| 1. |
- Sun, Xiao-Feng, 1959-
(författare)
-
Clinicopathological and biological features of DNA tetraploid colorectal cancers
- 2006
-
Ingår i: Cancer Journal. - : Ovid Technologies (Wolters Kluwer Health). - 0765-7846 .- 1292-8658 .- 1528-9117. ; 12:6, s. 501-506
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Most studies of colorectal cancers focus on a comparison of DNA diploid to non-diploid tumors consisting of tetraploid and aneuploid tumors. Tetraploid tumors alone have not been well studied. In the present study, clinicopathological and biological features of tetraploid colorectal cancers in contrast to those of diploid and aneuploid ones were investigated. PATIENTS AND METHODS: DNA ploidy in 278 primary colorectal adenocarcinomas was determined by flow cytometry. RESULTS: Among 278 cases, 8% of the cases were tetraploidy, 44% were aneuploidy, and 48% were diploidy. Compared to diploid tumors, tetraploid tumors were more frequent in advanced stage, high index of S-phase fraction and apoptosis, higher expression of Cox-2, c-erbB-2 and heat shock protein, but had decreased inflammatory infiltration (P < 0.05). Compared to aneuploid tumors, tetraploid tumors had a high frequency of microsatellite instability, high expression of Cox-2 and heat shock protein (P < 0.05). Unlike tetraploid tumors, aneuploid tumors had increased p53 expression but did not have microsatellite instability (P < 0.05). Tetraploidy and aneploidy predicted a worse prognosis in the subgroups of stages A-C, proximal colon, p53 negative expression and higher S-phase fraction (P < 0.05). CONCLUSIONS: DNA tetraploid tumors seem, to some extent, to exhibit distinct characteristics of clinicopathology and biology compared with aneuploid or diploid colorectal cancers. Copyright © 2006 Jones and Bartlett Publishers, Inc.
|
|
| 2. |
- Zhang, Hong, et al.
(författare)
-
Importance of FAS-1377, FAS-670 and FASL-844 Polymorphisms in Tumor Onset, Progression and Pigment Phenotypes of Swedish Patients With Melanoma : A Case-Control Analysis
- 2007
-
Ingår i: The Cancer Journal. - : Lippincott Williams & Wilkins. - 1528-9117 .- 1540-336X .- 0765-7846 .- 1292-8658. ; 13:4, s. 233-237
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Human skin melanoma at later stages usually has an extremely poor prognosis. It is of importance to search for biologic markers to identify and monitor individuals at risk for melanoma for early diagnosis and to avoid tumor progression. The FAS gene and its natural ligand (FASL) gene initiate the death signal cascade, playing a central role in the apoptotic signaling pathway and tumor growth and metastasis. PATIENTS AND METHODS: In this study, we analyzed polymorphisms in 229 patients with melanoma and 351 age- and gender-matched tumor-free individuals. Genomic DNAs were isolated from mononuclear cells in peripheral vein blood, and the polymorphisms were examined with polymerase chain reaction-restriction fragment length polymorphism techniques. Frequency in distribution of the polymorphisms was compared between the patients with melanoma and the healthy control subjects, and associations with patients' pigment phenotypes, age at diagnosis, and melanoma characteristics were analyzed. RESULTS AND CONCLUSIONS: The FAS-1377, FAS-670, and FASL-844 polymorphisms were not found to be markers of melanoma risk (P > 0.05). In patients with melanoma, frequencies of the FAS-1377, FAS-670, and FASL-844 polymorphisms were different between the patients aged <50 and > or =50 years (P < or = 0.025, P < or = 0.025, and P < or = 0.01). Moreover, the FAS-670 polymorphism correlated with tumor Breslow thickness (P < or = 0.01) and Clark level (P < or = 0.001) and was associated with tumors developing in sun-exposed locations (P < or = 0.001). FAS and FASL were not markers for melanoma risk but might be important in the development and progression of sun-induced melanoma independently of skin type.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- DILLNER, J
(författare)
-
SEROLOGY OF HUMAN PAPILLOMAVIRUS
- 1995
-
Ingår i: CANCER JOURNAL - FRANCE. - 0765-7846. ; 8:5, s. 264-269
-
Forskningsöversikt (övrigt vetenskapligt/konstnärligt)
|
|
| 7. |
- FAGERBERG, J, et al.
(författare)
-
ANTIIDIOTYPES AND CANCER
- 1995
-
Ingår i: CANCER JOURNAL - FRANCE. - 0765-7846. ; 8:4, s. 181-184
-
Forskningsöversikt (övrigt vetenskapligt/konstnärligt)
|
|
| 8. |
|
|
| 9. |
|
|
