| 1. |
- Schön, Thomas, 1973-, et al.
(författare)
-
High dose prednisolone treatment of leprosy patients undergoing reactions is associated with a rapid decrease in urinary nitric oxide metabolites and clinical improvement
- 2000
-
Ingår i: Leprosy Review. - : GN1 Genesis Network. - 0305-7518 .- 2162-8807. ; 71:3, s. 355-362
-
Tidskriftsartikel (refereegranskat)abstract
- Evidence is accumulating that nitric oxide (NO) produced by macrophages has a role in the pathogenesis of reactions in leprosy. We followed the urinary levels of the metabolites of NO [nitrite (NO 2 -) and nitrate (NO 3 -)] and the clinical response to prednisolone treatment in leprosy patients (n = 9) admitted to ALERT leprosy hospital Addis Ababa, Ethiopia, because of reversal reaction (RR) or erythema nodosum leprosum (ENL). In untreated reactional leprosy patients, the levels of urinary NO metabolites (1645 ± 454 μM, n = 9, ENL = 4, RR = 5) decreased significantly 2 weeks after high dose prednisolone treatment (1075 ± 414 μM, P < 0.05), and remained stable 4 (895 ± 385 μM, P < 0.02) and 6 weeks following treatment initiation (1048 ± 452 μM, P < 0.02). This decrease was also present when the reactional patients were subdivided according to the type of reaction (ENL, RR) and coincided with a clinical improvement. In patients showing a poor clinical response to steroids, no or minor effects on the urinary NO metabolite levels were observed. We conclude that there is a correlation between the decrease in urinary NO metabolites and a favourable clinical response after high dose prednisolone treatment of reactional leprosy patients.
|
|
| 2. |
- Schön, Thomas, 1973-, et al.
(författare)
-
Increased levels of nitric oxide metabolites in urine from leprosy patients in reversal reaction
- 1999
-
Ingår i: Leprosy Review. - : GN1 Genesis Network. - 0305-7518 .- 2162-8807. ; 70:1, s. 52-55
-
Tidskriftsartikel (refereegranskat)abstract
- We measured the metabolites of NO [nitrite (NŌ 2) and nitrate (NŌ 3)] in urine from Ethiopian patients suffering from leprosy. The urinary level of NŌ 2/NŌ 3 in a group of healthy Ethiopians was 1020 ± 471 μM (n = 22). Leprosy patients in reversal reaction had significantly higher levels of NŌ 2/NŌ 3 (1817 ± 492 μM, P < 0.001, n = 12) than both the control group and leprosy patients who were not in reversal reaction (1079 ± 446 μM, n = 12). We conclude that the reversal reaction in leprosy is associated with increased urinary levels of nitric oxide metabolites.
|
|
| 3. |
- Borg, Johan, et al.
(författare)
-
Assistive devices for people affected by leprosy: underutilised facilitators of functioning?
- 2009
-
Ingår i: Leprosy Review. - 0305-7518 .- 2162-8807. ; 80:1, s. 13-21
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: People affected by leprosy and their families face social and economic problems. The focus of interventions is often on prevention of disabilities and socioeconomic rehabilitation. The objective of this study was to explore to what extent the potential of assistive devices to facilitate activities and participation of people affected by leprosy has been utilised. DESIGN: Published literature was reviewed and the findings analysed. RESULTS: Considerable attention has been given to the protecting role of assistive devices. The focus of assistive devices facilitating functioning has been on mobility aspects of self-care and domestic life. CONCLUSIONS: The findings indicate that the potential of assistive devices to facilitate activities and participation in life areas such as work and employment is still waiting to be utilised on a broad scale.
|
|
| 4. |
- Wijk, Ulrika, et al.
(författare)
-
The concurrent validity of the Amharic version of Screening of Activity Limitation and Safety Awareness (SALSA) in persons affected by leprosy
- 2013
-
Ingår i: Leprosy Review. - : British Leprosy Relief Association (LEPRA). - 0305-7518 .- 2162-8807. ; 84:1, s. 13-22
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: Leprosy is endemic in many countries and results in activity limitations.There is a need for assessment tools to guide professionals in their evaluationand choice of intervention in order to improve conditions for leprosy-affected people.The purpose of our study was to evaluate the concurrent validity of the Amharicversion of Screening of Activity Limitation and Safety Awareness (SALSA-am) scalewith Amharic version of Disability of the Arm, Shoulder and Hand (DASH-am)questionnaire.Design: Thirty-eight individuals with nerve damage due to leprosy completed theSALSA-am and DASH-am questionnaires. Spearman’s rank correlation was used todetermine relationships between SALSA and DASH scores. Specificity, sensitivityand accuracy were calculated.Results: There was a good correlation 0·87 (P , 0·001) between SALSA-amand DASH-am scores. Sensitivity, specificity and accuracy were calculated withacceptable results.Conclusions: SALSA-am is considered a useful questionnaire for determiningactivity limitations in persons affected by leprosy, and showed good correlation withDASH-am. The concurrent validity was considered good.
|
|
