SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:1388 9842 "

Sökning: L773:1388 9842

  • Resultat 1-10 av 688
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Persson, H, et al. (författare)
  • Neurohormonal activation in heart failure after acute myocardial infarction treated with beta-receptor antagonists
  • 2002
  • Ingår i: European Journal of Heart Failure. - 1879-0844 .- 1388-9842. ; 4:1, s. 73-82
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Few studies have described how neurohormonal activation is influenced by treatment with beta-receptor antagonists in patients with heart failure after acute myocardial infarction. The aims were to describe neurohormonal activity in relation to other variables and to investigate treatment effects of a beta, receptor-antagonist compared to a partial beta, receptor-agonist. Methods: Double-blind, randomized comparison of metoprolol 50-100 mg b.i.d. (n = 74), and xamoterol 100-200 mg b.i.d (n = 67). Catecholamines, neuropeptide Y-like immunoreactivity (NPY-LI), renin activity, and N-terminal pro-atrial natriuretic factor (N-ANF) were measured in venous plasma before discharge and after 3 months. Clinical and echocardiographic variables were assessed. Results: N-ANF showed the closest correlations to clinical and echo cardiographic measures of heart failure severity, e.g. NYHA functional class, furosemide dose, exercise tolerance, systolic and diastolic function. Plasma norepinephrine, dopamine and renin activity decreased after 3 months on both treatments, in contrast to a small increase in NPY-LI which was greater (by 3.9 pmol/l, 95% CI 1.2-6.6) in the metoprolol group. N-ANF increased on metoprolol, and decreased on xamoterol (difference: 408 pmol/l, 95% CI 209-607). Increase above median of NPY-LI (> 25.2 pmol/l, odds ratio 2.8, P = 0.0050) and N-ANF (> 1043 pmol/l, odds ratio 2.8, P = 0.0055) were related to long term (mean follow-up 6.8 years) cardiovascular mortality. Conclusions: Decreased neurohormonal activity, reflecting both the sympathetic nervous system and the renin-angiotensin system, was found 3 months after an acute myocardial infarction with heart failure treated with beta-receptor antagonists. The small increase in NPY-LI may suggest increased sympathetic activity or reduced clearance from plasma. The observed changes of N-ANF may be explained by changes in cardiac preload, renal function, and differences in beta-receptor mediated inhibition of atrial release of N-ANF. NPY-LI, and N-ANF at discharge were related to long term cardiovascular mortality. (C) 2002 European Society of Cardiology. All rights reserved.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  • Andersson, Bert, 1952, et al. (författare)
  • Angiotensin-II type 1 receptor gene polymorphism and long-term survival in patients with idiopathic congestive heart failure.
  • 1999
  • Ingår i: European journal of heart failure. - 1388-9842. ; 1:4, s. 363-9
  • Tidskriftsartikel (refereegranskat)abstract
    • It has been suggested that a genetic polymorphism in the angiotensin II type 1 receptor gene (ATRG) and the ACE gene DD genotype might have a synergistic influence on the risk of developing cardiovascular disease.To study the possible interaction between polymorphisms in the ACE gene and the ATRG, regarding survival and left ventricular function.Polymorphism of the two genes was studied in a population-based cohort of 194 patients with idiopathic heart failure, recruited from the western part of Sweden 1985-1988. The patients were investigated by echocardiography. The survival status was checked during the 7-year follow-up period.Although there was no statistically significant additive risk of the ATRG polymorphism, patients carrying the ACE gene DD genotype in combination with a C allele of the ATRG tended to have a poorer prognosis. DD +AA, OR 1.24 (95% CI 0.67-2.32, P = 0.49); DD +AC, OR 1.64 (95% CI 0.95-2.83, P = 0.08); DD + CC, OR 3.54 95% CI 0.78-16.1, P = 0.10); DD +AC/CC, OR 1.84 (95% CI 1.10-3.08, P = 0.02). Patients with the DD +AC/CC genotypes tended to have lower ejection fraction and increased left ventricular mass.There was a trend toward a worse prognosis in patients with the combination of a C-allele in the ATRG and the ACE gene DD genotype, suggesting an interaction of these two genetic polymorphisms on disease severity.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 688
Typ av publikation
tidskriftsartikel (556)
konferensbidrag (121)
forskningsöversikt (10)
recension (1)
Typ av innehåll
refereegranskat (490)
övrigt vetenskapligt/konstnärligt (198)
Författare/redaktör
Lund, LH (114)
Swedberg, Karl, 1944 (106)
Jaarsma, Tiny (82)
Dahlström, Ulf (58)
Savarese, G (56)
Lund, Lars H. (55)
visa fler...
Linde, C (44)
Savarese, Gianluigi (40)
Ponikowski, Piotr (33)
Dahlstrom, U (33)
Komajda, M. (30)
Anker, Stefan D. (30)
Filippatos, Gerasimo ... (30)
Metra, M (29)
Dickstein, Kenneth (29)
Hage, C (29)
McMurray, J. J. V. (28)
van Veldhuisen, Dirk ... (28)
Zannad, F (27)
Metra, Marco (27)
Benson, Lina (27)
Solomon, S. D. (26)
Ruschitzka, F (26)
Coats, AJS (25)
Lainscak, M (25)
Chioncel, Ovidiu (25)
Coats, Andrew J. S. (24)
McMurray, John J. V. (24)
Filippatos, G (23)
Tavazzi, L. (22)
McMurray, J. J. (22)
Rosano, Giuseppe M. ... (22)
Persson, H (21)
Piepoli, Massimo F. (21)
Ruschitzka, Frank (20)
de Boer, Rudolf A. (19)
Seferovic, Petar (19)
Ponikowski, P (19)
Rosano, G (18)
Bohm, M (18)
Anker, SD (18)
Solomon, Scott D. (18)
Packer, M. (18)
Braunschweig, F (17)
Strömberg, Anna (17)
Lund, L (17)
Jhund, Pardeep S. (17)
Hill, Loreena (17)
Mullens, Wilfried (17)
van Veldhuisen, D. J ... (17)
visa färre...
Lärosäte
Karolinska Institutet (361)
Linköpings universitet (165)
Göteborgs universitet (164)
Uppsala universitet (69)
Lunds universitet (32)
Umeå universitet (29)
visa fler...
Jönköping University (13)
Örebro universitet (5)
Linnéuniversitetet (5)
Kungliga Tekniska Högskolan (4)
Högskolan i Halmstad (4)
Högskolan Dalarna (4)
Malmö universitet (3)
Högskolan i Skövde (2)
Stockholms universitet (1)
Mälardalens universitet (1)
Chalmers tekniska högskola (1)
RISE (1)
Karlstads universitet (1)
Röda Korsets Högskola (1)
visa färre...
Språk
Engelska (687)
Odefinierat språk (1)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (366)
Samhällsvetenskap (9)
Naturvetenskap (1)
Lantbruksvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy