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  • Bernink, JH, et al. (författare)
  • Human ILC1: To Be or Not to Be
  • 2017
  • Ingår i: Immunity. - : Elsevier BV. - 1097-4180 .- 1074-7613. ; 46:5, s. 756-757
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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10.
  • Biram, Adi, et al. (författare)
  • Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation.
  • 2022
  • Ingår i: Immunity. - : Elsevier BV. - 1097-4180 .- 1074-7613. ; 55:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Consecutive exposures to different pathogens are highly prevalent and often alter the host immune response. However, it remains unknown how a secondary bacterial infection affects an ongoing adaptive immune response elicited against primary invading pathogens. We demonstrated that recruitment of Sca-1+ monocytes into lymphoid organs during Salmonella Typhimurium (STm) infection disrupted pre-existing germinal center (GC) reactions. GC responses induced by influenza, plasmodium, or commensals deteriorated following STm infection. GC disruption was independent of the direct bacterial interactions with B cells and instead was induced through recruitment of CCR2-dependent Sca-1+ monocytes into the lymphoid organs. GC collapse was associated with impaired cellular respiration and was dependent on TNFα and IFNγ, the latter of which was essential for Sca-1+ monocyte differentiation. Monocyte recruitment and GC disruption also occurred during LPS-supplemented vaccination and Listeria monocytogenes infection. Thus, systemic activation of the innate immune response upon severe bacterial infection is induced at the expense of antibody-mediated immunity.
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