| 1. |
- Islam, Quamrul, 1952-, et al.
(författare)
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A new functional classification of tumor-suppressing genes and its therapeutic implications
- 2000
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Ingår i: Bioessays. - 0265-9247 .- 1521-1878. ; 22:3, s. 274-285
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Tidskriftsartikel (refereegranskat)abstract
- Cell fusion studies have demonstrated that malignancy can be suppressed by a single dose of malignancy suppressor genes (MSGs), indicating that malignancy is a recessive phenotype. Correspondingly, it is widely believed that mutational inactivation of both alleles of tumor suppressor genes (TSGs), in familial and sporadic tumors, is the formal proof of the recessive nature of malignancy. Evidence presented here, however, shows that unlike MSGs, identified solely through cell fusion studies with no gene of this class yet cloned, many well-known TSGs have gene dosage effects and inhibit cellular growth in vitro. Moreover, homozygous inactivation of a growth-inhibitory TSG (GITSG) is not directly correlated with malignancy. An alternative interpretation is provided for the loss of wild-type alleles of these genes in the tumors. It is concluded that the MSGs and the GITSGs do not belong to the same class of genes. The functional classification of tumor-suppressing genes has important implications for developing effective cancer therapies. (C) 2000 John Wiley and Sons, Inc.
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| 2. |
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| 3. |
- Ahlberg, Per E.
(författare)
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Life on Earth
- 1999
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Ingår i: Bioessays. - 0265-9247 .- 1521-1878. ; 21, s. 533-
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Tidskriftsartikel (refereegranskat)
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| 4. |
- Almén, Markus Sällman, et al.
(författare)
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Adaptive radiation of Darwin's finches revisited using whole genome sequencing
- 2016
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Ingår i: Bioessays. - : Wiley. - 0265-9247 .- 1521-1878. ; 38:1, s. 14-20
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Tidskriftsartikel (refereegranskat)abstract
- We recently used genome sequencing to study the evolutionary history of the Darwin's finches. A prominent feature of our data was that different polymorphic sites in the genome tended to indicate different genetic relationships among these closely related species. Such patterns are expected in recently diverged genomes as a result of incomplete lineage sorting. However, we uncovered conclusive evidence that these patterns have also been influenced by interspecies hybridisation, a process that has likely played an important role in the radiation of Darwin's finches. A major discovery was that segregation of two haplotypes at the ALX1 locus underlies variation in beak shape among the Darwin's finches, and that differences between the two haplotypes in a 240 kb region in blunt and pointed beaked birds involve both coding and regulatory changes. As we review herein, the evolution of such adaptive haplotypes comprising multiple causal changes appears to be an important mechanism contributing to the evolution of biodiversity.
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| 5. |
- Angeler, David
(författare)
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Biological systems - "Symphonies of Life": Reviving Friedrich Cramer's general resonance theory
- 2023
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Ingår i: BioEssays. - 0265-9247 .- 1521-1878. ; 45
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Tidskriftsartikel (refereegranskat)abstract
- Understanding biological systems in terms of scientific materialism has arguably reached a frontier, leaving fundamental questions about their complexity unanswered. In 1998, Friedrich Cramer proposed a general resonance theory as a way forward. His theory builds on the extension of the quantum physical duality of matter and wave to the macroscopic world. According to Cramer' theory, agents constituting biological systems oscillate, akin to musical soundwaves, at specific eigenfrequencies. Biological system dynamics can be described as "Symphonies of Life" emerging from the resonance (and dissonance) of eigenfrequencies within the interacting collective. His theory has potential for studying biological problems of increasing complexity in a fast-changing Anthropocene from a new and transdisciplinary angle. Despite data becoming increasingly available for analyses, Cramer's theory remains ignored and therefore untested a quarter century after its publication. This paper discusses how the theory can move to quantitative assessments and application. Cramer's general resonance theory deserves revival.Schematic of biological systems as "Symphonies of Life". Resonant and dissonant patterns are symbolized with color circle lines and shapes in gray tones, respectively. Each symbol represents an agent with specific eigenfrequencies in a biological system. Different colors symbolize distinct self-similar eigenfrequency patterns emerging from individual eigenfrequencies in the system.image
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| 6. |
- Asp, Michaela, et al.
(författare)
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Spatially Resolved Transcriptomes : Next Generation Toolsfor Tissue Exploration
- 2020
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Ingår i: Bioessays. - : Wiley. - 0265-9247 .- 1521-1878. ; 42:10, s. 1900221-
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Tidskriftsartikel (refereegranskat)abstract
- Recent advances in spatially resolved transcriptomics have greatly expandedthe knowledge of complex multicellular biological systems. The field hasquickly expanded in recent years, and several new technologies have beendeveloped that all aim to combine gene expression data with spatialinformation. The vast array of methodologies displays fundamentaldierences in their approach to obtain this information, and thus,demonstrate method-specific advantages and shortcomings. While the field ismoving forward at a rapid pace, there are still multiple challenges presentedto be addressed, including sensitivity, labor extensiveness, tissue-typedependence, and limited capacity to obtain detailed single-cell information.No single method can currently address all these key parameters. In thisreview, available spatial transcriptomics methods are described and theirapplications as well as their strengths and weaknesses are discussed. Futuredevelopments are explored and where the field is heading to is deliberatedupon.
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| 7. |
- Axelson, Håkan
(författare)
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Eyeing tumorigenesis: Notch signaling and epigenetic silencing of Rb in Drosophila.
- 2006
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Ingår i: BioEssays. - : Wiley. - 0265-9247 .- 1521-1878. ; 28:7, s. 692-695
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Tidskriftsartikel (refereegranskat)abstract
- Notch signaling plays an essential role in the processes of embryogenesis and cellular differentiation, and it is believed that the oncogenic effects of dysregulated Notch signaling are an anomalous reflection of the normal functions of this cascade. Nonetheless, the cellular events associated with oncogenic Notch signaling have thus far remained elusive. In a recent report, Ferres-Marco et al.((1)) described how they used the Drosphila eye as a model system and found that elevated Notch signaling in combination with activation of components of the Polycomb complex of transcriptional repressors led to metastatic growth of tumors through epigenetic silencing of the Rbf gene. Rbf is the Drosophila homologue of the retinoblastoma tumor-suppressor gene (Rb), thus it represents a novel link between Notch signaling, tumor growth and metastasis.
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| 10. |
- Borgstrom, F, et al.
(författare)
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Health economics of osteoporosis
- 2008
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Ingår i: Best practice & research. Clinical endocrinology & metabolism. - : Elsevier BV. - 1878-1594 .- 1521-690X. ; 22:5, s. 885-900
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Tidskriftsartikel (refereegranskat)
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