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- Comley, Robert A., et al.
(författare)
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A Comparison of Gray Matter Density in Restless Legs Syndrome Patients and Matched Controls Using Voxel-Based Morphometry
- 2012
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Ingår i: Journal of Neuroimaging. - : WILEY-BLACKWELL. - 1051-2284 .- 1552-6569. ; 22:1, s. 28-32
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Restless legs syndrome (RLS) is a common neurological disorder the pathophysiology of which is incompletely understood. Four studies have examined structural differences between the brains of RLS patients and healthy controls, using voxel-based morphometry (VBM). All 4 studies have provided different results. METHODS Optimized VBM was used to search for structural differences in gray matter density. Sixteen RLS patients naive to dopaminergic drugs and 16 age-and sex-matched controls received structural T1-weighted MR scans. Structural data were analyzed using FSL-VBM. RESULTS No difference in gray matter density was detected between the two groups (voxel-wise significance: no significant voxels at P = .89 (whole brain Family Wise Error (FWE) corrected); no significant voxels at P < .05 (whole brain False Discovery Rate (FDR) corrected; smallest achievable FDR threshold .99). CONCLUSION/DISCUSSION The present study did not replicate (confirm) previous findings of structural brain changes in RLS, but instead supported the findings of a recent study showing a lack of gray matter alteration in an elderly RLS population. More specifically, the results do not support neuronal loss as an underlying disease mechanism in RLS. Potential limitations in the application of VBM are also discussed.
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| 3. |
- Liu, Xiang, et al.
(författare)
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A case of cervical spinal cord glioblastoma diagnosed with MR diffusion tensor and perfusion imaging.
- 2011
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Ingår i: Journal of neuroimaging : official journal of the American Society of Neuroimaging. - : Wiley. - 1552-6569. ; 21:3, s. 292-6
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Tidskriftsartikel (refereegranskat)abstract
- Intramedullary glioblastomas in adult patients have rarely been reported. We describe magnetic resonance (MR) imaging findings, include findings on diffusion tensor imaging (DTI) and dynamic susceptibility contrast perfusion weighted imaging (PWI) in a case of autopsy-confirmed glioblastoma in a 72-year-old man. Serial MR examinations, DTI and PWI, and positron emission tomography examinations were performed. The tumor involved the medulla oblongata and the upper cervical spinal cord. Traditional MR imaging findings were unclear with regard to the differential diagnosis between intramedullary glioma or a tumefactive demyelinating lesion, but an increase in regional cerebral blood volume and a decrease in fractional anisotropy of the lesion correctly suggested a high-grade glioma. MR PWI and DTI may prove helpful to diagnose glioblastoma of the cervical cord when other imaging features are inconclusive.
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| 7. |
- Fällmar, David, et al.
(författare)
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Visual Assessment of Brain Perfusion MRI Scans in Dementia : a Pilot Study
- 2016
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Ingår i: Journal of Neuroimaging. - : Wiley. - 1051-2284 .- 1552-6569. ; 26:3, s. 324-330
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Functional imaging is becoming increasingly important for the detection of neurodegenerative disorders. Perfusion MRI with arterial spin labeling (ASL) has been reported to provide promising diagnostic possibilities but is not yet widely used in routine clinical work. The aim of this study was to compare, in a clinical setting, the visual assessment of subtracted ASL CBF maps with and without additional smoothing, to FDG-PET data.METHODS: Ten patients with a clinical diagnosis of dementia and 11 age-matched cognitively healthy controls were examined with pseudo-continuous ASL (pCASL) and 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET). Three diagnostic physicians visually assessed the pCASL maps after subtraction only, and after postprocessing using Gaussian smoothing and GLM-based beta estimate functions. The assessment scores were compared to FDG PET values. Furthermore, the ability to discriminate patients from healthy elderly controls was assessed.RESULTS: Smoothing improved the correlation between visually assessed regional ASL perfusion scores and the FDG PET SUV-r values from the corresponding regions. However, subtracted pCASL maps discriminated patients from healthy controls better than smoothed maps. Smoothing increased the number of false-positive patient identifications. Application of beta estimate functions had only a marginal effect.CONCLUSION: Spatial smoothing of ASL images increased false positive results in the discrimination of hypoperfusion conditions from healthy elderly. It also decreased interreader agreement. However, regional characterization and subjective perception of image quality was improved.
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| 9. |
- Haller, Sven, et al.
(författare)
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MRI of nigrosome-1 : A potential triage tool for patients with suspected parkinsonism
- 2022
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Ingår i: Journal of Neuroimaging. - : John Wiley & Sons. - 1051-2284 .- 1552-6569. ; 32:2, s. 273-278
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Tidskriftsartikel (refereegranskat)abstract
- Background and Purpose Susceptibility-weighted imaging (SWI) of nigrosome-1 is an emerging and clinically applicable imaging marker for parkinsonism, which can be derived from routinely performed brain MRI. The purpose of the study was to assess whether SWI can be used as a triage tool for more efficient selection of subsequent Dopamine Transporter Scan (DaTSCAN) single-photon emission computed tomography (SPECT). Methods We examined 72 consecutive patients with suspected parkinsonism with both DaTSCAN SPECT and SWI (48 in Philips Ingenia, 24 in GE Signa). Additionally, we examined 24 healthy controls with SWI (14 in Philips Ingenia, 10 in GE Signa). Diagnostic performance of SWI and DaTSCAN SPECT was assessed on the basis of clinical diagnosis, in terms of sensitivity, specificity, and diagnostic accuracy. Results A total of 54 parkinsonism patients (69 years +/- 9, 32 men), 18 nonparkinsonism patients (69.4 years +/- 9, 10 men), and 24 healthy controls (62 years +/- 8, 10 men) were recruited. SWI had a specificity of 92% and a sensitivity of 74%, whereas DaTSCAN SPECT had 83% and 94%, respectively. By preselecting patients with abnormal or inconclusive SWI, the diagnostic performance of DaTSCAN SPECT improved (specificity 100%, sensitivity 95%). Scans from Philips were associated with significantly lower image quality compared to GE (p < .001). The experienced rater outperformed the less experienced one in diagnostic accuracy (82% vs. 68%). Conclusions SWI can be used as triage tool because normal SWI can in most cases rule out parkinsonism. However, the performance of SWI depends on acquisition parameters and rater's experience.
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