success. Immobilizing the cells creates a new set of options for the plant biotechnologist to explore. Improvements in some process criteria are apparent although evaluating the potential of immobilized plant cells for producing commercial compounds will only be possible when the biological problems have been overcome.
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| 3. |
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| 4. |
- Klaus-Joerger, Tanja, et al.
(författare)
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Bacteria as workers in the living factory : metal-accumulating bacteria and their potential for materials science
- 2001
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Ingår i: Trends in Biotechnology. - : Elsevier. - 0167-7799 .- 1879-3096. ; 19:1, s. 15-20
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Forskningsöversikt (refereegranskat)abstract
- Metal micro-/nano-particles with suitable chemical modification can be organized into new ceramic–metal (cermet) or organic–metal (orgmet) composites or structured materials. These materials are attracting significant attention because of their unique structures and highly optimized properties. However, the synthesis of composite materials with inhomogeneities on the nanometer or sub-micrometer scale is a continuing challenge in materials science. Many industrial physical and chemical surface-coating processes using conventional techniques are both energy and cost inefficient and require sophisticated instrumentation. In the future, biology might offer a superior option.
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| 5. |
- Ohlson, S, et al.
(författare)
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Continuous weak-affinity immunosensing
- 2000
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Ingår i: Trends in Biotechnology. - 0167-7799 .- 1879-3096. ; 18:2, s. 49-52
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Tidskriftsartikel (refereegranskat)abstract
- A multitude of weak biological interactions, either working alone or in concert, occur frequently throughout biological systems. We have used this natural feature of readily reversible interactions as the basis for continuous immunosensing. In a model system, a set of weak monoclonal antibodies directed towards a carbohydrate epitope was studied with the aid of surface plasmon resonance. Because the system requires no regeneration, it can be used as a truly on-line immunosensing device. This principle should have wide application in all areas where there is a need for the continuous evaluation of a molecule.
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| 6. |
- Ohlson, Sten, et al.
(författare)
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High Performance Liquid Affinity Chromatography: a New Tool in Biotechnology
- 1989
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Ingår i: Trends in Biotechnology. - : Elsevier BV. - 0167-7799 .- 1879-3096. ; 7:7, s. 179-186
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Tidskriftsartikel (refereegranskat)abstract
- In high performance liquid affinity chromatography (HPLAC), the biospecificity of affinity chromatography is combined with the robust support materials of HPLC. HPLAC can provide specificity, speed and high resolution in chromatography both on analytical and preparative scales. The number of commercially available HPLAC matrices is an indicator of the growing use of the technique.
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| 7. |
- Ameur, Adam, et al.
(författare)
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Single-Molecule Sequencing : Towards Clinical Applications
- 2019
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Ingår i: Trends in Biotechnology. - : Elsevier BV. - 0167-7799 .- 1879-3096. ; 37:1, s. 72-85
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Forskningsöversikt (refereegranskat)abstract
- In the past several years, single-molecule sequencing platforms, such as those by Pacific Biosciences and Oxford Nanopore Technologies, have become available to researchers and are currently being tested for clinical applications. They offer exceptionally long reads that permit direct sequencing through regions of the genome inaccessible or difficult to analyze by short-read platforms. This includes disease-causing long repetitive elements, extreme GC content regions, and complex gene loci. Similarly, these platforms enable structural variation characterization at previously unparalleled resolution and direct detection of epigenetic marks in native DNA. Here, we review how these technologies are opening up new clinical avenues that are being applied to pathogenic microorganisms and viruses, constitutional disorders, pharmaco-genomics, cancer, and more.
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| 8. |
- Andreasson, Erik, et al.
(författare)
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Insights on cisgenic plants with durable disease resistance under the European Green Deal
- 2023
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Ingår i: Trends in Biotechnology. - 0167-7799 .- 1879-3096. ; 41, s. 1027-1040
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Forskningsöversikt (refereegranskat)abstract
- Significant shares of harvests are lost to pests and diseases, therefore, minimizing these losses could solve part of the supply constraints to feed the world. Cisgenesis is defined as the insertion of genetic material into a recipient organism from a donor that is sexually compatible. Here, we review (i) conventional plant breeding, (ii) cisgenesis, (iii) current pesticide-based disease management, (iv) potential economic implications of cultivating cisgenic crops with durable disease resistances, and (v) potential environmental implications of cultivating such crops; focusing mostly on potatoes, but also apples, with resistances to Phytophthora infestans and Venturia inaequalis, respectively. Adopting cisgenic varieties could provide benefits to farmers and to the environment through lower pesticide use, thus contributing to the European Green Deal target.
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| 9. |
- Azharuddin, Mohammad, 1986-, et al.
(författare)
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Nano toolbox in immune modulation and nanovaccines
- 2022
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Ingår i: Trends in Biotechnology. - Oxford, United Kingdom : Elsevier. - 0167-7799 .- 1879-3096. ; 40:10, s. 1195-1212
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Forskningsöversikt (refereegranskat)abstract
- Despite the great success of vaccines over two centuries, the conventional strategy is based on attenuated/altered microorganisms. However, this is not effective for all microbes and often fails to elicit a protective immune response, and sometimes poses unexpected safety risks. The expanding nano toolbox may overcome some of the roadblocks in vaccine development given the plethora of unique nanoparticle (NP)-based platforms that can successfully induce specific immune responses leading to exciting and novel solutions. Nanovaccines necessitate a thorough understanding of the immunostimulatory effect of these nanotools. We present a comprehensive description of strategies in which nanotools have been used to elicit an immune response and provide a perspective on how nanotechnology can lead to future personalized nanovaccines.
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| 10. |
- Bajhaiya, Amit K., et al.
(författare)
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Transcriptional Engineering of Microalgae : Prospects for High-Value Chemicals
- 2017
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Ingår i: Trends in Biotechnology. - : Elsevier BV. - 0167-7799 .- 1879-3096. ; 35:2, s. 95-99
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Tidskriftsartikel (refereegranskat)abstract
- Microalgae are diverse microorganisms that are of interest as novel sources of metabolites for various industrial, nutritional, and pharmaceutical applications. Recent studies have demonstrated transcriptional engineering of some metabolic pathways. We propose here that transcriptional engineering could be a viable means to manipulate the biosynthesis of specific high-value metabolic products.
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