| 1. |
- Afshangian, Fazlallah, et al.
(författare)
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Coprolalia in aphasic patients with stroke : a longitudinal observation from the BLAS2T database
- 2017
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Ingår i: Neurocase. - : Informa UK Limited. - 1355-4794 .- 1465-3656. ; 23:5-6, s. 249-262
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Tidskriftsartikel (refereegranskat)abstract
- The BLAS2T (bilingual aphasia in stroke-study team) initiative has been a multi-center attempt to investigate longitudinal changes in language function in a cohort of stroke subjects. This report discusses linguistic performance in four cases from the BLAS2T database who demonstrated coprolalia as an irresistible urge to say obscene words. Coprolalia was found to partly resolve in a 30-day follow-up in three cases. Recognition of coprolalia and language recovery patterns in bilingual aphasic patients with stroke would potentially lead to their even better individualized care and neurolinguistic/cognitive rehabilitation.
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| 2. |
- Almkvist, Ove, et al.
(författare)
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Degree of abnormality is associated with rate of change in measures of beta-amyloid, glucose metabolism and cognition in an autopsy-verified Alzheimer’s disease case
- 2015
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Ingår i: Neurocase. - : Informa UK Limited. - 1355-4794 .- 1465-3656. ; 21:6, s. 738-747
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Tidskriftsartikel (refereegranskat)abstract
- The degree of abnormality and rate of change in cognitive functions, positron emission tomography Pittsburg compound B (PET PIB), and fluorodeoxyglucose (FDG) measures were studied for 8 years in an autopsy-confirmed Alzheimer’s disease (AD) patient, who died 61 years old (Mini-Mental State Examination (MMSE) score 7). At first encounter with medical care, the patient was very mildly demented (MMSE score 27). She had four cognitive assessments and two examinations with PET PIB and FDG in 23 bilateral brain regions. The onset of cognitive decline was retrospectively estimated to have started in the early forties. The degree of impairment was inversely related to the rate of decline. A similar relationship was seen between the rate of change and the level of abnormality in both PIB and FDG. To conclude, rate of change in cognition, PIB, and FDG was associated with the degree of abnormality.
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| 3. |
- Ehlers, Stephan, et al.
(författare)
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Mental Impairment and Attention Deficit Hyperactivity Disorder in a Family with FRAXF
- 1999
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Ingår i: Neurocase. - : Informa UK Limited. - 1355-4794 .- 1465-3656. ; 5:6, s. 533-536
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Tidskriftsartikel (refereegranskat)abstract
- A mother and her three children with fragile X syndrome (FRAXF fragile site), shown by cytogenetic and molecular genetic methods, were neuro psychiatrically and psychometrically evaluated. All individuals exhibited clear learning disability, as well as attention deficit hyperactivity disorder. The findings suggest that these clinical attributes, particularly mental impairment, may be a phenotypic expression of the FRAXF fragility.
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| 4. |
- Ek, Lena, 1961-, et al.
(författare)
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Early cognitive impairment in a subset of patients with presumed low-grade glioma
- 2010
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Ingår i: Neurocase. - : Informa UK Limited. - 1355-4794 .- 1465-3656. ; 16:6, s. 503-511
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Tidskriftsartikel (refereegranskat)abstract
- We investigated the presence of cognitive impairment, in adults with presumed low-grade glioma at early stage of disease prior to major treatments, in relation to neurological symptoms and radiological characteristics of the tumour. Sixteen patients were evaluated. A subset of patients was identified with clearly impaired cognition. Patients with cognitive impairment often had large tumours in the left frontal lobe, were relatively young, and most of them were males. We conclude that cognitive dysfunction may be present already at early stage of disease, and that early identification of patients at risk is warranted.
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| 5. |
- Hedlund, Mattias, et al.
(författare)
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Is better preservation of eccentric strength after stroke due to altered prefrontal function?
- 2016
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Ingår i: Neurocase. - : Informa UK Limited. - 1355-4794 .- 1465-3656. ; 22:2, s. 229-242
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Tidskriftsartikel (refereegranskat)abstract
- Ventrolateral prefrontal cortex (VLPFC) is part of a network that exerts inhibitory control over the motor cortex (MC). Recently, we demonstrated that VLPFC was more activated during imagined maximum eccentric than during imagined concentric contractions in healthy participants. This was accompanied with lower activation levels within motor regions during imagined eccentric contractions. The aim was to test a novel hypothesis of an involvement of VLPFC in contraction mode-specific modulation of force. Functional magnetic resonance imaging was used to examine differences in VLPFC and motor regions during the concentric and the eccentric phases of imagined maximum contractions in a selected sample of subjects with stroke (n = 4). The subjects were included as they exhibited disturbed modulation of force. The previously demonstrated pattern within VLPFC was evident only on the contralesional hemisphere. On the ipsilesional hemisphere, the recruitment in VLPFC was similar for both modes of contractions. The findings support a hypothesis of the involvement of VLPFC in contraction mode-specific modulation of maximum force production. A disturbance of this system might underlie the lack of contraction mode-specific modulation commonly found among stroke subjects, often expressed as an increased ratio between eccentric and concentric strength.
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| 6. |
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| 7. |
- Mårtensson, Frida, et al.
(författare)
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Sensory-specific anomic aphasia following left occipital lesions : Data from free oral descriptions of concrete word meanings
- 2014
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Ingår i: Neurocase. - : Informa UK Limited. - 1355-4794 .- 1465-3656. ; 20:2, s. 192-207
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Tidskriftsartikel (refereegranskat)abstract
- The present study investigated hierarchical lexical semantic structure in oral descriptions of concrete word meanings produced by a subject (ZZ) diagnosed with anomic aphasia due to left occipital lesions. The focus of the analysis was production of a) nouns at different levels of semantic specificity (e.g., "robin"-"bird"-"animal") and b) words describing sensory or motor experiences (e.g., "blue," "soft," "fly"). Results show that in contrast to healthy and aphasic controls, who produced words at all levels of specificity and mainly vision-related sensory information, ZZ produced almost exclusively nouns at the most non-specific levels and words associated with sound and movement.
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| 8. |
- Olsson, Carl-Johan, et al.
(författare)
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Brain simulation of action may be grounded in physical experience
- 2011
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Ingår i: Neurocase. - : Taylor & Francis. - 1355-4794 .- 1465-3656. ; 17:6, s. 501-505
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Tidskriftsartikel (refereegranskat)abstract
- An intriguing quality of our brain is that when actions are imagined, corresponding brain regions are recruited as when the actions are actually performed. It has been hypothesized that the similarity between real and simulated actions depends on the nature of motor representations. Here we tested this hypothesis by examining S.D., who never used her legs but is an elite wheel chair athlete. Controls recruited motor brain regions during imagery of stair walking and frontal regions during imagery of wheel chair slalom. S.D. showed the opposite pattern. Thus, brain simulation of actions may be grounded in specific physical experiences.
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| 9. |
- Philipsson, Johanna, et al.
(författare)
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Acute severe depression induced by stimulation of the right globus pallidus internus
- 2017
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Ingår i: Neurocase. - : Routledge. - 1355-4794 .- 1465-3656. ; 23:1, s. 84-87
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Tidskriftsartikel (refereegranskat)abstract
- Depressive symptoms may occur after Deep Brain Stimulation (DBS) in the subthalamic nucleus. This is often explained by reduced pharmacological treatment after surgery, and not as a direct effect of DBS. Pallidal DBS seems not to be associated with such side effects and have not, to our knowledge, previously been reported. We present a patient with acute depressive symptoms induced by pallidal DBS. We believe this case strengthen the hypothesis that the basal ganglia and structures involved in the functional connectome of these nucleuses play a role not only in regulation of movement but also in regulation of mood.
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| 10. |
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