SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:1550 4131 "

Sökning: L773:1550 4131

  • Resultat 1-10 av 190
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Hällberg, B Martin, et al. (författare)
  • Making proteins in the powerhouse
  • 2014
  • Ingår i: Cell Metabolism. - Stockholm : Karolinska Institutet, Dept of Cell and Molecular Biology. - 1550-4131 .- 1932-7420.
  • Tidskriftsartikel (refereegranskat)abstract
    • Understanding regulation of mitochondrial DNA (mtDNA) expression is of considerable interest as mitochondrial dysfunction is important in human pathology and ageing. Similar to the situation in bacteria, there is no compartmentalization between transcription and translation in mitochondria; hence, both processes are likely to have a direct molecular crosstalk. Accumulating evidence suggests that there are important mechanisms for regulation of mammalian mtDNA expression at the posttranscriptional level. Regulation of mRNA maturation, mRNA stability, translational coordination, ribosomal biogenesis and translation itself, all form the basis for controlling oxidative phosphorylation capacity. Consequently, a wide variety of inherited human mitochondrial diseases are caused by mutations of nuclear genes regulating various aspects of mitochondrial translation. Furthermore, mutations of mtDNA, associated with human disease and ageing, often affect tRNA genes critical for mitochondrial translation. Recent advances in molecular understanding of mitochondrial translation regulation will likely provide novel avenues for modulating mitochondrial function to treat human disease.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  • Akerman, Ildem, et al. (författare)
  • Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks
  • 2017
  • Ingår i: Cell Metabolism. - : Elsevier BV. - 1550-4131. ; 25:2, s. 400-411
  • Tidskriftsartikel (refereegranskat)abstract
    • Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cell gene regulation and diabetes, the function of β cell lncRNAs remains largely unknown. In this study, we investigated the function of β cell-specific lncRNAs and transcription factors using transcript knockdowns and co-expression network analysis. This revealed lncRNAs that function in concert with transcription factors to regulate β cell-specific transcriptional networks. We further demonstrate that the lncRNA PLUTO affects local 3D chromatin structure and transcription of PDX1, encoding a key β cell transcription factor, and that both PLUTO and PDX1 are downregulated in islets from donors with type 2 diabetes or impaired glucose tolerance. These results implicate lncRNAs in the regulation of β cell-specific transcription factor networks.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 190
Typ av publikation
tidskriftsartikel (184)
forskningsöversikt (5)
konferensbidrag (1)
Typ av innehåll
refereegranskat (180)
övrigt vetenskapligt/konstnärligt (10)
Författare/redaktör
Zierath, JR (17)
Bäckhed, Fredrik, 19 ... (15)
Larsson, NG (13)
Berggren, PO (9)
Renström, Erik (9)
Cannon, Barbara (8)
visa fler...
Nedergaard, Jan (8)
Groop, Leif (7)
Kroemer, G (6)
Enerbäck, Sven, 1958 (6)
Salehi, S Albert (5)
Nielsen, Jens B, 196 ... (5)
Krook, A (5)
Ryden, M (5)
Mardinoglu, Adil, 19 ... (5)
Barres, R (5)
Marschall, Hanns-Ulr ... (4)
Tremaroli, Valentina ... (4)
Caicedo, A (4)
Arner, P (4)
Borén, Jan, 1963 (4)
Gao, H. (4)
Trifunovic, A (4)
Wibom, R (4)
Eliasson, Lena (4)
Krus, Ulrika (4)
Larsson, Nils-Göran (4)
Smith, Ulf, 1943 (4)
Larsson, O (3)
Madeo, F (3)
Lyssenko, Valeriya (3)
Abdulreda, MH (3)
Ricordi, C (3)
Rodriguez-Diaz, R (3)
Angelin, B (3)
Rorsman, Patrik, 195 ... (3)
Mulder, Hindrik (3)
Blom, Anna (3)
Taneera, Jalal (3)
Rosengren, Anders (3)
Vikman, Petter (3)
Wahlström, Annika, 1 ... (3)
Ståhlman, Marcus, 19 ... (3)
Rudling, M (3)
Laakso, M. (3)
Cao, Yihai (3)
Clement, K (3)
Perkins, Rosie, 1965 (3)
Dahlman, I (3)
Mejhert, N (3)
visa färre...
Lärosäte
Karolinska Institutet (105)
Göteborgs universitet (43)
Lunds universitet (24)
Uppsala universitet (16)
Stockholms universitet (12)
Kungliga Tekniska Högskolan (8)
visa fler...
Chalmers tekniska högskola (8)
Umeå universitet (7)
Linköpings universitet (4)
Sveriges Lantbruksuniversitet (4)
Örebro universitet (2)
Gymnastik- och idrottshögskolan (2)
visa färre...
Språk
Engelska (190)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (83)
Naturvetenskap (29)
Lantbruksvetenskap (3)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy