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Träfflista för sökning "L773:1471 4914 OR L773:1471 499X "

Sökning: L773:1471 4914 OR L773:1471 499X

  • Resultat 1-10 av 47
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  • Cao, Yihai (författare)
  • Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis
  • 2013
  • Ingår i: Trends in Molecular Medicine. - : Elsevier. - 1471-4914 .- 1471-499X. ; 19:8, s. 460-473
  • Forskningsöversikt (refereegranskat)abstract
    • Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are frequently expressed in various tumors and their expression levels correlate with tumor growth, invasiveness, drug resistance, and poor clinical outcomes. Emerging experimental evidence demonstrates that PDGFs exhibit multiple functions in modulation of tumor growth, metastasis, and the tumor microenvironment by targeting malignant cells, vascular cells, and stromal cells. Understanding PDGF PDGFR-mediated molecular signaling may provide new mechanistic rationales for optimizing current cancer therapies and the development of future novel therapeutic modalities.
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  • Carter, SF, et al. (författare)
  • Astrocyte Biomarkers in Alzheimer's Disease
  • 2019
  • Ingår i: Trends in molecular medicine. - : Elsevier BV. - 1471-499X .- 1471-4914. ; 25:2, s. 77-95
  • Tidskriftsartikel (refereegranskat)
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  • Claesson-Welsh, Lena, et al. (författare)
  • Permeability of the Endothelial Barrier : Identifying and Reconciling Controversies
  • 2021
  • Ingår i: Trends in Molecular Medicine. - : Elsevier. - 1471-4914 .- 1471-499X. ; 27:4, s. 314-331
  • Forskningsöversikt (refereegranskat)abstract
    • Leakage from blood vessels into tissues is governed by mechanisms that control endothelial barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes to many conditions and can influence disease morbidity and treatment. Diverse approaches used to study endothelial permeability have yielded a wealth of valuable insights. Yet, ongoing questions, technical challenges, and unresolved controversies relating to the mechanisms and relative contributions of barrier regulation, transendothelial sieving, and transport of fluid, solutes, and particulates complicate interpretations in the context of vascular physiology and pathophysiology. Here, we describe recent in vivo findings and other advances in understanding endothelial barrier function with the goal of identifying and reconciling controversies over cellular and molecular processes that regulate the vascular barrier in health and disease.
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  • Hou, Meijun, et al. (författare)
  • Human dopaminergic system in the exercise-cognition link
  • 2024
  • Ingår i: Trends in Molecular Medicine. - : Elsevier. - 1471-4914 .- 1471-499X.
  • Tidskriftsartikel (refereegranskat)abstract
    • While the dopaminergic system is important for cognitive processes, it is also sensitive to the influence of physical activity (PA). We summarize current evidence on whether PA-related changes in the human dopaminergic system are associated with alterations in cognitive performance, discuss recent advances, and highlight challenges and opportunities for future research.
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  • Resultat 1-10 av 47

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