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  • Forsgren, A, et al. (författare)
  • Bacteria-immunoglobulin-lymphocyte interactions--new aspects
  • 1980
  • Ingår i: Scandinavian Journal of Infectious Diseases. Supplementum. - 0300-8878. ; Suppl 24, s. 8-112
  • Tidskriftsartikel (refereegranskat)abstract
    • Of 30 bacterial species tested 18 stimulated DNA synthesis in human blood lymphocytes. The maximum response was after 3-4 days of culture suggesting a mitogenic effect. This was confirmed by the induction of polyclonal antibody production shown by a plaque assay. Most bacterial species increased the DNA synthesis in B-enriched lymphocytes and unseparated lymphocytes but had negligible activity on T-enriched lymphocytes. Among bacteria with a mitogenic effect and ability to induce polyclonal antibody production are Staphylococcus aureus, Haemophilus influenzae, Mycobacterium tuberculosis, Neisseria gonorrhoeae, Streptococcus group A and Streptococcus pneumoniae. In an attempt to define structure (s) on the B-lymphocyte surface responsible for the lymphocyte stimulation the binding of IgD, IgM, and HLA-A, -B and HLA-D antigens to different bacterial species was investigated. A high IgD binding to N. catarrhalis and H. influenzae and a moderate binding of IgD to streptococci was found. Binding studies employing radiolabelled IgD Fab- and Fc-fragments indicated that the binding probably involves the CHl-region of the IgD molecule. Three purified radiolabelled myeloma IgM M-components were all shown to be efficiently bound to many bacteria indicating that a part of the IgM molecule other than the antigen-combining site can be involved in attachment to bacteria. Highly purified detergent-solubilized HLA-A, -B and HLA-D antigens, when separately incorporated into liposomes, were bound efficiently to two strains of N. catarrhalis and to one strain of H. influenzae weakly to one strain of E. coli, but not at all to another strain E. coli. Preliminary experiments indicate that these bacteria-immunoglobulin and bacteria-HLA-antigen interactions lead to lymphocyte stimulation.
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  • Forsgren, A., et al. (författare)
  • Effect of ciprofloxacin on human lymphocytes - Laboratory studies
  • 1989
  • Ingår i: Scandinavian Journal of Infectious Diseases, Supplement. - 0300-8878. ; 21:60, s. 39-45
  • Tidskriftsartikel (refereegranskat)abstract
    • 4-Quinolones affect mammalian cellular functions in vitro in several ways. Inhibition of cell proliferation differ widely among 4-quinolones. Ciprofloxacin is one of the most antiproliferative inhibiting cell growth with about 30% at 20 mg/l. Genotoxocity tests with 4-quinolones are probably 'false' positive due to an increased [3H]-thymidine uptake not related to DNA damage. Ciprofloxacin at 10 mg/l and up causes significant DNA strand breaks which seemingly are quickly repaired and not causing mutations or cancerogenesis. Ciprofloxacin at 5 mg/l inhibits immunoglobulin production but the growth factor interleukin 2 (IL-2) is increased by 4-quinolones at the same concentration and hyperinduced at higher concentrations. Thus the effects are very contradictory. Increased IL-2 may contribute to CNS side effects.
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  • Forsgren, M, et al. (författare)
  • Herpes simplex virus and pregnancy
  • 1996
  • Ingår i: Scandinavian journal of infectious diseases. Supplementum. - 0300-8878. ; 100, s. 14-19
  • Tidskriftsartikel (refereegranskat)
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