| 1. |
- Agace, William, et al.
(författare)
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T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines
- 2000
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Ingår i: Current Opinion in Cell Biology. - 0955-0674. ; 12:5, s. 563-568
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Forskningsöversikt (refereegranskat)abstract
- The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our understanding of the interaction of the alpha(Ebeta7) integrin with its epithelial cell ligand, E-cadherin. In addition, a new adhesion molecule has been identified on non-intestinal epithelial cells, termed lymphocyte-endothelial-epithelial-cell adhesion molecule (LEEP-CAM). Finally, there have been advances in our understanding of the role of skin- or gut-epithelia-derived chemokines in regulating activated T cell homing to these sites.
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| 4. |
- ZETTERBERG, A, et al.
(författare)
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What is the restriction point?
- 1995
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Ingår i: Current opinion in cell biology. - : Elsevier BV. - 0955-0674. ; 7:6, s. 835-842
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Tidskriftsartikel (refereegranskat)
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| 5. |
- Au, Catherine E, et al.
(författare)
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Organellar proteomics to create the cell map.
- 2007
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Ingår i: Current opinion in cell biology. - : Elsevier BV. - 0955-0674. ; 19:4, s. 376-85
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Tidskriftsartikel (refereegranskat)abstract
- The elucidation of a complete, accurate, and permanent representation of the proteome of the mammalian cell may be achievable piecemeal by an organellar based approach. The small volume of organelles assures high protein concentrations. Providing isolated organelles are homogenous, this assures reliable protein characterization within the sensitivity and dynamic range limits of current mass spec based analysis. The stochastic aspect of peptide selection by tandem mass spectrometry for sequence determination by fragmentation is dealt with by multiple biological replicates as well as by prior protein separation on 1-D gels. Applications of this methodology to isolated synaptic vesicles, clathrin coated vesicles, endosomes, phagosomes, endoplasmic reticulum, and Golgi apparatus, as well as Golgi-derived COPI vesicles, have led to mechanistic insight into the identity and function of these organelles.
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| 6. |
- Bengoechea-Alonso, Maria T., et al.
(författare)
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SREBP in signal transduction : cholesterol metabolism and beyond
- 2007
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Ingår i: Current Opinion in Cell Biology. - : Elsevier BV. - 0955-0674 .- 1879-0410. ; 19:2, s. 215-222
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Tidskriftsartikel (refereegranskat)abstract
- The last few years have seen important advances in defining the mechanisms that cells use to monitor changes in cholesterol levels and regulate lipid metabolism. This work has unraveled a feedback system that enables cholesterol and certain sterol intermediates to regulate the proteolysis and transport of specific membrane proteins. The sterol regulatory element-binding protein (SREBP) family of transcription factors is at the center of this feedback system. These membrane-embedded proteins are activated by ER-to-Golgi transport followed by limited proteolysis. In addition, both the activation of the SREBPs and the stability of the rate-limiting enzyme in cholesterol synthesis are regulated by the ubiquitin-proteasome system in a sterol-dependent manner. The ubiquitin-proteasome system also regulates the degradation of active SREBPs. Recent work also highlights the important role of this regulatory system in several organisms, ranging from yeast to humans. In addition, the SREBP pathway has been found to regulate a diverse set of cellular processes, including phagocytosis, cell cycle progression, oxygen sensing and survival in response to bacterial infection. These advances illustrate the wide-ranging roles that SREBPs and membrane biogenesis have in cell biology.
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| 7. |
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| 8. |
- Dillin, Andrew, et al.
(författare)
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The good and the bad of being connected: The integrons of aging
- 2014
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Ingår i: Current Opinion in Cell Biology. - : Elsevier BV. - 0955-0674. ; 26:1, s. 107-112
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Tidskriftsartikel (refereegranskat)abstract
- Over 40 years ago, Francois Jacob proposed that levels of 'integrons' explain how biological systems are constructed. Today, these networks of interactions between tissues, cells, organelles, metabolic pathways, genes, and individual molecules provide key insights into biology. We suggest that the wiring and interdependency between subsystems within a network are useful to understand the aging process. The breakdown of one subsystem (e.g. an organelle) can have ramifications for other interconnected subsystems, leading to the sequential collapse of subsystem functions. But yet, the interconnected nature of homeostatic wiring can provide organisms with the means of compensating for the decline of one subsystem. This occurs at multiple levels in an organism. - for example, between organelles or between tissues. We review recent data that highlight the importance of such interconnectivity/communication in the aging process, in both progressive decline and longevity assurance. © 2013.
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| 9. |
- Faure, L, et al.
(författare)
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Emergence of neuron types
- 2022
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Ingår i: Current opinion in cell biology. - : Elsevier BV. - 1879-0410 .- 0955-0674. ; 79, s. 102133-
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Tidskriftsartikel (refereegranskat)
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| 10. |
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