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- Holmér Pettersson, Pia, et al.
(författare)
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Early bioavailability in day surgery : A comparison between orally, rectally, and intravenously administered paracetamol
- 2005
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Ingår i: Ambulatory Surgery. - : Elsevier BV. - 0966-6532 .- 1873-2097. ; 12:1, s. 27-30
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Compare early bioavailability of rectal, effervescent oral, and i.v. paracetamol.Scope:Five groups of N = 7 patients received 1 or 2 g paracetamol orally or rectally or 1 g i.v. immediately after day surgery. Paracetamol concentrations taken after 20, 40 and 80 min. Median plasma paracetamol concentrations for 1 versus 2 g effervescents were 78 (25–114) versus 108 (95–146) μmol L−1 at 80 min and 16 (9–30) versus 17 (10–30) μmol L−1 for 1 versus 2 g suppositories. Paracetamol i.v. gave median 97 (77–135) μmol L−1 after 40 min.Conclusion: Only intravenously and 2 g effervescent paracetamol gave therapeutic concentrations during the period studied.
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