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- Brookes, AJ
(författare)
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HGBASE--a unified human SNP database
- 2001
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Ingår i: Trends in genetics : TIG. - 0168-9525. ; 17:4, s. 229-229
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Davids, Wagied, et al.
(författare)
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Loss of gene function : Clues from expressed gene fragments in Rickettsia
- 2002
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Ingår i: Trends in Genetics. - 0168-9525 .- 1362-4555. ; 18:7, s. 331-334
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Tidskriftsartikel (refereegranskat)abstract
- Many obligate intracellular pathogens have small genomes with high fractions of pseudogenes. A recent analysis of gene expression patterns in Rickettsia conorii shows that short open reading frames inside deteriorating genes are occasionally transcribed into RNA. Here, we show that substitution frequencies at nonsynonymous sites are similar for expressed and unexpressed parts of the fragmented genes. We conclude that the observed expression is a temporary stage in the gene degradation process, suggesting that the expressed gene fragments are not functional.
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- Behm, Mikaela, et al.
(författare)
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RNA Editing : A Contributor to Neuronal Dynamics in the Mammalian Brain
- 2016
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Ingår i: Trends in Genetics. - : Elsevier BV. - 0168-9525 .- 1362-4555. ; 32:3, s. 165-175
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Forskningsöversikt (refereegranskat)abstract
- Post-transcriptional RNA modification by adenosine to inosine (A-to-I) editing expands the functional output of many important neuronally expressed genes. The mechanism provides flexibility in the proteome by expanding the variety of isoforms, and is a requisite for neuronal function. Indeed, targets for editing include key mediators of synaptic transmission with an overall significant effect on neuronal signaling. In addition, editing influences splice-site choice and miRNA targeting capacity, and thereby regulates neuronal gene expression. Editing efficiency at most of these sites increases during neuronal differentiation and brain maturation in a spatiotemporal manner. This editing-induced dynamics in the transcriptome is essential for normal brain development, and we are only beginning to understand its role in neuronal function. In this review we discuss the impact of RNA editing in the brain, with special emphasis on the physiological consequences for neuronal development and plasticity.
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