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Sökning: L773:0735 7044 OR L773:1939 0084

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  • Hansen, Stefan, 1953, et al. (författare)
  • Links between temperamental dimensions and brain monoamines in the rat
  • 2006
  • Ingår i: Behavioral Neuroscience. - : American Psychological Association (APA). - 0735-7044 .- 1939-0084. ; 120:1, s. 85-92
  • Tidskriftsartikel (refereegranskat)abstract
    • In 27 female Wistar rats we obtained composite scores on harm avoidance and novelty seeking, as well as 57 measures of monoamines and metabolites from 10 different brain regions. A multivariate regression method was used to discover associations between individual differences in temperament and neurochemistry. Harm avoidant subjects had low levels of striatal dopamine, and high levels of cortical norepinephrine and amygdaloid 5-hydroxyindoleacetic acid. High novelty seeking scores were linked to low levels of brainstem serotonin and dopamine, and to low levels of 5-hydroxyindoleacetic acid in amygdala and accumbens. Moreover, rats scoring high on novelty seeking had higher-than-average levels of norepinephrine in the thalamus and amygdala, and of serotonin in the amygdala.
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  • Chaibi, Ilias, et al. (författare)
  • The Role of the Anterior Cingulate Cortex in Aggression and Impulsivity
  • 2023
  • Ingår i: Behavioral Neuroscience. - : AMER PSYCHOLOGICAL ASSOC. - 0735-7044 .- 1939-0084. ; 137:3, s. 155-169
  • Tidskriftsartikel (refereegranskat)abstract
    • Aggression is a complex social behavior that evolved in the context of defending a territory, fighting for limited resources, and competing for mates and protection. Although aggression considered as a negative or undesirable emotion is an essential part of many species repertoire of social behaviors. For humans, the motivations, actions, and limits of aggressive acts are not always clear. However, uncontrolled aggression may have destructive consequences, and it develops inappropriately into violence. At the neural level, several studies demonstrated that aggression is related to cortical abnormalities, including the anterior cingulate cortex (ACC). This review summarizes the state of the literature regarding the involvement of ACC in the neurobiology of aggression and impulsivity. We will first review structural and neuroanatomical studies, including volumetric and functional investigations of aggression. Next, we will discuss the neurochemical and neuropharmacological studies of aggression related to the ACC. We will focus mainly on the gamma-aminobutyric acid/glutamate balance, as well as the serotoninergic system. Finally, we will try to integrate these results and reconcile discrepancies in the field and suggest recommendations for future studies.
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