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Sökning: L773:0300 8886 OR L773:0036 5599 OR L773:1651 2065

  • Resultat 1-10 av 344
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1.
  • Andersson, Lennart, et al. (författare)
  • Chairmen's summary
  • 2008
  • Ingår i: Scandinavian Journal of Urology and Nephrology, Supplementum. - : Informa UK Limited. - 0300-8886 .- 1651-2537 .- 0036-5599 .- 1651-2065. ; :218, s. 7-11
  • Tidskriftsartikel (refereegranskat)
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2.
  • Montironi, Rodolfo, et al. (författare)
  • Bladder cancer : pathogenesis.
  • 2008
  • Ingår i: Scandinavian Journal of Urology and Nephrology, Supplementum. - : Informa UK Limited. - 0300-8886 .- 1651-2537 .- 0036-5599 .- 1651-2065. ; :218, s. 93-4
  • Tidskriftsartikel (refereegranskat)
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4.
  • Andersson, Karl-Erik (författare)
  • Overactive bladder--pharmacological aspects.
  • 2002
  • Ingår i: Scandinavian Journal of Urology and Nephrology, Supplementum. - : Informa UK Limited. - 0300-8886 .- 0036-5599 .- 1651-2065. ; Suppl 210:Supp 210, s. 72-81
  • Tidskriftsartikel (refereegranskat)abstract
    • The micturition reflex can be initiated by contraction or distension of detrusor smooth muscle cells, or by signals from the urothelium. It has been shown that bladder distension causes release of ATP from the urothelium and that ATP can activate P2X(3) receptors on suburothelial afferent nerve terminals to evoke a neural discharge. However, most probably the activation of afferent fibres during bladder filling involves not only ATP, but a cascade of inhibitory and stimulatory transmitters/mediators. These mechanisms may be targets for future drugs. Both in the normal and functionally disturbed bladder, muscarinic receptor stimulation produces the main part of detrusor contraction, but evidence is accumulating that in disease states, such as neurogenic bladders, outflow obstruction, idiopathic detrusor instability, interstitial cystitis, and also in the ageing bladder, a non-cholinergic activation via purinergic receptors may occur. If this component of activation is responsible not only for part of the bladder contractions, but also for the symptoms of the overactive bladder, it should be considered an important target for therapeutic interventions. Drugs blocking different P2X receptor subtypes, or counteracting bladder contraction via other mechanisms. e.g. beta(3)-adrenoceptor stimulation, may be developed for treatment of the overactive bladder.
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5.
  • Bostwick, DG, et al. (författare)
  • Epidemiology and statistical methods in prediction of patient outcome.
  • 2005
  • Ingår i: Scand J Urol Nephrol Suppl. - : Informa UK Limited. ; 39:216, s. 94-110
  • Tidskriftsartikel (refereegranskat)abstract
    • Substantial gaps exist in the data of the assessment of risk and prognosis that limit our understanding of the complex mechanisms that contribute to the greatest cancer epidemic, prostate cancer, of our time. This report was prepared by an international multidisciplinary committee of the World Health Organization to address contemporary issues of epidemiology and statistical methods in prostate cancer, including a summary of current risk assessment methods and prognostic factors. Emphasis was placed on the relative merits of each of the statistical methods available. We concluded that: An international committee should be created to guide the assessment and validation of molecular biomarkers. The goal is to achieve more precise identification of those who would benefit from treatment. Prostate cancer is a predictable disease despite its biologic heterogeneity. However, the accuracy of predicting it must be improved. We expect that more precise statistical methods will supplant the current staging system. The simplicity and intuitive ease of using the current staging system must be balanced against the serious compromise in accuracy for the individual patient. The most useful new statistical approaches will integrate molecular biomarkers with existing prognostic factors to predict conditional life expectancy (i.e. the expected remaining years of a patient's life) and take into account all-cause mortality.
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7.
  • Dillner, J, et al. (författare)
  • Etiology of squamous cell carcinoma of the penis
  • 2000
  • Ingår i: Scandinavian journal of urology and nephrology. Supplementum. - : Informa UK Limited. - 0300-8886 .- 0036-5599 .- 1651-2065. ; 34:205, s. 189-193
  • Tidskriftsartikel (refereegranskat)
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