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| 2. |
- Ayadi, A, et al.
(författare)
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The European Mouse Mutant Archive (EMMA)
- 2011
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Ingår i: JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE. - 1559-6109. ; 50:5, s. 786-787
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Hedenqvist, Patricia
(författare)
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Toward Global Harmonization of Training and Certification of Specialists in Laboratory Animal Veterinary Medicine
- 2022
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Ingår i: Journal of the American Association for Laboratory Animal Science. - 1559-6109. ; 61, s. 15-20
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Forskningsöversikt (refereegranskat)abstract
- Laboratory animal medicine (LAM) is a corner stone of animal-based research and has been a veterinary specialty for over 60 y. Today 5 Colleges of LAM (American, European, Japanese, Korean, and Indian) that certify specialists (Diplomates) in LAM are members of the International Association of Colleges of LAM (IACLAM). Goals of IACLAM are to support the development of new Colleges of LAM, to harmonize expectations for the knowledge and skills of newly certified LAM Diplomate, and to harmonize the standards (best practices) for training and examination of candidates among the member Colleges. IACLAM recently conducted an in-depth review and comparison of oversight, training, credentialing, and examination standards in the 5 Colleges as part of an initiative to create a framework for harmonization and consistency for these activities across the 5 Colleges. The process has led to an agreement on recommendations for knowledge and skill requirements for a newly certified Diplomate, as described by each College in a detailed role delineation document (RDD). The RDD is based on task analyses of the work responsibilities of laboratory animal veterinary Diplomates. This agreement is an important step toward the goal of global harmonization of LAM Diplomate training. Further efforts are planned for areas such as training, research, publication, and examination. This paper describes the role and content of the RDD and lists the differences and similarities among the RDDs of 5 Colleges of LAM.
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| 6. |
- Spangenberg, Elin, et al.
(författare)
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Assessment of laboratory mouse Welfare using animal-based measures
- 2013
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Ingår i: Journal of the American Association for Laboratory Animal Science. - 1559-6109. ; 52, s. 348-348
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Protocols to assess laboratory animal health and welfare are commonly used in experimental studies to record the outcome on the animal as a result of an experimental input. In laboratory mice, many of the welfare problems do however occur in the home cage and are irrespective of the type of research. Assessment of the home cage environment is commonly performed using resource-based measures for example, group size or access to nesting material. Since animals react differently to the same environment depending on age, sex, genetic background, previous experiences etc., it is more relevant to assess welfare as animalbased (outcome) measures rather than resource and management-based (input) measures. The same animal-based measures can then be applied in different types of animal facilities, allowing comparisons between them, or to track changes over time following modification in housing and management within the same facility. The aim of this project was to design and test a protocol for assessing the welfare of laboratory mice in their home cage using only animal-based measures. The parameters used were selected to cover different aspects of animal welfare, namely good feeding, housing and health, and appropriate behavior. These aspects are divided into 12 welfare criteria and parameters were selected to match the criteria, to be feasible in practise and, if possible, be already validated indicators of mouse welfare. The protocol was tested at three different animal facilities in Sweden during 2012. The development of the protocol and results from the testing will be presented
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| 7. |
- Spangenberg, Elin, et al.
(författare)
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Methods for Investigating the Motivation of Mice to Explore and Access Food Rewards
- 2018
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Ingår i: Journal of the American Association for Laboratory Animal Science. - 1559-6109. ; 57, s. 244-252
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Tidskriftsartikel (refereegranskat)abstract
- The emotional state of domestic animals is an essential component of the assessment of their welfare. In addition, sensitivity to various rewards can be a valuable indicator when investigating these states. We aimed to design an exploration test and a contrast test that did not evoke fear and anxiety in C57BL/6N mice but that instead were perceived as positive experiences and that might be used to assess sensitivity to various rewards. The exploratory arena had a larger central area and 8 smaller sections containing various objects. Motivation (measured as latency to enter the arena under conditions of increasing weight of the entrance door), anticipation (measured as latency to enter the arena under conditions of increasing delay in opening the entrance door), and the numbers of visits to the different sections were evaluated during a 5-min session in the arena. In the contrast test, after traversing a runway, half of the mice received a tasty reward (hazelnut cream), whereas the others received a neutral reward (food pellet) at the far end. Latency to reach the reward was recorded. After baseline training, rewards were swapped for half of the mice from each category for 3 d, to establish a negative and positive contrast. Mice were both motivated and showed anticipation to enter the exploration arena; after entering, they were active and visited many sections. In the contrast test, latency during the baseline period was longer for mice given the neutral reward compared with the tasty reward. Compared with baseline, latency during the postshift phase decreased for the positive-contrast group (neutral-tasty reward pattern) but did not differ for the negative-contrast group (tasty-neutral reward pattern). Overall, both tests seemed to be positive experiences for the mice and showed potential for use to investigate reward sensitivity.
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