| 1. |
- Bengoechea-Alonso, Maria T., et al.
(författare)
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SREBP in signal transduction : cholesterol metabolism and beyond
- 2007
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Ingår i: Current Opinion in Cell Biology. - : Elsevier BV. - 0955-0674 .- 1879-0410. ; 19:2, s. 215-222
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Tidskriftsartikel (refereegranskat)abstract
- The last few years have seen important advances in defining the mechanisms that cells use to monitor changes in cholesterol levels and regulate lipid metabolism. This work has unraveled a feedback system that enables cholesterol and certain sterol intermediates to regulate the proteolysis and transport of specific membrane proteins. The sterol regulatory element-binding protein (SREBP) family of transcription factors is at the center of this feedback system. These membrane-embedded proteins are activated by ER-to-Golgi transport followed by limited proteolysis. In addition, both the activation of the SREBPs and the stability of the rate-limiting enzyme in cholesterol synthesis are regulated by the ubiquitin-proteasome system in a sterol-dependent manner. The ubiquitin-proteasome system also regulates the degradation of active SREBPs. Recent work also highlights the important role of this regulatory system in several organisms, ranging from yeast to humans. In addition, the SREBP pathway has been found to regulate a diverse set of cellular processes, including phagocytosis, cell cycle progression, oxygen sensing and survival in response to bacterial infection. These advances illustrate the wide-ranging roles that SREBPs and membrane biogenesis have in cell biology.
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| 2. |
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| 3. |
- Faure, L, et al.
(författare)
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Emergence of neuron types
- 2022
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Ingår i: Current opinion in cell biology. - : Elsevier BV. - 1879-0410 .- 0955-0674. ; 79, s. 102133-
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Tidskriftsartikel (refereegranskat)
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| 4. |
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| 5. |
- Heldin, Carl-Henrik, et al.
(författare)
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Cell regulation: Cellular signaling
- 2007
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Ingår i: Current Opinion in Cell Biology. - : Elsevier Ltd.. - 0955-0674 .- 1879-0410. ; 19:2, s. 109-111
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Heldin, Carl-Henrik, et al.
(författare)
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Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition
- 2009
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Ingår i: Current Opinion in Cell Biology. - : Elsevier Ltd.. - 0955-0674 .- 1879-0410. ; 21:2, s. 166-176
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Forskningsöversikt (refereegranskat)abstract
- Members of the transforming growth factor-beta (TGF-beta) family have important roles during embryogenesis, as well as in the control of tissue homeostasis in the adult. They exert their cellular effects via binding to serine/threonine kinase receptors. Members of the Smad family of transcription factors are important intracellular messengers, and recent studies have shown that the ubiquitin ligase TRAF6 mediates other specific signals. TGF-beta signaling is tightly controlled by post-translational modifications, which regulate the activity, stability, and subcellular localization of the signaling components. The aim of this review is to summarize some of the recent findings on the mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition.
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| 7. |
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| 8. |
- Lundmark, Richard, et al.
(författare)
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The adaptable caveola coat generates a plasma membrane sensory system
- 2024
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Ingår i: Current Opinion in Cell Biology. - : Elsevier. - 0955-0674 .- 1879-0410. ; 88
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Forskningsöversikt (refereegranskat)abstract
- Caveolae are atypical plasma membrane invaginations that take part in lipid sorting and regulation of oxidative and mechanical plasma membrane stress. Caveola formation requires caveolin, cavin, and specific lipid types. The recent advances in understanding the structure and assembly of caveolin and cavin complexes within the membrane context have clarified the fundamental processes underlying caveola biogenesis. In addition, the curvature of the caveola membrane is controlled by the regulatory proteins EHD2, pacsin2, and dynamin2, which also function to restrain the scission of caveolae from the plasma membrane (PM). Here, this is integrated with novel insights on caveolae as lipid and mechanosensing complexes that can dynamically flatten or disassemble to counteract mechanical, and oxidative stress.
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| 9. |
- Ohlsson, Rolf, et al.
(författare)
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The 4C technique : the ‘Rosetta stone’ for genome biology in 3D?
- 2007
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Ingår i: Current Opinion in Cell Biology. - : Elsevier BV. - 0955-0674 .- 1879-0410. ; 19:3, s. 321-325
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Tidskriftsartikel (refereegranskat)abstract
- Despite considerable efforts, the spatial link between the nuclear architecture and the genome remains enigmatic. The 4C method, independently innovated in four different laboratories, might in combination with other methods change that. As this method is based on the unbiased identification of sequences interacting with specific baits, there are unique opportunities for unravelling the secrets of how the genome functions in 3D.
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| 10. |
- Schwartz, Yuri B, et al.
(författare)
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Polycomb complexes and epigenetic states
- 2008
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Ingår i: Current Opinion in Cell Biology. - : Elsevier BV. - 0955-0674 .- 1879-0410. ; 20:3, s. 266-273
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Tidskriftsartikel (refereegranskat)abstract
- Important advances in the study of Polycomb Group (PcG) complexes in the past two years have focused on the role of this repressive system in programing the genome. Genome-wide analyses have shown that PcG mechanisms control a large number of genes regulating many cellular functions and all developmental pathways. Current evidence shows that, contrary to the classical picture of their role, PcG complexes do not set a repressed chromatin state that is maintained throughout development but have a much more dynamic role. PcG target genes can become repressed or be reactivated or exist in intermediate states. What controls the balance between repression and derepression is a crucial question in understanding development and differentiation in higher organisms.
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