| 1. |
|
|
| 2. |
- Falk, Peter, 1962, et al.
(författare)
-
Colorectal Cancer Cells Adhere to Traumatized Peritoneal Tissue in Clusters, An Experimental Study.
- 2018
-
Ingår i: Journal of investigative surgery. - : Informa UK Limited. - 0894-1939 .- 1521-0553. ; 31:4, s. 349-356
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose/Aim: Colorectal malignity is one of the most common forms of cancer. The finding of free intraperitoneal colorectal cancer cells during surgery has been shown to be associated with poor outcome. The aim of this study was to develop an experimental model designed to investigate adhesion of colorectal cancer cells to the peritoneal surface.Two human experimental models were developed, the first using cultured mesothelial cells and the second consisting of an ex vivo model of peritoneal tissue. Both models were subjected to standardized trauma, following which labeled colorectal cancer cells (Colo205) were introduced. Adhesion of tumor cells was monitored using microscopy and detection of fluorochromes.The mesothelial cell layers and peritoneal membranes remained viable in culture medium for several weeks. In our experimental model, the tumor cells added were seen to adhere to the edges of the traumatized area in cluster formations.The use of human peritoneal tissue in an ex vivo model would appear to be a potentially useful tool for the study of interaction between human peritoneal membrane and free tumor cells. Experimental surgical trauma increases the ability of tumor cells to adhere to the peritoneal membrane. This ex vivo model should be useful in future studies on biological interactions between peritoneum and tumor cells in the search for novel forms of peritoneal cancer therapy.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Odelberg, Nina, et al.
(författare)
-
The Impact of a Surgical Unit's Structure and Operative Technique on Quality in Two Swedish Rural Hospitals
- 2020
-
Ingår i: Journal of investigative surgery. - : Taylor & Francis Group. - 0894-1939 .- 1521-0553. ; 33, s. 924-929
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction: Laparoscopic cholecystectomy (LC) is a commonly performed surgical procedure with a low complication rate. It is performed either as an acute or as an elective procedure. Most elective LCs are performed on nonlethal diseases and this is why good quality is important. Our study compared the quality of LC in two surgical units in northern Sweden (Sundsvall and ostersund) which use different clinical structures (subspecialised vs. general surgery) and surgical techniques (ultrasound fundus first vs. conventional diathermy). The study aimed to investigate whether these differences affected the quality of outcomes after LC.Materials and methods: This is a registry-based study which included 607 elective LCs from January 2014 to May 2016. There were 286 from Sundsvall and 321 from ostersund. Primary outcomes were operative time and the percentage of day surgeries. The secondary outcome was the presence of postoperative complications within the first 30 days in terms of bile duct injury, bleeding that necessitated reoperation, bile leakage and abscesses treated with drainage and mortality.Results: The time length of surgery was shorter in Sundsvall (mean 48.3 min) compared to ostersund (mean 108.6 min, p < 0.001. The percentage of day care surgeries was 94% in Sundsvall and 23% in ostersund, p < 0.001. Six patients (2.1%) had a complication in Sundsvall compared to seven patients (2.2%) in ostersund, p = 1.00.Conclusion: There is a significant difference between the two hospitals regarding operative time and the percentage of day surgeries. Complication rates in both units were equal and low.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Oltean, Mihai, 1976
(författare)
-
Silybin Against Liver Ischemia-Reperfusion Injury: Something Old, Something New...
- 2018
-
Ingår i: Journal of Investigative Surgery. - : Informa UK Limited. - 0894-1939 .- 1521-0553. ; 31:6, s. 521-522
-
Tidskriftsartikel (refereegranskat)abstract
- Ischemia reperfusion injury (IRI) is a life threatening condition that may develop after elective liver surgery or liver transplantation. Numerous surgical and pharmacological approaches have shown varying degrees of protection against liver IRI. A group of protective compounds are the flavonoids but their intestinal absorbtion and bioavailability are low and impredictible. In this issue Tsaroucha et al. reports significantly decreased hepatocellular injury, Fas/FasL expression and inhibited HMGB1 release in rats receiving a hydrosoluble, lyophilized complex of SLB and hydroxypropyl-beta-cyclodextrin (SLB-HP-beta-CD) intravenously.
|
|
| 9. |
- Sandblom, G
(författare)
-
Inheritance, Environment and Genesis of Inguinal Hernias
- 2022
-
Ingår i: Journal of investigative surgery : the official journal of the Academy of Surgical Research. - : Informa UK Limited. - 1521-0553. ; 35:1, s. 212-213
-
Tidskriftsartikel (refereegranskat)
|
|
| 10. |
|
|
