| 1. |
- Sun, H., et al.
(författare)
-
Неоадъювантная химиоиммунотерапия у пациентов раком желудка с микросателлитной нестабильностью
- 2023
-
Ingår i: Voprosy Onkologii. - 0507-3758. ; 69:2, s. 275-284
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction. Perioperative chemotherapy is the standard treatment for patients with locally advanced resectable gastric cancer. The prognostic relevance of MSI status in patients undergoing neoadjuvant chemotherapy remains unclear. Aim. To study the prognostic significance of MSI in gastric cancer patients undergoing perioperative CT. Materials and methods. The study included 173 patients with locally advanced gastric cancer who received perioperative therapy at the N.N. Blokhin National Medical Research Center of Oncology. All patients underwent PCR testing for MSI-H in 5 markers (BAT25, BAT26, NR21, NR24, NR27). Tumor regression grades (TRG) were evaluated according to the Mandard tumour regression score, including disease-free survival (DFS) and overall survival (OS). Results. 17 (9.82 %) cases presented MSI-H. High TRG was detected in 15,17 % of patients with MSS status, 0 of 12 patients with MSI who received FLOT or FOLFIRINOX and 3 of 5 patients who received immunochemotherapy. The 6-month DFS in patients with MSS was 93 % versus 58 % in MSI-H patients who received CT and 100 % in patients from the immunochemotherapy group (p = 0.034). Conclusion. Our data show that the results of modern chemotherapy are worse in MSI-H patients compared to MSS tumors. However, the addition of nivolumab to chemotherapy improved the rate of pathological complete response (pCR) to 60 % in the MSI-H group.
|
|
| 2. |
- Dorfman, M.V, et al.
(författare)
-
Questionnaire-based determination of groups at high risk for lung cancer (in Russian)
- 1990
-
Ingår i: Problems of Oncology (rus). - 0507-3758. ; 36:12, s. 1469-1473
-
Tidskriftsartikel (refereegranskat)abstract
- The factor analysis of qualitative parameters carried out in 968 patients with lung cancer helped identify certain features which may play the key role in the development and, consequently, diagnosis of various types of the disease. In workers of major industries, smoking proved a significant factor of higher incidence of lung cancer. Formation of the habit at an earlier age, its intensity and concomitant occupational hazards were found to increase the risk of cancer, particularly, in males. Mass screenings and questionnaire--based interviewing of smokers are suggested. Young age and heavy smokers should be included in groups at risk irrespective of
|
|
| 3. |
|
|
