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- Haese, A, et al.
(författare)
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Isoformen des freien prostataspezifischen Antigens
- 2004
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Ingår i: Der Urologe. - : Springer Science and Business Media LLC. - 0340-2592. ; 43:6, s. 675-679
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Tidskriftsartikel (refereegranskat)abstract
- Detection of prostate-specific antigen remains the mainstay in the early detection of prostate cancer. A problem yet unsolved is the lack of specificity of this organ- but not cancer-specific marker, which generates subsequent, invasive procedures in a high number of patients without detecting prostate cancer. While the separate detection of free PSA and the ratio of free to total PSA has significantly improved specificity while maintaining high sensitivity, the number of patients undergoing unnecessary further diagnostics is still of concern. In this context, the evolving knowledge on isoforms of free PSA is a major focus of current research. Isoforms of free PSA are variants of free PSA that circulate, e.g., as precursor forms, internally cleaved variants of intact molecules, and are suggested to be either more associated with cancer or more with benign diseases. This article describes biochemical and clinical properties of the isoforms of free PSA.
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- Ljungberg, Börje
(författare)
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Prognostic factors in renal cell carcinoma
- 2004
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Ingår i: Scandinavian Journal of Surgery. - Helsinki : Springer. - 1457-4969 .- 1799-7267. ; 43:Suppl 3, s. 119-120
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Tidskriftsartikel (refereegranskat)
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| 7. |
- von Rundstedt, F. -C., et al.
(författare)
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Patients' acceptance of urinary diversion. The pouch of Sisyphus
- 2012
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Ingår i: Der Urologe. - : Springer Science and Business Media LLC. - 0340-2592 .- 1433-0563. ; 51:4, s. 515-521
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Tidskriftsartikel (refereegranskat)abstract
- It is important that any patient with a urinary diversion can accept the psychological impact alongside the surgical and physical aspects. However, there are currently no validated methods or instruments available to allow direct measurement of this phenomenon in these patients. Health-related quality of life (HRQoL) is often high following different types of urinary diversion - this may suggest a high acceptance level and thus may act as a secondary end point. Such an assessment is a retrospective validation of successful patient selection, allowing us to redirect the nihilistic misinterpretation that urologists should return to offering ileal conduits as a standard. In modern urinary diversion, high patient acceptance develops from comprehensive counselling providing a realistic expectation, careful patient-to-method-matching, strict adherence to surgical detail during the procedure and a meticulous lifelong follow-up. Coping strategies, disease-related social support and confidence in the success of treatment are among other factors which contribute to acceptance of urinary reconstruction as either independent or combined factors. Significant experience is required in every respect, as misjudgement and mistakes in any of these issues may be detrimental to the patients' health. It should be acknowledged that there is no 'best' urinary diversion in general terms. A reconstructive surgeon must have all techniques available and choices need to be tailored to the individual patient.
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| 8. |
- Wagenlehner, F. M. E., et al.
(författare)
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Antibiotikaprophylaxe in der Urologie
- 2011
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Ingår i: Der Urologe. - : Springer Science and Business Media LLC. - 0340-2592 .- 1433-0563. ; 50:11, s. 1469-1478
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Tidskriftsartikel (refereegranskat)abstract
- The aim of perioperative antibiotic prophylaxis is the prevention of surgical site infections and urinary tract infections during urological procedures. The indication for antibiotic prophylaxis comprises several risk factors such as the degree of contamination of the operative site, duration of surgery, implantation of devices and comorbidities of the individual patient. In general this involves a single antibiotic administration before the operative procedure. The antibiotic prophylaxis is part of the total antibiotic consumption and thus a factor contributing to emergence of antibiotic resistance. It is not a substitute for hygiene measures or operative precision.
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