| 1. |
- Doughty, Elizabeth S., et al.
(författare)
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Long-Term Effect of TBX4 Germline Mutation on Pulmonary Clinico-Histopathologic Phenotype
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Ingår i: Pediatric and Developmental Pathology. - 1093-5266.
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Tidskriftsartikel (refereegranskat)abstract
- Tbx4 protein, expressed in mesenchyme of the developing lung, contributes to airway branching and distal lung growth. An association between pediatric onset of pulmonary arterial hypertension (PAH) and genetic variations coding for the T-box transcription factor 4 gene (TBX4) has been increasingly recognized. Tbx4-related PAH onset has a bimodal age distribution, including severe to lethal PAH in newborns and later onset PAH. We present an autopsy study of a 24-year-old male with a heterozygous TBX4 variant, who developed pulmonary arterial hypertension at age 12 years. This unique case highlights the complex pulmonary histopathology leading to lethal cardiopulmonary failure in the setting of TBX4 mutation.
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| 2. |
- Grottling, Emma, et al.
(författare)
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Changes in the Prevalence of Embryologic Remnants in Umbilical Cord With Gestational Age
- 2019
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Ingår i: Pediatric and Developmental Pathology. - : SAGE Publications. - 1093-5266 .- 1615-5742. ; 22:4, s. 288-291
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to examine the prevalence of embryologic remnants in umbilical cords of different gestational ages. Sections from 392 umbilical cords were examined using light microscopy. Of these, 52% contained at least 1 remnant, most commonly of the allantoic duct type. Although there was a significant decrease in vitelline duct remnants over increasing gestational age, from 11% at weeks 11–25 to 1.6% at weeks 36–42 (P =.009; χ2 test), the allantoic duct remnants remained constant in prevalence irrespective of gestational age.
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| 3. |
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| 4. |
- Nozohoor Ekmark, Ann, et al.
(författare)
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The Cellular Architectures of Hypospadias
- 2020
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Ingår i: Pediatric and Developmental Pathology. - : SAGE Publications. - 1093-5266 .- 1615-5742. ; 23:6, s. 476-478
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Tidskriftsartikel (refereegranskat)
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| 5. |
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| 6. |
- Sirotkina, M, et al.
(författare)
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Genetic Analysis of Copy Number Variation in Large Chorangiomas
- 2019
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Ingår i: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. - : SAGE Publications. - 1615-5742. ; 22:3, s. 236-242
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Tidskriftsartikel (refereegranskat)abstract
- Chorangioma (CA) is the most common nontrophoblastic, vascular tumor-like lesion of the placenta with a reported incidence of 0.5% to 1% in all examined placentas. The underlying molecular mechanisms of CAs are still poorly elucidated, and a systematic investigation of the genetic background of CAs has not previously been done. Materials and Methods Tissue biopsies from 8 large (>40 mm) histologically confirmed CAs and 8 unaffected matched placenta controls, along with standard control DNA samples were analyzed for large genomic deletions and duplications using array comparative genomic hybridization (array-CGH) method. Results Array-CGH analysis revealed no rare or novel copy number variants in the CA samples compared with either standard control DNA or unaffected placenta DNA from the same individual. Discussion In this study, a systematic genetic investigation of 8 large CAs failed to demonstrate any large-scale pathogenic genetic changes. This lack of association might support a nongenetic, nontumorous origin of these lesions; however, additional genetic studies focusing on smaller genomic alterations are required to fully assess any possible genetic contribution.
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| 7. |
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| 8. |
- van der Kamp, Ananda, et al.
(författare)
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Artificial Intelligence in Pediatric Pathology: The Extinction of a Medical Profession or the Key to a Bright Future?
- 2022
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Ingår i: Pediatric and Developmental Pathology. - : SAGE PUBLICATIONS INC. - 1093-5266 .- 1615-5742. ; 25:4, s. 380-387
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Forskningsöversikt (refereegranskat)abstract
- Artificial Intelligence (AI) has become of increasing interest over the past decade. While digital image analysis (DIA) is already being used in radiology, it is still in its infancy in pathology. One of the reasons is that large-scale digitization of glass slides has only recently become available. With the advent of digital slide scanners, that digitize glass slides into whole slide images, many labs are now in a transition phase towards digital pathology. However, only few departments worldwide are currently fully digital. Digital pathology provides the ability to annotate large datasets and train computers to develop and validate robust algorithms, similar to radiology. In this opinionated overview, we will give a brief introduction into AI in pathology, discuss the potential positive and negative implications and speculate about the future role of AI in the field of pediatric pathology.
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| 9. |
- Vinnars, Marie-Therese N., et al.
(författare)
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The Number of CD68+ (Hofbauer) Cells is Decreased in Placentas with Chorioamnionitis and with Advancing Gestational Age
- 2010
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Ingår i: Pediatric and Developmental Pathology. - : Sage Publications. - 1093-5266 .- 1615-5742. ; 13:4, s. 300-304
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Tidskriftsartikel (refereegranskat)abstract
- Hofbauer cells are placental macrophages found in chorionic villous stroma; they express classic monocyte/macrophage markers, such as CD68. Little is known about their participation in placental disease and immunologic interactions at the placental interface. The aim of this study was to quantify the amount of Hofbauer cells in placentas complicated, or not, by chorioamnionitis and in placentas from different gestational ages. Fifty-eight 2nd-and 3rd-trimester placentas with the histologic diagnosis of acute chorioamnionitis were compared with 42 control placentas matched according to gestational age. Immunohistochemistry evaluation was performed with a monoclonal anti-CD68 antibody. Five areas of each placenta were photographed and 5 investigators, with the help of a computerized image analysis program, independently evaluated the number of CD68+ cells. Our results showed that there are significantly fewer CD68+ cells per villous area in placentas diagnosed with chorioamnionitis than in those of controls (P < 0.001). Moreover, there was a significant overall decrease in the number of these cells in 3rd as compared with 2nd trimester placentas (P = 0.02), as well as in placentas from term as compared to preterm pregnancies (P = 0.004). Our data indicate that CD68+ Hofbauer cells may be involved in placental infection and possibly associated with the developmental maturation of the fetoplacental unit.
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| 10. |
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