| 1. |
- Leek, Håkan, et al.
(författare)
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Pilocarpine treatment of xerostomia in head and neck patients
- 2002
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Ingår i: Micron. - 0968-4328. ; 33:2, s. 153-155
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Forskningsöversikt (refereegranskat)abstract
- We studied the effect of pilocarpine hydrochloride, a parasympathicomimewtic agent, on major salivary gland output and subjective responses in 40 patients with salivary hypofunction. Pilocarpine increased salivary output or gave significant symptomatic relief in 21 of the 40 patients. The women fared better than the men. Side effects were uncommon, were generally mild, and caused no treatment interruption. These results indicate that pilocarpine is effective in relieving the signs and symptoms of postradiation xerostomia. (C) 2001 Elsevier Science Ltd. All rights reserved.
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| 2. |
- Almqvist, Nils, et al.
(författare)
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Imaging human erythrocyte spectrin with atomic force microscopy
- 1994
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Ingår i: Micron. - : Elsevier BV. - 0968-4328 .- 1878-4291. ; 25:3, s. 227-232
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Tidskriftsartikel (refereegranskat)abstract
- Isolated spectrin covalently attached to a surface in a liquid environment as well as dried on mica has been studied with a contact-mode atomic force microscope. Both pyramidal and conical-type cantilever tip facets were used in the AFM. Our images show structures and give dimensions that correlate well with previous structural studies using transmission electron microscopy.
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| 3. |
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| 4. |
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| 5. |
- Adegoke, Olutayo, et al.
(författare)
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Scanning electron microscopy and atom probe tomography characterization of laser powder bed fusion precipitation strengthening nickel-based superalloy
- 2023
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Ingår i: Micron. - 0968-4328 .- 1878-4291. ; 171
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Tidskriftsartikel (refereegranskat)abstract
- Atom probe tomography (APT) was utilized to supplement scanning electron microscopy (SEM) characterizationof a precipitation strengthening nickel-based superalloy, Alloy 247LC, processed by laser powder bed fusion (LPBF). It was observed that the material in the as-built condition had a relatively high strength. Using both SEMand APT, it was concluded that the high strength was not attributed to the typical precipitation strengtheningeffect of γ’. In the absence of γ’ it could be reasonably inferred that the numerous black dots observed in thecells/grains with SEM were dislocations and as such should be contributing significantly to the strengthening.Thus, the current investigation demonstrated that relatively high strengthening can be attained in L-PBF even inthe absence of precipitated γ’. Even though γ’ was not precipitated, the APT analysis displayed a nanometer scalepartitioning of Cr that could be contributing to the strengthening. After heat-treatment, γ’ was precipitated and itdemonstrated the expected high strengthening behavior. Al, Ta and Ti partitioned to γ’. The strong partitioningof Ta in γ’ is indicative that the element, together with Al and Ti, was contributing to the strain-age crackingoccurring during heat-treatment. Cr, Mo and Co partitioned to the matrix γ phase. Hf, Ta, Ti and W were found inthe carbides corroborating previous reports that they are MC.
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| 6. |
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| 7. |
- Blomgren, Bo, et al.
(författare)
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A computerised, unbiased method for epithelial measurement
- 2004
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Ingår i: Micron. - Amsterdam : Elsevier. - 0968-4328 .- 1878-4291. ; 35, s. 319-329
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveTo develop and evaluate a standardised method for unbiased measurements of epithelial thickness taking the variability of the dermal papillae in consideration.MethodsA computer-assisted measurement program suitable for haematoxylin and eosin routine stained specimens has been developed.ResultsThe developed program was designed to measure four different distance parameters, taking the number, height and width of dermal papillae into account. The measurement program gave very accurate results compared with manual measurements. The measurement results can be presented as tables or star graphs, and the results can be further processed by multivariate analysis.ConclusionThe computer-assisted measurement program is considered to be a valuable and reliable tool for measurements of epithelial thickness, irrespectively of the variability of the epithelial morphology. Since length, size and number of the papillae may change with certain pathological conditions, age and also under hormonal influence, this method can be a helpful diagnostic tool.
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| 8. |
- Blomgren, Bo, et al.
(författare)
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A novel method for quantification of the folding of elastic laminae in elastic arteries
- 2008
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Ingår i: Micron. - : Elsevier BV. - 0968-4328 .- 1878-4291. ; 39:5, s. 623-630
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Forskningsöversikt (refereegranskat)abstract
- A transgenic mouse overexpressing the human form of semicarbazide-sensitive amine oxidase (SSAO) is known to have an abnormal structure of the elastic laminae and the elastic fibres in the aorta. Compared to the non-transgenic littermates, the elastic laminae are less folded. In order to quantify the undulation of this structure, an image analysis program that identified the elastic laminae was developed. The program measures the area fraction in different sectors from a plane parallel to the aorta wall. Images were taken from unstained aorta specimens where the elastic laminae were visualised with phase contrast microscopy. A contextual operation of the images produced a local orientation estimation for every linear structure. The image was then thresholded in eight sectors from 0 degrees to 180 degrees, with different orientation angles. The results show that the area fraction of the elastic laminae was significantly lower for the transgenic mouse in all sectors measured except for two. At 0-25 degrees, no difference was seen. In the sector at 160-180 degrees, parallel to the aorta wall, the area fraction of elastic laminae was instead significantly higher in the transgenic mouse. A novel method is presented, developed for detection and quantification of pathological changes in the elastic laminae in the aorta wall. The method gave reliable results and is considered to be a useful tool for morphometric studies of aorta with this kind of altered morphology concerning the elastic laminae. When compared with tangent count, the control group had a significantly larger mean curvature.
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| 9. |
- Canovic, Sead, et al.
(författare)
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CVD TiC/alumina multilayer coatings grown on sapphire single crystals
- 2011
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Ingår i: Micron. - : Elsevier BV. - 0968-4328 .- 1878-4291. ; 42:8, s. 808-818
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Tidskriftsartikel (refereegranskat)abstract
- Multilayers of TiC/α-Al(2)O(3) consisting of three (1μm thick) alumina layers separated by thin (∼10nm) oxidized TiC layers have been deposited onto c-, a- and r-surfaces of single crystals of α-Al(2)O(3) by chemical vapour deposition (CVD). The aim of this paper is to describe and compare the detailed microstructure of the different multilayer coatings by using transmission electron microscopy (TEM). The general microstructure of the alumina layers is very different when deposited onto different surfaces of α-Al(2)O(3) single crystal substrates. On the c- and a-surfaces the alumina layers grow evenly resulting in growth of single crystal layers of TiC and alumina throughout the coating. However, when deposited on the r-surface the alumina layers generally grow unevenly. No pores are observed within the alumina layers, while a small number of pores are found at the interfaces below the TiC layers. The TiC and alumina layers grow epitaxially on the c- and a-surface substrates. On the r-surface, epitaxy is present only at some rare locations. The TiC layers were oxidized in situ for 2min in CO(2)/H(2) prior to the alumina layer deposition. For all three samples chemical analyses show that the whole TiC layer is oxidized. On the c- and a-surfaces the TiC layer was oxidized to an fcc TiCO phase. On the r-surface the oxidation stage resulted in a transformation of the initially deposited fcc TiC to a monoclinic TiCO phase, which appears to be a modified TiO structure with a high carbon content.
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| 10. |
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