| 1. |
- Adielsson, A, et al.
(författare)
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Increase in survival and bystander CPR in out-of-hospital shockable arrhythmia : bystander CPR and female gender are predictors of improved outcome. Experiences from Sweden in an 18-year perspective
- 2011
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Ingår i: Heart. - : B M J Group. - 1355-6037 .- 1468-201X. ; 97:17, s. 1391-1396
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Tidskriftsartikel (refereegranskat)abstract
- Objectives In a national perspective, to describe survival among patients found in ventricular fibrillation or pulseless ventricular tachycardia witnessed by a bystander and with a presumed cardiac aetiology and answer two principal questions: (1) what are the changes over time? and (2) which are the factors of importance? Design Observational register study. Setting Sweden. Patients All patients included in the Swedish Out of Hospital Cardiac Arrest Register between 1 January 1990 and 31 December 2009 who were found in bystander-witnessed ventricular fibrillation with a presumed cardiac aetiology. Interventions Bystander cardiopulmonary resuscitation (CPR) and defibrillation. Main outcome measures Survival to 1 month. Results In all, 7187 patients fulfilled the set criteria. Age, place of out-of-hospital cardiac arrest (OHCA) and gender did not change. Bystander CPR increased from 46% to 73%; 95% CI for OR 1.060 to 1.081 per year. The median delay from collapse to defibrillation increased from 12 min to 14 min (p for trend 0.0004). Early survival increased from 28% to 45% (95% CI 1.044 to 1.065) and survival to 1 month increased from 12% to 23% (95% CI 1.058 to 1.086). Strong predictors of early and late survival were a short interval from collapse to defibrillation, bystander CPR, female gender and OHCA outside the home. Conclusion In a long-term perspective in Sweden, survival to 1 month after ventricular fibrillation almost doubled. This was associated with a marked increase in bystander CPR. Strong predictors of outcome were a short delay to defibrillation, bystander CPR, female gender and place of collapse.
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| 2. |
- Alasdair, Skelton, et al.
(författare)
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Spatial coupling between spilitization and carbonation ofbasaltic sills in SW Scottish Highlands: evidence of amineralogical control of metamorphic fluid flow
- 2011
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Ingår i: Geofluids. - : Wiley. - 1468-8115 .- 1468-8123. ; 11:3, s. 245-259
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Tidskriftsartikel (refereegranskat)abstract
- In a geochemical and petrological analysis of overprinting episodes of fluid–rock interaction in a well-studied metabasaltic sill in the SW Scottish Highlands, we show that syn-deformational access of metamorphic fluids and consequent fluid–rock interaction is at least in part controlled by preexisting mineralogical variations. Lithological and structural channelling of metamorphic fluids along the axis of the Ardrishaig Anticline, SW Scottish Highlands, caused carbonation of metabasaltic sills hosted by metasedimentary rocks of the Argyll Group in the Dalradian Supergroup. Analysis of chemical and mineralogical variability across a metabasaltic sill at Port Cill Maluaig shows that carbonation at greenschist to epidote–amphibolites facies conditions caused by infiltration of H2O-CO2 fluids was controlled by mineralogical variations, which were present before carbonation occurred. This variability probably reflects chemical and mineralogical changes imparted on the sill during premetamorphic spilitization. Calculation of precarbonation mineral modes reveals heterogeneous spatial distributions of epidote, amphibole, chlorite and epidote. This reflects both premetamorphic spilitization and prograde greenschist facies metamorphism prior to fluid flow. Spilitization caused albitization of primary plagioclase and spatially heterogeneous growth of epidote ± calcic amphibole ± chlorite ± quartz ± calcite. Greenschist facies metamorphism caused breakdown of primary pyroxene and continued, but spatially more homogeneous, growth of amphibole + chlorite ± quartz. These processes formed diffuse epidote-rich patches or semi-continuous layers. These might represent precursors of epidote segregations, which are better developed elsewhere in the SW Scottish Highlands. Chemical and field analyses of epidote reveal the evidence of local volume fluctuations associated with these concentrations of epidote. Transient permeability enhancement associated with these changes may have permitted higher fluid fluxes and therefore more extensive carbonation. This deflected metamorphic fluid such that its flow direction became more layer parallel, limiting propagation of the reaction front into the sill interior.
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| 3. |
- Alfredsson, Joakim, et al.
(författare)
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Predicting the risk of bleeding during dual antiplatelet therapy after acute coronary syndromes
- 2017
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Ingår i: Heart. - : BMJ PUBLISHING GROUP. - 1355-6037 .- 1468-201X. ; 103:15, s. 1168-1176
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Tidskriftsartikel (refereegranskat)abstract
- Objectives Dual antiplatelet therapy (DAPT) with aspirin + a P2Y12 inhibitor is recommended for at least 12 months for patients with acute coronary syndrome (ACS), with shorter durations considered for patients with increased bleeding risk. However, there are no decision support tools available to predict an individual patients bleeding risk during DAPT treatment in the post-ACS setting. Methods To develop a longitudinal bleeding risk prediction model, we analysed 9240 patients with unstable angina/non-ST segment elevation myocardial infarction (NSTEMI) from the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes (TRILOGY ACS) trial, who were managed without revascularisation and treated with DAPT for a median of 14.8 months. Results We identified 10 significant baseline predictors of non-coronary artery bypass grafting (CABG)-related Global Use of Strategies to Open Occluded Arteries (GUSTO) severe/life-threatening/moderate bleeding: age, sex, weight, NSTEMI (vs unstable angina), angiography performed before randomisation, prior peptic ulcer disease, creatinine, systolic blood pressure, haemoglobin and treatment with beta-blocker. The five significant baseline predictors of Thrombolysis In Myocardial Infarction (TIMI) major or minor bleeding included age, sex, angiography performed before randomisation, creatinine and haemoglobin. The models showed good predictive accuracy with Therneaus C-indices: 0.78 (SE=0.024) for the GUSTO model and 0.67 (SE=0.023) for the TIMI model. Internal validation with bootstrapping gave similar C-indices of 0.77 and 0.65, respectively. External validation demonstrated an attenuated C-index for the GUSTO model (0.69) but not the TIMI model (0.68). Conclusions Longitudinal bleeding risks during treatment with DAPT in patients with ACS can be reliably predicted using selected baseline characteristics. The TRILOGY ACS bleeding models can inform riskbenefit considerations regarding the duration of DAPT following ACS.
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| 4. |
- Andell, Pontus, et al.
(författare)
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Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study
- 2017
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Ingår i: Heart. - : BMJ. - 1355-6037 .- 1468-201X. ; 103:21, s. 1696-1703
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Transitions in the spectrum of valvular heart diseases (VHDs) in developed countries over the 20th century have been reported from clinical case series, but large, contemporary population-based studies are lacking.Methods: We used nationwide registers to identify all patients with a first diagnosis of VHD at Swedish hospitals between 2003 and 2010. Age-stratified and sex-stratified incidence of each VHD and adjusted comorbidity profiles were assessed.Results: In the Swedish population (n=10 164 211), the incidence of VHD was 63.9 per 100 000 person-years, with aortic stenosis (AS; 47.2%), mitral regurgitation (MR; 24.2%) and aortic regurgitation (AR; 18.0%) contributing most of the VHD diagnoses. The majority of VHDs were diagnosed in the elderly (68.9% in subjects aged ≥65 years), but pulmonary valve disease incidence peaked in newborns. Incidences of AR, AS and MR were higher in men who were also more frequently diagnosed at an earlier age. Mitral stenosis (MS) incidence was higher in women. Rheumatic fever was rare. Half of AS cases had concomitant atherosclerotic vascular disease (48.4%), whereas concomitant heart failure and atrial fibrillation were common in mitral valve disease and tricuspid regurgitation. Other common comorbidities were thoracic aortic aneurysms in AR (10.3%), autoimmune disorders in MS (24.5%) and abdominal hernias or prolapse in MR (10.7%) and TR (10.3%).Conclusions: Clinically diagnosed VHD was primarily a disease of the elderly. Rheumatic fever was rare in Sweden, but specific VHDs showed a range of different comorbidity profiles . Pronounced sex-specific patterns were observed for AR and MS, for which the mechanisms remain incompletely understood.
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| 5. |
- Andersson, David Emanuel, et al.
(författare)
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Unemployment in European regions: structural problems versus the Eurozone hypothesis
- 2015
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Ingår i: Journal of Economic Geography. - Oxford University Press : Oxford University Press (OUP). - 1468-2702 .- 1468-2710. ; 15:5, s. 883-905
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Tidskriftsartikel (refereegranskat)abstract
- Unemployment rates differ dramatically across European regions. This article analyses these differences by integrating institutional and spatial perspectives into a unified dynamic framework distinguishing between slow and fast processes of change. The framework forms the basis for an econometric model that is used to analyse labour market differences among European Nomenclature des unités territoriales statistiques 2 regions. The results of random-effects models indicate that four key factors—all of which are of the slowly changing type—explain a large part of the variation in unemployment as well as employment rates. Flexible labour market regulations and above-average levels of interpersonal trust are institutional factors that reduce unemployment. Accessibility factors such as inter-regional transport connectivity and local access to skilled workers have similarly substantial effects. Whether a region belongs to the Eurozone or not seems to be less important.
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| 6. |
- Andersson, Martin, 1977-, et al.
(författare)
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Local entrepreneurship clusters in cities
- 2016
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Ingår i: Journal of Economic Geography. - : Oxford University Press. - 1468-2702 .- 1468-2710. ; 16:1, s. 39-66
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Tidskriftsartikel (refereegranskat)abstract
- We show that entrepreneurs are co-located within cities. One plausible source of such spatial clustering is local social interactions, where individuals' decisions to become entrepreneurs are influenced by entrepreneurial neighbors. Using geo-coded matched employer-employee data for Sweden, we find that sharing residential neighborhood with established entrepreneurs has a statistically significant and robust influence on the probability that an individual leaves employment for entrepreneurship. An otherwise average neighborhood with a 5% point higher entrepreneurial intensity, all else equal, produces between six and seven additional entrepreneurs per square kilometer, each year. Our estimates suggest a local feedback-effect in which the presence of established entrepreneurs in a neighborhood influences the emergence of new local entrepreneurs. Our analysis supports the conjecture that social interaction effects constitute a mechanism by which local entrepreneurship clusters in cities develop and persist over time.
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| 7. |
- Andersson, Martin, et al.
(författare)
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Sources of persistence in regional start-up rates-evidence from Sweden
- 2011
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Ingår i: Journal of Economic Geography. - : Oxford University Press (OUP). - 1468-2702 .- 1468-2710. ; 11:1, s. 179-201
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Tidskriftsartikel (refereegranskat)abstract
- This article assesses the spatial-temporal persistence of a dynamic phenomenon: start-ups. Two mechanisms that explain persistence in start-up rates are distinguished: (i) determinants of start-ups that are spatially 'sticky' and durable and (ii) path dependence in start-up activities in the form of a response mechanism between previous and current start-up activities. A dynamic panel analysis of the relationship between lagged start-up rates and current start-up rates confirms that both effects are important in explaining persistence. The second mechanism implies a regional dimension in persistence, such that regions with high levels of start-up rates will exhibit stronger persistence. We find empirical evidence of this using quantile regression techniques.
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| 8. |
- Aspers, Patrik
(författare)
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Using design for upgrading in the fashion industry
- 2010
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Ingår i: Journal of Economic Geography. - : Oxford University Press (OUP). - 1468-2702 .- 1468-2710. ; 10:2, s. 189-207
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Forskningsöversikt (refereegranskat)abstract
- The purpose of the article is to analyze upgrading by looking at the design of fashion garments. To that end, I use the theoretical concept of contextual knowledge to understand the problems faced by firms, and their staff, that want to upgrade through design. Contextual knowledge combines a general knowledge of fashion with the lifeworld that actors use for interpretation of fashion. Lifeworld is a notion which refers to what is taken for granted. Producers and consumers in the global fashion industry live in different lifeworlds. The text discusses upgrading strategies of garment manufacturers, drawing on unique empirical material. It provides a theoretical tool for analyzing culturally primed production in a global setting.
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| 9. |
- Bahit, M. Cecilia, et al.
(författare)
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Non-major bleeding with apixaban versus warfarin in patients with atrial fibrillation
- 2017
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Ingår i: Heart. - : BMJ. - 1355-6037 .- 1468-201X. ; 103:8, s. 623-628
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Tidskriftsartikel (refereegranskat)abstract
- Objective We describe the incidence, location and management of non-major bleeding, and assess the association between non-major bleeding and clinical outcomes in patients with atrial fibrillation (AF) receiving anticoagulation therapy enrolled in Apixaban for Reduction in Stroke and other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE). Methods We included patients who received >= 1 dose of study drug (n= 18 140). Non-major bleeding was defined as the first bleeding event considered to be clinically relevant non-major (CRNM) or minor bleeding, and not preceded by a major bleeding event. Results Non-major bleeding was three times more common than major bleeding (12.1% vs 3.8%). Like major bleeding, non-major bleeding was less frequent with apixaban (6.4 per 100 patient-years) than warfarin (9.4 per 100 patient-years) (adjusted HR 0.69, 95% CI 0.63 to 0.75). The most frequent sites of non-major bleeding were haematuria (16.4%), epistaxis (14.8%), gastrointestinal (13.3%), haematoma (11.5%) and bruising/ecchymosis (10.1%). Medical or surgical intervention was similar among patients with non-major bleeding on warfarin versus apixaban (24.7% vs 24.5%). A change in antithrombotic therapy (58.6% vs 50.0%) and permanent study drug discontinuation (5.1% (61) vs 3.6% (30), p=0.10) was numerically higher with warfarin than apixaban. CRNM bleeding was independently associated with an increased risk of overall death (adjusted HR 1.70, 95% CI 1.32 to 2.18) and subsequent major bleeding (adjusted HR 2.18, 95% CI 1.56 to 3.04). Conclusions In ARISTOTLE, non-major bleeding was common and substantially less frequent with apixaban than with warfarin. CRNM bleeding was independently associated with a higher risk of death and subsequent major bleeding. Our results highlight the importance of any severity of bleeding in patients with AF treated with anticoagulation therapy and suggest that non-major bleeding, including minor bleeding, might not be minor.
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| 10. |
- Baltzopoulos, Apostolos, et al.
(författare)
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Spin-offs: Why geography matters
- 2016
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Ingår i: Journal of Economic Geography. - : Oxford. - 1468-2702 .- 1468-2710. ; 16:2, s. 273--303
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Tidskriftsartikel (refereegranskat)abstract
- Based on unique data covering individuals, firms, industries and regions for the 1999–2005 period, we contribute with new knowledge concerning the impact of regional variables on spin-offs. Implementing a large number of controls, as well as different estimation techniques and robustness tests, we show that Jacobian externalities have a positive effect on spin-offs. Moreover, using an entropy measure to disentangle unrelated and related variety (RV), we conclude that the effect is confined to RV. These findings are likely to be associated with strong welfare effects: a standard deviation increase (decrease) in related (unrelated) variety increases spin-off propensity by approximately 25%. Other variables are shown to have economic effects of a similar magnitude but may have a different effect across sectors. Sensitivity analyses indicate that the impact of other determinants proposed in the literature (e.g., Marshallian externalities and scale effects) is too small to be detected.
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