| 1. |
- Harandi, Ali M, 1968, et al.
(författare)
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CpG DNA as a potent inducer of mucosal immunity: implications for immunoprophylaxis and immunotherapy of mucosal infections.
- 2004
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Ingår i: Current opinion in investigational drugs (London, England : 2000). - 1472-4472. ; 5:2, s. 141-5
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Tidskriftsartikel (refereegranskat)abstract
- Recent advances in immunology reveal that vertebrate innate immune systems use pattern-recognition receptors, of which the best characterized is the toll-like receptor (TLR) family, to specifically detect pathogen-associated molecular patterns (PAMPs) present in infectious agents. Based on this, use of synthetic PAMPs has attracted much interest for specific immunoprophylaxis and immunotherapy purposes. Among the PAMPs, immunostimulatory CpG DNA, a TLR9 ligand, displays promising potent immunostimulatory and adjuvanticity in different settings. In this review, recent developments in the use of CpG DNA for inducing immunity in the mucosal tissues will be highlighted.
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| 2. |
- Hedlund, Petter
(författare)
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PT-141 Palatin.
- 2004
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Ingår i: Current opinion in investigational drugs (London, England : 2000). - 1472-4472. ; 5:4, s. 456-62
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Tidskriftsartikel (refereegranskat)abstract
- Palatin, under license from Competitive Technology, is developing the peptide PT-141, a synthetically modified analog of PT-14, as a nasal spray for the potential treatment of erectile dysfunction (ED) and female sexual dysfunction. In September 2003, Palatin had completed a phase IIb trial in patients with ED and in February 2004, Palatin planned to start phase III trials in early 2005.
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| 3. |
- Jardemark, Kent, et al.
(författare)
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Dopamine D3 and D4 receptor antagonists in the treatment of schizophrenia.
- 2002
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Ingår i: Curr Opinion in Investigational Drugs. ; 3:1, s. 101-5
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Forskningsöversikt (övrigt vetenskapligt/konstnärligt)abstract
- The findings that dopamine D3 and D4 receptors are highly expressed in limbic and cortical areas (D4 more than D3), and the fact that the atypical drug clozapine has preferential affinity for the D4 receptors have suggested an involvement of these receptors in schizophrenia. Subsequently, many pharmaceutical companies have pursued the approach of developing selective dopamine D3 or D4 antagonists as potential antipsychotics. This review will discuss the current status of selective dopamine D3 and D4 receptor antagonists for the treatment of schizophrenia.
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| 4. |
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| 5. |
- Lindén, Anders, 1961
(författare)
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Rationale for targeting interleukin-17 in the lungs
- 2003
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Ingår i: Current opinion in investigational drugs (London, England. - 1472-4472. ; 4:11, s. 1304-12
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Tidskriftsartikel (refereegranskat)abstract
- An increasing body of evidence suggests that an exaggerated accumulation of activated neutrophils in the airways can cause decline of the clinical state in several lung diseases, including acute, severe asthma. In spite of this, an effective pharmacotherapy against this type of exaggerated neutrophil activity has yet to be developed. This review presents the scientific rationale for targeting the T-cell cytokine interleukin (IL)-17 in inflammatory lung diseases, to normalize neutrophil activity. Evidence leads to the conclusion that the production and release of IL-17 orchestrates neutrophil activity in the lungs. Hypothetically, local blockade of IL-17 may prove effective to normalize exaggerated neutrophil activity in lung diseases.
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| 6. |
- Selivanova, G
(författare)
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Mutant p53: the loaded gun
- 2001
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Ingår i: Current opinion in investigational drugs (London, England : 2000). - 1472-4472. ; 2:8, s. 1136-41
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Tidskriftsartikel (refereegranskat)
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| 7. |
- Whiss, Per A, 1966-
(författare)
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Pexelizumab Alexion
- 2002
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Ingår i: Current Opinion in Investigational Drugs. - 1472-4472. ; 3:6, s. 870-877
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Tidskriftsartikel (refereegranskat)
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| 8. |
- Mattsson, Elisabet, 1959-, et al.
(författare)
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Voices of women in homelessness during the outbreak of the COVID-19 pandemic : a co-created qualitative study
- 2023
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Ingår i: BMC Women's Health. - : BioMed Central (BMC). - 1472-6874. ; 23
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundWomen in homelessness face extreme health- and social inequities. It could be postulated that during societal crises, they become even more vulnerable. Thus, the aim was to explore experiences related to the COVID-19 pandemic among women in homelessness.MethodsTen interviews were conducted with women in homelessness, in Stockholm, Sweden, using researcher-driven photo elicitation. The data analysis was guided by the DEPICT model for collaborative data analysis and a qualitative content analysis was performed. A collaborative reference group of women with lived experience of homelessness contributed to the research process through designing the data collection, performing the data analysis, and providing feedback during report writing.ResultsFor women in homelessness, the COVID-19 pandemic was adding insult to injury, as it significantly affected everyday life and permeated most aspects of existence, leading to diminished interactions with others and reduced societal support. Thus, in an already dire situation, the virus amplified health- and social issues to another level. The women strived to find their balance on the shifting sands of guidelines and restrictions due to the pandemic. Adhering to the new social distancing rules and guidelines in line with the rest of society, was simply impossible when experiencing homelessness. However, for some women the pandemic was nothing but a storm in a teacup. The harsh reality continued irrespectively, living one day at a time and prioritizing provision for basic human needs.ConclusionsThe COVID-19 pandemic and homelessness can be viewed as two intersecting crises. However, the women’s aggregated experiences were greater than the sum of experiencing homelessness and meeting the threat of the virus. Gender, exposure to violence, poverty, social isolation, and substance use were additional factors that further marginalized the women during the pandemic. To rebuild a better and more sustainable post-pandemic future for all, global commitment to ending homelessness is crucial. In addition, addressing social determinants of health must be the number one health intervention.
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| 9. |
- Jensen, Ulf J., et al.
(författare)
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The role of a simulator-based course in coronary angiography on performance in real life cath lab
- 2014
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Ingår i: BMC Medical Education. - : Springer Science and Business Media LLC. - 1472-6920. ; 14, s. 49-
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Tidskriftsartikel (refereegranskat)abstract
- Background: The aim of this study was to explore if a course consisting of lectures combined with simulator training in coronary angiography (CA) could accelerate the early learning curve when performing CA on patients. Knowledge in performing CA is included in the curriculum for the general cardiologist. The method, according to American College of Cardiology and European Society of Cardiology guidelines, for this training is not well defined but simulator training is proposed to be an option. However, the transfer effect from a CA simulator to performance in real world cath lab is not validated. Methods: Fifty-four residents without practical skills in CA completed the course and 12 continued to training in invasive cardiology. These residents were tracked in the Swedish Coronary Angiography and Angioplasty Registry and compared to a control group of 46 novel operators for evaluation of performance metrics. A total of 4472 CAs were analyzed. Results: Course participants demonstrated no consistent acceleration in the early learning curve in real world cath lab. They had longer fluoroscopy time compared to controls (median 360 seconds (IQR 245-557) vs. 289 seconds (IQR 179-468), p < 0.001). Safety measures also indicated more complications appearing at the ward, in particular when using the femoral approach (6.25% vs. 2.53%, p < 0.001). Conclusions: Since the results of this retrospective non-randomized study were negative, the role of a structured course including simulator training for skills acquisition in CA is still uncertain. Randomized transfer studies are warranted to justify further use of simulators for training in CA
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