| 1. |
- Gunnarsson, Tove, 1956-, et al.
(författare)
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Cholecystokinin peptides in cerebrospinal fluid : a pilot study in hypothyroid patients
- 1999
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Ingår i: Human Psychopharmacology. - 0885-6222 .- 1099-1077. ; 14:2, s. 113-117
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Tidskriftsartikel (refereegranskat)abstract
- The cholecystokinin tetrapeptide (CCK-4) and the sulphated octapeptide (CCK-8) were measured in cerebrospinal fluid obtained from nine hypothyroid patients before and during L-thyroxine treatment. Before treatment, CCK-4 and CCK-8S correlated negatively with S-TSH, whereas CCK-8S also showed a positive correlation with S-T3. During treatment, S-T4 correlated negatively with CCK-8S. CSF collection time was significantly shorter during treatment than prior to treatment for the first (0–6 ml) CSF fraction. On taking CSF collection time into account, the levels of both CCK-4 and CCK-8S in the first CSF fraction were significantly increased during medication. Our results are consistent with an impact of the hypothyroid disorder and L-thyroxine treatment on the disposition of CCK compounds in CSF. This might be due to an altered CSF circulation, but other mechanisms (e.g. metabolism or elimination) cannot be ruled out.
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| 2. |
- Lindgren, Magnus, et al.
(författare)
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Directed forgetting, event-related potentials and nicotine
- 1999
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Ingår i: Human Psychopharmacology. - 0885-6222 .- 1099-1077. ; 14, s. 19-29
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Tidskriftsartikel (refereegranskat)abstract
- Fifteen male users of oral snuff performed a directed forgetting task after over-night abstinence and after administration of oral snuff. Directed forgetting tasks use cues to classify items for differential reporting at test, emphasising the need for strategic encoding. Recognition was better after nicotine administration, but we found no evidence for greater strategic control, as hypothetically reflected in successful compliance with the directed forgetting instructions. Reaction time decreased after nicotine administration. Performance among fifteen controls was unaffected over two sessions.
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| 3. |
- Lindgren, Magnus, et al.
(författare)
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Effects of nicotine in visual attention tasks
- 1996
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Ingår i: Human Psychopharmacology. - 0885-6222 .- 1099-1077. ; 11, s. 47-51
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Tidskriftsartikel (refereegranskat)abstract
- Thirty-five male volunteers (18 nicotine-users and 17 controls) participated in an experiment where a flanker task and a search task were used. It was hypothesized that if nicotine affects selective attention, effects of distracting flanker stimuli should be diminished, and effects of allocation strategies in the search task should be more marked. Nicotine-users performed the tasks after an over-night abstinence, and after administration of oral snuff. In both tasks nicotine users improved more than controls, but there was no indication of nicotine effects on selective attention in either task. Our results point towards a non-specific arousing effect of nicotine.
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| 4. |
- Allgulander, Christer, et al.
(författare)
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Efficacy of venlafaxine ER in patients with social anxiety disorder : A double-blind, placebo-controlled, parallel-group comparison with paroxetine
- 2004
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Ingår i: Human Psychopharmacology. - : Wiley. - 0885-6222 .- 1099-1077. ; 19:6, s. 387-396
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Tidskriftsartikel (refereegranskat)abstract
- This study evaluated the anxiolytic efficacy, safety and tolerability of a flexible dose of venlafaxine extended release (ER) compared with placebo and paroxetine in the short-term treatment of generalized social anxiety disorder (SAD). Adult outpatients with generalized SAD (n=434) were randomized to receive capsules of venlafaxine ER 75 mg to 225 mg/day, paroxetine 20 mg to 50 mg/day, or placebo for 12 weeks. The primary efficacy variable was the Liebowitz social anxiety scale total score. Secondary efficacy variables included the patient-rated social phobia inventory and the proportion of responders in each group (a responder was defined as having a clinical global impression-improvement score of 1 or 2). Treatment with venlafaxine ER was associated with significantly greater improvement than treatment with placebo for all primary and secondary efficacy variables (p<0.05). No significant differences in primary or secondary efficacy variables were observed between the venlafaxine ER and paroxetine groups. The week 12 response rates were 69%, 66% and 36% for the venlafaxine ER, paroxetine and placebo groups, respectively. Both active treatments were generally well tolerated and were associated with a similar incidence of adverse events. This study shows that venlafaxine ER is an effective, safe and well-tolerated drug treatment for SAD.
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| 7. |
- Dzamashvili-Fogelström, Nina, et al.
(författare)
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The Impact of Agile Principles on Market-Driven Software Product Development
- 2010
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Ingår i: Software Process. - : interscience.wiley. - 1077-4866 .- 1099-1670. ; 22:1, s. 53-80
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Tidskriftsartikel (refereegranskat)abstract
- Agile development methods such as XP, SCRUM, Lean Software Development and others have gained much popularity during the last years. Agile methodologies promise faster time-to-market, satisfied customers and high quality software. While these prospects are appealing, the suitability of agile practices to different domains and business contexts still remains unclear. In this paper we investigate the applicability of agile principles in the context of market-driven software product development (MDPD), focusing on pre-project activities. This paper presents results of a comparison between typical properties of agile methods to the needs of MDPD, as well as findings of a case study conducted at Ericsson, an early adopter of agile product development. The results show misalignment between the agile principles and needs of pre-project activities in market-driven development. This misalignment threatens to subtract from the positive aspects of agile development, but maybe more importantly, threaten the overall product development by disabling effective product management.
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| 8. |
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| 9. |
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| 10. |
- Göransson, Bengt, et al.
(författare)
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The Usability Design Process : Integrating User-Centered Systems Design in the Software Development Process
- 2003
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Ingår i: Software Process Improvement and Practice: Special Issue on Bridging the Process and Practice Gaps Between Software Engineering and Human Computer Interaction. - : Wiley. ; 8:2, s. 111-131
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Tidskriftsartikel (refereegranskat)abstract
- This article reviews current efforts in bridging the gaps between software engineering and Human-Computer Interaction (HCI) and describes some critical issues that must be resolved in order to reconcile some of the differences between the two fields. We argue that user-centered systems design (UCSD) must be tightly integrated in the software development process and suggest the usability design process as a way of doing this. The usability design process is a UCSD approach for developing usable interactive systems, combining usability engineering with interaction design, and emphasizing extensive active user involvement throughout the iterative process. We outline the usability design process and illustrate the steps in the process with examples from real-life design cases. Finally, we provide an example of how the usability design process can be implemented in a commercial software-development process, Rational Unified ProcessTM (RUP).
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