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- Quttineh, Nils-Hassan, 1979-, et al.
(författare)
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Approximating the Pareto frontier for a challenging real-world bi-objective covering problem
- 2022
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Ingår i: INFOR. Information systems and operational research. - : Taylor & Francis Inc. - 0315-5986 .- 1916-0615. ; 60:3, s. 342-358
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Tidskriftsartikel (refereegranskat)abstract
- We study a bi-objective covering problem stemming from a real-world application concerning the design of camera surveillance systems for large-scale outdoor areas. It is in this application prohibitively costly to surveil the entire area, and therefore necessary to be able to present a decision-maker with trade-offs between total cost and the portion of the area that is surveilled. The problem can be stated as a set covering problem with two objectives, describing cost and portion of covering constraints that are fulfilled. Finding the Pareto frontier for these objectives is very computationally demanding and we therefore derive a method for finding a good approximate frontier in a practically feasible computing time. The method is based on the epsilon-constraint reformulation, an established heuristic for set covering problems, and subgradient optimization.
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| 2. |
- Kastbom, Alf, et al.
(författare)
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Genetic Variants of the NLRP3 Inflammasome Are Associated with Stroke in Patients with Rheumatoid Arthritis
- 2015
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Ingår i: Journal of Rheumatology. - : The Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 42:10, s. 1740-1745
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Tidskriftsartikel (refereegranskat)abstract
- Objective. Inflammasomes are intracellular protein complexes important for the production of proinflammatory cytokines. Studies have suggested that the NLRP3 inflammasome influences both the severity of rheumatoid arthritis (RA) and development of atherosclerosis. Therefore, we investigated whether functional genetic variants related to the NLRP3 inflammasome influence the risk of cardiovascular (CV) disease (CVD) in patients with RA. Methods. The incidence of CVD was assessed in 522 patients with established RA by a retrospective survey of medical records in combination with a 6-year prospective followup. NLRP3-Q705K and CARD8-C10X genotypes were analyzed in relation to CVD by logistic regression, adjusting for traditional risk factors, antirheumatic treatment, and age at the onset of RA. Results. Carriage of the NLRP3-Q705K minor allele was associated with an increased risk of stroke/transient ischemic attack (TIA; OR 2.01, 95% CI 1.0-4.1, p = 0.05), while CARD8-C10X was not associated with any type of CV event. Patients with >= 1 variant allele in both polymorphisms had an increased risk of CVD when compared with patients without variant alleles present in both polymorphisms (adjusted OR 3.05, 95% CI 1.42-6.54, p = 0.004). Stratification showed that this risk was confined to stroke/TIA (adjusted OR 5.09, 95% CI 2.27-11.44, p < 0.0001) and not to myocardial infarction (MI)/angina pectoris (adjusted OR 1.58, 95% CI 0.67-3.73). Risk estimates were consistently higher among female patients. Conclusion. Genetic variants of the NLRP3 inflammasome influence the risk of stroke/TIA, but not of MI/angina pectoris in Swedish patients with established RA.
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