| 1. |
- Hillström, Anna, et al.
(författare)
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Hereditary Phosphofructokinase Deficiency in Wachtelhunds
- 2011
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Ingår i: Journal Of The American Animal Hospital Association. - 0587-2871 .- 1547-3317. ; 47, s. 145-150
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Tidskriftsartikel (refereegranskat)abstract
- Hereditary phosphofructokinase (PFK) deficiency was diagnosed in two Wachtelhund dogs and suspected in three related Wachtelhund dogs with exercise intolerance, hemolytic anemia, and pigmenturia. Severe, persistent reticulocytosis in light of only mild anemia together with hemoglobinuria after strenuous exercise suggested PFK deficiency. Low erythrocyte PFK activity together with low 2,3-diphosphoglycerate concentrations and a high hemoglobin-oxygen affinity confirmed the diagnosis. The PFK deficiency is due to a single missense mutation in the muscle-type PFK M-PFK gene in English springer and American cocker spaniels, whippets, and mixed-breed dogs; however, these PFK-deficient Wachtelhunds do not have the same PFK mutation.
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| 2. |
- Tidholm, A, et al.
(författare)
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Survival and prognostic factors in 189 dogs with dilated cardiomyopathy
- 1997
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Ingår i: Journal of the American Animal Hospital Association. - : American Animal Hospital Association. - 0587-2871 .- 1547-3317. ; 33:4, s. 364-368
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Tidskriftsartikel (refereegranskat)abstract
- A survival analysis was performed using the case records of 189 dogs, including 38 breeds, with congestive heart failure caused by dilated cardiomyopathy (DCM). Overall prognosis was poor, with survival rates of 17.5% at one year and 7.5% at two years. Prognosis in the individual case of DCM proved to be difficult to predict at the time of initial examination. Only three of 27 tested independent predictors of survival were identified. The most significant predictive variables were age at onset of clinical signs, followed by dyspnea and ascites (as noted on the physical examination).
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