| 1. |
- Ferencz, Beata, et al.
(författare)
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Genetics and Underlying Pathology of Dementia
- 2015
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Ingår i: Neuropsychology Review. - : Springer Science and Business Media LLC. - 1040-7308 .- 1573-6660. ; 25:1, s. 113-124
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Forskningsöversikt (refereegranskat)abstract
- As the population steadily ages, dementia, in all its forms, remains a great societal challenge. Yet, our knowledge of their etiology remains rather limited. To this end, genetic studies can give us insight into the underlying mechanisms that lead to the development of dementia, potentially facilitating treatments in the future. In this review we cover the most recent genetic risk factors associated with the onset of the four most common dementia types today, including Alzheimer's disease (AD), Vascular Dementia (VaD), Frontotemporal Lobar Degeneration (FTLD) and Lewy Body Dementia (LBD). Moreover, we discuss the overlap in major underlying pathologies of dementia derived from their genetic associations. While all four dementia types appear to involve genes associated with tau-pathology and neuroinflammation only LBD, AD and VaD appear to involve amyloid genes while LBD and FTLD share alpha synuclein genes. Together these findings suggest that some of the dementias may exist along a spectrum and demonstrates the necessity to conduct large-scale studies pinpointing the etiology of the dementias and potential gene and environment interactions that may influence their development.
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| 2. |
- Malmberg Gavelin, Hanna, 1982-, et al.
(författare)
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Cognition-Oriented Treatments for Older Adults : a Systematic Overview of Systematic Reviews
- 2020
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Ingår i: Neuropsychology Review. - : Springer. - 1040-7308 .- 1573-6660. ; 30:2, s. 167-193
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Forskningsöversikt (refereegranskat)abstract
- Cognition-oriented treatments - commonly categorized as cognitive training, cognitive rehabilitation and cognitive stimulation - are promising approaches for the prevention of cognitive and functional decline in older adults. We conducted a systematic overview of meta-analyses investigating the efficacy of cognition-oriented treatments on cognitive and non-cognitive outcomes in older adults with or without cognitive impairment. Review quality was assessed by A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR). We identified 51 eligible reviews, 46 of which were included in the quantitative synthesis. The confidence ratings were "moderate" for 9 (20%), "low" for 13 (28%) and "critically low" for 24 (52%) of the 46 reviews. While most reviews provided pooled effect estimates for objective cognition, non-cognitive outcomes of potential relevance were more sparsely reported. The mean effect estimate on cognition was small for cognitive training in healthy older adults (mean Hedges' g = 0.32, range 0.13-0.64, 19 reviews), mild cognitive impairment (mean Hedges' g = 0.40, range 0.32-0.60, five reviews), and dementia (mean Hedges' g = 0.38, range 0.09-1.16, seven reviews), and small for cognitive stimulation in dementia (mean Hedges' g = 0.36, range 0.26-0.44, five reviews). Meta-regression revealed that higher AMSTAR score was associated with larger effect estimates for cognitive outcomes. The available evidence supports the efficacy of cognition-oriented treatments improving cognitive performance in older adults. The extent to which such effects are of clinical value remains unclear, due to the scarcity of high-quality evidence and heterogeneity in reported findings. An important avenue for future trials is to include relevant non-cognitive outcomes in a more consistent way and, for meta-analyses in the field, there is a need for better adherence to methodological standards. PROSPERO registration number: CRD42018084490.
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| 3. |
- Papenberg, Goran, et al.
(författare)
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Genetics and Functional Imaging : Effects of APOE, BDNF, COMT, and KIBRA in Aging
- 2015
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Ingår i: Neuropsychology Review. - : Springer. - 1040-7308 .- 1573-6660. ; 25:1, s. 47-62
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Forskningsöversikt (refereegranskat)abstract
- Increasing evidence from cross-sectional and longitudinal molecular-genetic studies suggests that effects of common genetic variations on cognitive functioning increase with aging. We review the influence of candidate genes on brain functioning in old age, focusing on four genetic variations that have been extensively investigated: APOE, BDNF, COMT, and KIBRA. Similar to the behavioral evidence, there are reports from age-comparative studies documenting stronger genetic effects on measures of brain functioning in older adults compared to younger adults. This pattern suggests disproportionate impairments of neural processing among older individuals carrying disadvantageous genotypes. We discuss various factors, including gene-gene interactions, study population characteristics, lifestyle factors, and diseases, that need to be considered in future studies and may help understand inconsistent findings in the extant literature.
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| 4. |
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| 5. |
- Rieckmann, Anna, et al.
(författare)
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Implicit learning in aging : extant patterns and new directions.
- 2009
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Ingår i: Neuropsychology Review. - : Springer Science and Business Media LLC. - 1040-7308 .- 1573-6660. ; 19:4, s. 490-503
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Tidskriftsartikel (refereegranskat)abstract
- Research suggests that the striatum plays an important role in implicit learning (IL). The striatum exhibits marked age-related morphological and neurochemical losses. Yet, behavioral studies suggest that IL is generally well preserved in old age, and that age-related differences emerge only when highly complex IL tasks are used. In this review, we integrate behavioral and neuroimaging evidence on IL in aging. We suggest that relative stability of IL in old age may reflect neural reorganization that compensates for age-related losses in striatal functions. Specifically, there may be an age-related increase in reliance on extrastriatal regions (e.g., medial-temporal, frontal) during IL. This reorganization of function may be beneficial under less taxing performance conditions, but not when task demands become more challenging.
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| 6. |
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| 7. |
- Sabates, Julieta, et al.
(författare)
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The associations between neuropsychiatric symptoms and cognition in people with dementia : a systematic review and meta-analysis
- 2024
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Ingår i: Neuropsychology Review. - : Springer. - 1040-7308 .- 1573-6660. ; 34:2, s. 581-597
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Forskningsöversikt (refereegranskat)abstract
- Most people with dementia experience neuropsychiatric symptoms (NPS), including anxiety, depression or disinhibition. There is growing interest in the relationship between NPS and cognitive impairment, but data is still limited. This study aimed to investigate the specific associations between NPS and cognition in people with dementia. MEDLINE, EMBASE and PsycINFO were searched for published, peer-reviewed studies of associations between at least one NPS and one cognitive ability in people with dementia. The quality of the studies was assessed with the NIH National Heart, Lung and Blood Institute’s quality assessment tools. A meta-analysis was conducted using Robumeta package for R. Ninety studies were included. We found significant associations between NPS, global cognition and cognitive domains, e.g. apathy was associated with global cognitive and memory impairment; dysphoria was associated with worse attention; delusions with executive dysfunction. Increased NPS in people with dementia are associated with worse cognitive performance. There were few studies looking at associations between some neuropsychiatric clusters and cognitive abilities, and there was little research on causal relationships. Our review was limited by the inclusion of studies that reported associations in specific formats, and most included people with a diagnosis of Alzheimer’s disease (AD). However, given the large number of studies, this is unlikely to have biased results. More research is needed that includes diverse people with different dementia syndromes.
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| 8. |
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| 9. |
- Johansson, Mattias, 1972-, et al.
(författare)
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Acute effects of qigong exercise on mood and anxiety
- 2008
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Ingår i: International Journal of Stress Management. - : American Psychological Association (APA). - 1072-5245 .- 1573-3424. ; 15:2, s. 199-207
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Tidskriftsartikel (refereegranskat)abstract
- Psychosocial stress may lead to increased rates of anxiety and depression. Aerobic exercise and mind-body therapies are frequently described as having positive effects on psychological well-being by enhancing mood and reducing anxiety. Few studies, however, have investigated the acute psychological effects of qigong exercise. Fifty-nine regular qigong exercisers (mean age 50.8 years) were randomized to a Qigong or Control group. Pre- and postmeasurements were then compared. POMS-Depression, Anger, and Fatigue, and STAI-State Anxiety scores decreased significantly in the Qigong group but not in the Control group. Results thereby suggest that qigong exercise can produce desirable psychological effects, and Qigong exercise may therefore be included among other activities performed to boost resistance to daily stressors.
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| 10. |
- Howlin, Jillian, et al.
(författare)
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Pubertal mammary gland development: Insights from mouse models
- 2006
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Ingår i: Journal of Mammary Gland Biology and Neoplasia. - : Springer Science and Business Media LLC. - 1083-3021 .- 1573-7039. ; 11:3-4, s. 283-297
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Forskningsöversikt (refereegranskat)abstract
- During puberty the mammary gland develops from a rudimentary tree to a branched epithelial network of ducts which can support alveolar development and subsequent milk production during pregnancy and lactation. This process involves growth, proliferation, migration, branching, invasion, apoptosis and above all, tight regulation which allows these processes to take place simultaneously during the course of just a few weeks to create an adult gland. The process is under hormonal control and is thus coordinated with reproductive development. Mouse models, with overexpressed or knocked-out genes, have highlighted a number of pubertal mammary gland phenotypes and given significant insight into the regulatory mechanisms controlling this period of development. Here we review the published findings of the wide range of gene-manipulated mammary mouse models, documenting the common pubertal mammary gland phenotypes observed, and summarizing their contribution to our current understanding of how pubertal mammary gland development occurs.
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