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Sökning: L773:0301 0163

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  • Ahrén, B, et al. (författare)
  • Effects of minor increase in serum calcium on the immunoheterogeneity of parathyroid hormone in healthy subjects and in patients with primary hyperparathyroidism
  • 1995
  • Ingår i: Hormone Research. - 0301-0163. ; 43:6, s. 9-294
  • Tidskriftsartikel (refereegranskat)abstract
    • To study possible influences of a mild increase in serum-ionized calcium concentration that is seen during daily life on circulating parathyroid hormone (PTH) immunoheterogeneity, we used sequence-specific PTH assays to determine serum intact PTH, C-terminal PTH and N-terminal PTH following oral calcium (1.5 g) in healthy subjects (n = 7). This was also performed in patients with primary hyperparathyroidism (pHPT; n = 10) to see if their regulation of circulating PTH molecular forms is normal. Compared to healthy subjects, the patients were hypercalcemic (p < 0.05) and had higher levels of PTH in all three assays (p < 0.001). Following the oral calcium load, serum-ionized calcium increased by 0.08 +/- 0.03 mmol/l in the patients and by 0.07 +/- 0.03 mmol/l in the healthy subjects after 90 min, whereas serum intact PTH, C-terminal PTH and N-terminal PTH were reduced, both in the healthy subjects and in the patients. Suppression by calcium of both intact PTH and C-terminal PTH were impaired in the patients (p < 0.05 and p < 0.001), whereas suppression of N-terminal PTH was normal. Furthermore, the C/i and N/i ratios were higher at the highest calcium concentration achieved after calcium intake in the healthy subjects than in the basal state in the patients (p < 0.05), in spite of the larger degree of hypercalcemia in the latter (1.40 +/- 0.06 vs. 1.31 +/- 0.02 mmol/l; p < 0.05). Thus, (1) a minor increase in serum-ionized calcium that is seen during daily life alters the relative circulating concentrations of PTH versus its fragments; (2) the impaired sensitivity to calcium in pHPT is not evident for the suppression of N-terminal PTH, and (3) pHPT is accompanied by altered immunoheterogeneity of circulating PTH.
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  • Andersson, Björn, 1977, et al. (författare)
  • Decrease in adiponectin levels correlates to growth response in growth hormone-treated children.
  • 2009
  • Ingår i: Hormone research. - : S. Karger AG. - 1423-0046 .- 0301-0163. ; 71:4, s. 213-8
  • Tidskriftsartikel (refereegranskat)abstract
    • Adiponectin is secreted by adipose tissue and circulates in human plasma at high levels. Decreased adiponectin levels are associated with insulin resistance and obesity. The aim of this study was to investigate whether changes in serum adiponectin levels are related to the growth response, insulin levels and insulin resistance during growth hormone (GH) treatment.
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