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Sökning: L773:0952 7915

  • Resultat 1-10 av 33
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  • Andersson, J, et al. (författare)
  • Immunity to infection
  • 2002
  • Ingår i: CURRENT OPINION IN IMMUNOLOGY. - 0952-7915. ; 14:4, s. 409-412
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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  • Söderhäll, Kenneth, et al. (författare)
  • Role of the prophenoloxidase-activating system in invertebrate immunity
  • 1998
  • Ingår i: Current Opinion in Immunology. - 0952-7915 .- 1879-0372. ; 10:1, s. 23-28
  • Tidskriftsartikel (refereegranskat)abstract
    • The melanization reaction, which is a common response to parasite entry in invertebrate animals, especially arthropods, is due to the activity of an oxidoreductase, phenoloxidase. This enzyme is part of a complex system of proteinases, pattern recognition
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  • Apcher, Sebastien, et al. (författare)
  • In search of the cell biology for self- versus non-self- recognition
  • 2023
  • Ingår i: Current Opinion in Immunology. - 0952-7915 .- 1879-0372. ; 83
  • Forskningsöversikt (refereegranskat)abstract
    • Several of today's cancer treatments are based on the immune system's capacity to detect and destroy cells expressing neoantigens on major histocompatibility class-I molecules (MHC-I). Despite this, we still do not know the cell biology behind how antigenic peptide substrates (APSs) for the MHC-I pathway are produced. Indeed, there are few research fields with so many divergent views as the one concerning the source of APSs. This is quite remarkable considering their fundamental role in the immune systems’ capacity to detect and destroy virus-infected or transformed cells. A better understanding of the processes generating APSs and how these are regulated will shed light on the evolution of self-recognition and provide new targets for therapeutic intervention. We discuss the search for the elusive source of MHC-I peptides and highlight the cell biology that is still missing to explain how they are synthesised and where they come from.
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  • Apcher, Sebastien, et al. (författare)
  • The source of MHC class I presented peptides and its implications
  • 2016
  • Ingår i: Current Opinion in Immunology. - : Elsevier BV. - 0952-7915 .- 1879-0372. ; 40, s. 117-122
  • Forskningsöversikt (refereegranskat)abstract
    • The source of peptides that enter the major histocompatibility class I (MHCI) pathway has been intensively debated over the last two decades. The initial assumption that peptides are derived from degradation of full length proteins was challenged by a model in which alternative translation products are a source of peptides. This model has been tested and supported by scientific data. We now need new hypotheses on the physiological implications of different sources of peptides for the MHCI pathway. The aim of this overview is to give an up-todate account of the source of antigenic peptide material for the MHCI pathway and to incorporate the more recent observations of alternative mRNA translation products into existing models of the direct and cross-presentation pathways.
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  • Resultat 1-10 av 33

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