| 1. |
|
|
| 2. |
- Abtahi, Jahan, et al.
(författare)
-
Bisphosphonate-induced osteonecrosis of the jaw in a rat model arises first after the bone has become exposed. No primary necrosis in unexposed bone
- 2012
-
Ingår i: Journal of Oral Pathology & Medicine. - : John Wiley and Sons. - 0904-2512 .- 1600-0714. ; 41:6, s. 494-499
-
Tidskriftsartikel (refereegranskat)abstract
- J Oral Pathol Med (2012) 41: 494499 Background: Bisphosphonate-related osteonecrosis of the jaw was first described to start with sterile osteocyte death, similar to osteonecrosis in other parts of the skeleton. The typical chronic osteomyelitis was thought to develop when the dead bone was exposed to the oral cavity. An alternative explanation would be that the chronic osteomyelitis is a result of a bisphosphonate-related inability of infected bony lesions to heal. We tested the hypothesis that primary osteocyte death is not necessary for the development of jaw osteonecrosis. Material and methods: Forty rats were randomly allocated to four groups of 10. All animals underwent unilateral molar extraction and received the following drug treatments: Group I, controls with no drug treatment; Group II, 200 mu g/kg per day alendronate; Groups III and IV, 200 mu g/kg per day alendronate and 1 mg/kg of dexamethasone. All rats were euthanized after 14 days. Presence of osteonecrosis was determined by clinical and histological observations for groups IIII. For group IV, osteocyte viability at the contralateral uninjured site was examined using lactate dehydrogenase histochemistry (LDH). Results: All animals in the alendronate plus dexamethasone groups developed large ONJ-like lesions. Lactate dehydrogenase staining showed viable osteocytes in the contralateral jaw with no tooth extraction. No signs of osteonecosis were seen in the other groups. Conclusion: Bisphosphonates and dexamethasone caused no osteocyte death in uninjured bone, but large ONJ-like lesions after tooth extraction. Osteonecrosis of the jaw appears to arise first after the bone has been exposed. Possibly, bisphosphonates hamper the necessary resorption of bone that has become altered because of infection.
|
|
| 3. |
- Ansell, Anna, et al.
(författare)
-
Epidermal growth factor is a biomarker for poor cetuximab response in tongue cancer cells
- 2016
-
Ingår i: Journal of Oral Pathology & Medicine. - : Wiley-Blackwell. - 0904-2512 .- 1600-0714. ; 45:1, s. 9-16
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Epidermal growth factor receptor (EGFR) is a target for treatment in tongue cancer. Here, EGFR ligands were evaluated for their potential uses as predictive biomarkers of cetuximab treatment response.Methods: In three tongue cancer cell lines the influences of epidermal growth factor (EGF), amphiregulin (AR), and epiregulin (EPR) on tumour cell proliferation and cetuximab response were evaluated by the addition of recombinant human (rh) proteins or the siRNA-mediated downregulation of endogenous ligand production.Results: EGF or AR downregulation suppressed the proliferation of all investigated cell lines. Furthermore, all cell lines displayed increased cetuximab resistance upon the addition of rhEGF, whereas EGF silencing resulted in an improved cetuximab response in one cell line.Conclusions: Our data suggest that EGF and AR are critical components of the EGFR signalling network required for full proliferative potential. Moreover, EGF is a potential predictive biomarker of poor cetuximab response and a possible treatment target.
|
|
| 4. |
- Boldrup, Linda, et al.
(författare)
-
Low potential of circulating interleukin 1 receptor antagonist as a prediction marker for squamous cell carcinoma of the head and neck
- 2021
-
Ingår i: Journal of Oral Pathology & Medicine. - : John Wiley & Sons. - 0904-2512 .- 1600-0714. ; 50:8, s. 785-794
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Circulating markers are attractive molecules for prognosis and management of cancer that allow sequential monitoring of patients during and after treatment. Based on previous protein profiling data, circulating interleukin 1 receptor antagonist (IL-1Ra) was evaluated as a potential diagnostic and prognostic marker for squamous cell carcinomas of the head and neck (SCCHN). In this study, we aimed at confirming the clinical relevance of plasma IL-1Ra in SCCHN and exploring its potential as a prediction marker for SCCHN.Methods: Plasma from 87 patients with SCCHN, control plasma from 28 healthy individuals and pre-diagnostic plasma from 44 patients with squamous cell carcinoma of the oral tongue (SCCOT) and 88 matched controls were analysed with IL-1Ra electrochemiluminescence immunoassays from mesoscale diagnostics.Results: Plasma IL-1Ra was found to be up-regulated in patients with oral tongue, gingiva and base of tongue tumours compared to healthy individuals (p < 0.01). IL-1Ra levels positively correlated with tumour size (p < 0.01) and body mass index (p = 0.013). Comparing pre-diagnostic plasma to the matched controls, similar IL1-Ra levels were seen (p = 0.05).Conclusion: The anti-inflammatory cytokine IL-1Ra could be a diagnostic marker for SCCHN, whereas its potential as a cancer prediction marker was not supported by our data.
|
|
| 5. |
- Bratel, John, 1953, et al.
(författare)
-
The frequency of different T-cell receptor V-families in oral lichen planus and lichenoid contact lesions: an immunohistochemical study.
- 1998
-
Ingår i: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. - 0904-2512. ; 27:9, s. 415-9
-
Tidskriftsartikel (refereegranskat)abstract
- Oral lichen planus (OLP) and lichenoid contact lesions (CL) are recognized as different pathological conditions of the oral mucosa. Cutaneous delayed-type hypersensitivity to mercury displayed by patients with CL but not by OLP patients supports the concept of different etiological mechanisms behind the two lesions. It is not possible to reveal this difference by histopathological assessments, and differences in clinical appearances are at present the only way to discriminate between the two conditions. It has recently been observed that T cells in OLP lesions express T-cell receptors (TCR) belonging to the Vbeta3 family in a higher frequency than expected from a random distribution, suggesting an involvement of superantigens as an etiologic factor behind this condition. In an effort to discriminate more clearly between OLP and CL, and to provide clues to the etiological mechanisms behind the two lesions, the TCR V-family distributions in the inflammatory infiltrates of OLP and CL were compared. Biopsies were taken from 10 patients with manifest OLP and 10 patients with CL. Frozen sections were incubated with antibodies against TCR Vbeta3, Valpha2 and Vbeta5a utilizing a standard immunoperoxidase technique. The frequency of Vbeta3.1 (clone 8F10) was calculated as 7%, and for Valpha2 less than 3%, and the results did not reveal any differences between OLP and CL regarding the frequencies of T-cell V-families. Thus, it was not possible to discriminate between OLP and CL by immunohistochemistry staining for different V families.
|
|
| 6. |
- Chrcanovic, Bruno, et al.
(författare)
-
Adenomatoid odontogenic tumor : an updated analysis of the cases reported in the literature
- 2019
-
Ingår i: Journal of Oral Pathology & Medicine. - : John Wiley & Sons. - 0904-2512 .- 1600-0714. ; 48:1, s. 10-16
-
Forskningsöversikt (refereegranskat)abstract
- Purpose. To review the clinical and radiographic features of the available data published on adenomatoid odontogenic tumor (AOT) with special emphasis on the comparison of its variants. Methods. An electronic search was undertaken in July/2018. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. Results. 436 publications reporting 1558 cases were included, of which 739 follicular, 247 extrafollicular, and 30 peripheral AOTs. Impacted canine is associated with follicular AOTs in almost 70% of the cases. AOTs were more prevalent in females, in the second decade of life, in maxillae, in anterior region of the jaws, and most are asymptomatic, with a considerable number of lesions presenting cortical bone perforation. Most of the lesions were treated by enucleation. Some cases of recurrence were reported in the literature, but only one was well documented. No difference was found when comparing the clinical/radiological features of the follicular, extrafollicular and peripheral variants. Conclusions. AOT variants do not show distinctive clinical radiological features. Recurrence of AOT is very rare, which justify its conservative management.
|
|
| 7. |
- Chrcanovic, Bruno, et al.
(författare)
-
Ameloblastic fibroma and ameloblastic fibrosarcoma : a systematic review
- 2018
-
Ingår i: Journal of Oral Pathology & Medicine. - : John Wiley & Sons. - 0904-2512 .- 1600-0714. ; 47:4, s. 315-325
-
Forskningsöversikt (refereegranskat)abstract
- Purpose. To integrate the available data published to date on ameloblastic fibromas (AF) and ameloblastic fibrosarcomas (AFS) into a comprehensive analysis of their clinical/radiologic features. Methods. An electronic search was undertaken in July/2017. Eligibility criteria included publications having enough clinical, radiological and histological information to confirm a definite diagnosis. Results. 244 publications (279 central AF tumours, 10 peripheral AF, 103 AFS) were included. AF and AFS differed significantly with regard to the occurrence of patients’ mean age, bone expansion, cortical bone perforation and lesion size. Recurrence rates were: central AF (19.2%), peripheral AF (12.5%), AFS (all lesions, 35%), primary (de novo) AFS (28.8%), secondary AFS (occurring after an AF, 50%). Larger lesions and older patients were more often treated by surgical resections for central AF. Segmental resection resulted in the lowest rate of recurrence for most of the lesion types. AFS treated by segmental resection had a 70.5% lower probability to recur (OR 0.295; p=0.049) than marginal resection. 21.3% of the AFS-patients died due to complications related to the lesion. Conclusions. Very long follow-up is recommended for AF lesions, due to the risk of recurrence and malignant change into AFS. Segmental resection is the most recommended therapy for AFS.
|
|
| 8. |
- Chrcanovic, Bruno, et al.
(författare)
-
Central giant cell lesion of the jaws : an updated analysis of 2270 cases reported in the literature
- 2018
-
Ingår i: Journal of Oral Pathology & Medicine. - : John Wiley & Sons. - 0904-2512 .- 1600-0714. ; 47:8, s. 731-739
-
Forskningsöversikt (refereegranskat)abstract
- Purpose. To review all available data published on central giant cell lesion (CGCL) of the jaws into a comprehensive analysis of its clinical/radiologic features, with emphasis on the predictive factors associated with its recurrence. Methods. Electronic search undertaken in 5 databases (February/2018), looking for publications reporting cases of CGCLs. Results. 365 publications were included, comprising 2270 lesions. CGCLs were more prevalent in women and in the mandible, being usually asymptomatic. Cortical bone perforation occurred in 50% of the cases. Marginal/segmental resection were more often performed in larger lesions, and drug therapy was more frequent in small lesions. Recurrence was reported in 232/1316 cases (17.6%). The recurrence rate of the aggressive lesions (22.8%) after surgical treatment was higher than non-aggressive lesions (7.8%). Four out of five CGCLs showed partial/total regression with pharmacological treatment. Aggressive lesions showed worse response to corticosteroids than non-aggressive lesions. For the lesions submitted to surgery as the first treatment, curettage, enucleation or marginal resection in relation to segmental resection, aggressive lesions, cortical bone perforation, and tooth root resorption were associated with increased recurrence rate. Recurrence related to combination of surgical/pharmacological treatment could not be evaluated due to the variety of protocols. Conclusions. Aggressive CGCLs recur more often than the non-aggressive ones. Despite sometimes showing poor response to corticosteroid injection or surgical curettage, a combination of both treatment strategies should be considered in these aggressive cases in order to reduce morbidities associated with radical surgery. The best protocol to manage aggressive and non-aggressive lesions remains to be determined.
|
|
| 9. |
- Chrcanovic, Bruno, et al.
(författare)
-
Clinical factors associated with the recurrence of central giant cell lesions.
- 2019
-
Ingår i: Journal of Oral Pathology & Medicine. - : John Wiley & Sons. - 0904-2512 .- 1600-0714. ; 48:9, s. 799-802
-
Tidskriftsartikel (refereegranskat)abstract
- Central giant cell lesion of the jaws (CGCLJ) is a destructive condition that shows a varied and unpredictable biological behaviour. In the present study, we aimed to evaluate factors associated with the recurrence of CGCLJ. Based on the data of a previous systematic review of 2,270 CGCLJ, we used the multiple imputation to deal with the missing data. The dependent variable was the recurrence after the first treatment (yes/no). The dichotomic covariates were sex, upper or lower jaw location, size (up to or larger than 4 cm), pain, cortical bone perforation (yes/no), locularity (uni-/multilocular), tooth displacement (yes/no), treatment type (curettage or enucleation) and root resorption (yes/no). The final logistic model indicated that the tumours associated with tooth displacement, root resorption, and treated with curettage had a more significant chance of recurrence. In conclusion, our study suggests that tooth displacement, root resorption, and the type of treatment are potentially useful in the future construction of an algorithm for patient's treatment. This article is protected by copyright. All rights reserved.
|
|
| 10. |
- Chrcanovic, Bruno, et al.
(författare)
-
Peripheral giant cell granuloma : an updated analysis of 2824 cases reported in the literature
- 2018
-
Ingår i: Journal of Oral Pathology & Medicine. - : John Wiley & Sons. - 0904-2512 .- 1600-0714. ; 47:5, s. 454-459
-
Forskningsöversikt (refereegranskat)abstract
- Objective. To integrate the available data published on peripheral giant cell granuloma (PGCG) into a comprehensive analysis of its clinical/radiologic features. Materials and Methods. An electronic search was undertaken in January/2018 in 5 databases, looking for publications reporting cases of PGCGs. Probability of recurrence was calculated for some variables. Results. 165 publications were included, 2824 lesions identified. PGCGs were slightly more prevalent in women and more prevalent in mandibles, usually asymptomatic, and presenting erosion of the subjacent bone in almost 1/3 of cases. Additional curettage (2.8%) or peripheral osteotomy (0%) after excision presented lower recurrence rates in comparison to excision alone (16%). Excision followed by curettage decreases the probability of recurrence by 85% in comparison to excision alone. Other factors (age, lesion size, follow-up, gender, location, clinical symptoms, bone erosion) seem to do not influence the probability of recurrence. Conclusions. As surgical excision alone shows a considerable recurrence rate, excision followed by an additional therapy - curettage or peripheral osteotomy - should be the first choice of treatment of PGCG.
|
|
